Soluble A-SH CoA-SH Q10 composition and its production

A water-soluble, composition technology, applied in the directions of drug combination, pharmaceutical formula, allergic diseases, etc., can solve the problems of not involving preparation technology, undisclosed use of high-pressure homogenization preparation method, unsuitable for industrial production, etc. Water solubility, improved stability, fast dissolution effect

Active Publication Date: 2007-06-20
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES +1
View PDF2 Cites 22 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are a large number of patents in the published literature, among which coenzyme Q in recent years 10 There are many utility patents, and there are following patents and documents related to this patent after retrieval: 1. in the document Journal Acta Poloniae Pharmaceutica (1995), vol.52, No.5, pp.379-386 and 1996, vol.53, No. 3, pp.193-196. described the preparation of coenzyme Q by stirring method 10 γ-cyclodextrin inclusion compound, but this method requires more than tens of hours to prepare, and is not suitable for industrial production
② U.S. Patent 6861447, which discloses a method for preparing gamma-cyclodextrin inclusion compounds, but the preparation of drugs by this method has the above-mentioned shortcomings. In addition, this method does not disclose the preparation method of using high-pressure homogenization
③The world patent WO20041080208, which uses emulsification technology, discloses a formula and process for preparing an oral milk powder and organic acid, and does not involve water-soluble coenzyme Q 10 Preparation technology
④ Chinese patent CN1437931 discloses a coenzyme Q 10 Preparation technology of proliposome, not related to this technology

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Soluble A-SH CoA-SH Q10 composition and its production
  • Soluble A-SH CoA-SH Q10 composition and its production
  • Soluble A-SH CoA-SH Q10 composition and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Water-soluble coenzyme Q of the present invention 10 The composition consists of the following raw materials in weight ratio: Coenzyme Q 10 : gamma cyclodextrin: mannitol: sodium carboxymethyl starch = 1: 1: 1: 0.1;

[0045] According to the above weight ratio, take 10g of γ-cyclodextrin and 10g of mannitol, dissolve them in 2000ml of water, heat to 60°C, put them into a high-speed homogenizer or shearing machine, and add coenzyme Q that meets the above weight ratio 10 10g, stir at 5000-10000 rpm for 5-10 minutes at high speed, discharge the material into a high-pressure homogenizer, cycle 10 times at 40Mpa, discharge the material, filter with a microporous membrane, add sodium carboxymethyl starch to the filtrate to dissolve, and then carry out Spray-dried and granulated to obtain the finished product.

Embodiment 2

[0047] Water-soluble coenzyme Q of the present invention 10 The composition consists of the following raw materials in weight ratio: Coenzyme Q 10 : gamma cyclodextrin: mannitol: sodium carboxymethyl starch = 1: 100: 50: 5;

[0048] According to the above weight ratio, take 100g of γ-cyclodextrin, dissolve it in 1000ml of water, heat it to 50°C, put it into a high-speed homogenizer or a shearing machine, and add coenzyme Q that meets the above weight ratio 10 1g and 50g of mannitol, stir at 5000-10000 rpm for 5-10 minutes at high speed, feed into a high-pressure homogenizer, circulate once at 100Mpa, discharge, filter with a microporous membrane, add sodium carboxymethyl starch to the filtrate 5g was dissolved, then spray-dried and granulated to obtain the product.

Embodiment 3

[0050] Water-soluble coenzyme Q of the present invention 10 The composition consists of the following raw materials in weight ratio: Coenzyme Q 10 : gamma cyclodextrin: mannitol: crospovidone = 1: 8: 3: 0.2;

[0051] According to the above weight ratio, take 80g of γ-cyclodextrin and 30g of mannitol, dissolve them in 4000ml of water, heat to 80°C, put them into a high-speed homogenizer or shearing machine, and add coenzyme Q that meets the above weight ratio 10 10g, stir at high speed at 5000-10000 rpm for 5-10 minutes, discharge the material into a high-pressure homogenizer, circulate 5 times at 80Mpa, discharge the material, filter with a microporous membrane, add 2g of crospovidone to the filtrate to dissolve, and then It is freeze-dried and granulated to obtain the finished product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A water-soluble coenzyme Q10 composition for treating cardiovascular disease, hepatitis and hypoimmunocompetence is proportionally prepared from coenzyme Q10, gamma-cyclodextrin, alditol and disintegrant through high-speed stirring in water or ultrasonic oscillating, high-pressure homogenizing, freeze-drying, and granulating.

Description

technical field [0001] The invention relates to a water-soluble coenzyme Q 10 The composition and preparation method, the substance has good therapeutic effects on diseases such as cardiovascular diseases, hepatitis, and low immunity, and belongs to the technical field of medicines and health care products. Background technique [0002] coenzyme Q 10 Also known as ubiquinone, also known as decenoquinone, ubiquinone alcohol, vitamin Q, vitamin coenzyme Q, the English name is Coenzyme Q 10 , Ubiquinone, the molecular formula is C 59 h 90 o 4 , the chemical formula is 2-(3,7,11,15,19,23,27,31,35,39-decylmethyl-2,6,10,14,18,22,26,30,34,38- Fortydecenyl)-5,6-dimethoxy-3-methyl-p-benzoquinone, this substance is an autologous substance of the human body, and also widely exists in the heart of animals and other organs, and can be extracted from the heart of animals. It can also be obtained through chemical synthesis and biosynthesis. coenzyme Q 10 It is an indispensable and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P9/00A61P1/16A61P37/04
Inventor 董英杰艾莉
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap