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Albendazol dispersible tablets and preparation method thereof

A kind of technology of albendazole and dispersible tablets, applied in the field of albendazole dispersible tablets and preparation thereof, and can solve the problems such as not finding albendazole

Inactive Publication Date: 2012-12-05
宁夏启元国药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the prior art, it has not been found that there is a technology for making albendazole into dispersible tablets

Method used

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  • Albendazol dispersible tablets and preparation method thereof
  • Albendazol dispersible tablets and preparation method thereof
  • Albendazol dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1: The dispersible tablets include the following raw materials in weight ratio per 1000 tablets: 200g of albendazole, 16g of polyvinylpolypyrrolidone, 80g of low-substituted hydroxypropyl cellulose, 60g of microcrystalline cellulose, and 8g of lactose , sodium lauryl sulfate 8g, stevia 12g, micronized silica gel 12g, magnesium stearate 4g;

[0075] Above-mentioned albendazole dispersible tablet, its preparation process is:

[0076] a. Material preparation: Weigh the prescribed amount of albendazole, microcrystalline cellulose, crospovidone, low-substituted hydroxypropyl cellulose, lactose and other materials, grind them, pass through a 100-mesh sieve, and put them in a clean container , sealed and preserved.

[0077] b. Take the sodium lauryl sulfate and stevioside of the prescribed amount, dissolve them in 14 times the amount of water, and use them as wetting agents for later use.

[0078] C, granulation: take albendazole fine powder, mix with the crospovidon...

Embodiment 2

[0082] Embodiment 2: every 1000 tablets of this dispersible tablet include the raw materials of following weight ratio: albendazole 200g, crospovidone 80g, croscarmellose sodium 20g, microcrystalline cellulose 60g, lactose 8g, sodium lauryl sulfate 8g, stevia 12g, micronized silica gel 8g, magnesium stearate 4g;

[0083] The preparation technology of above-mentioned albendazole dispersible tablet is identical with embodiment 1.

Embodiment 3

[0084] Embodiment 3: every 1000 tablets of this dispersible tablet include the raw materials of the following weight ratio: 200g of albendazole, 60g of crospovidone, 24g of low-substituted hydroxypropyl cellulose, croscarmellose sodium 20g, microcrystalline cellulose 50g, lactose 10g, sodium lauryl sulfate 12g, stevia 16g, micropowder silica gel 4g, magnesium stearate 4g;

[0085] The preparation technology of above-mentioned albendazole dispersible tablet is identical with embodiment 1.

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Abstract

The invention relates to albendazol dispersible tablets and a preparation method thereof. The albendazol dispersible tablets comprise, by weight ratio, 200g of albendazol, 50-160g of disintegrant, 18-118g of diluent, 2-12g of surfactant, 6-16g of sweetener, 3-12g of glidant, and 1-4g of lubricant. Bioavailability of the albendazol dispersible tablets made from the proper accessories is improved evidently, and curative effect of the albendazol dispersible tablets is improved. The albendazol dispersible tablets are available to take in multiple ways, and different patients can take the albendazol dispersible tablets in different ways, so that patient compliance is improved. Practice shows that preparation technology of the albendazol dispersible tablets is high in production mechanization level, simple to operate, high in production efficiency and low in cost. The dispersible tablets produced by the preparation technology have the advantages of high dispersing uniformity, short disintegrating time, and fast dissolution, and the product quality completely meets the requirements.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy, in particular to an albendazole dispersible tablet and a preparation method thereof. Background technique [0002] A parasite is an organism that spends most of its life living on another animal (called a host or host) and at the same time causing damage to the parasited animal. Diseases caused by parasites are called "parasitic diseases" in medicine. It is characterized by all organisms that parasitize in the host or host (host) or attach to the outside to obtain the nutrients or shelter needed to maintain their survival, development or reproduction. Ascariasis is a disease caused by roundworms that live in the human intestine. Roundworm eggs contaminate soil, water, or food, and people become sick if they eat the contaminated food. Children like to play with dirt. If they get roundworm eggs on their hands and don't wash their hands before meals, they are prone to ascariasis. Most ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4184A61K47/38A61P33/10
Inventor 丁建宝李琳
Owner 宁夏启元国药有限公司
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