Water-soluble coenzyme Q10 combination and preparation method thereof

A composition and water-soluble technology, which is applied in the field of medicine, can solve the problems of insufficient content of coenzyme Q10 active substances, low stability of inclusion compound suspension or precipitation, etc., and achieve the effect of low cost, easy acquisition and high stability

Inactive Publication Date: 2011-01-12
杭州华东医药集团康润制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effective substance content of coenzyme Q10 produced by this method is not high enough, and the clathrate prepared by cyclodextrin is prone to suspension or precipitation, resulting in low stability

Method used

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  • Water-soluble coenzyme Q10 combination and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepared by dissolving coenzyme Q10 in an organic solvent and then mixing it with an emulsifier:

[0036] Take 10g of coenzyme Q10 and 20g of polyoxyethylene-40-stearate, dissolve in 100ml of absolute ethanol, stir to form a clear and transparent solution as a spare solution; take 1000ml of 50°C hot water, add 65g of water-soluble starch and 5g of CMC, While stirring and dissolving to clarify the solution, add the reserve solution at a dropping rate of 0.35 ml / s, cut it with a shear disperser at a speed of 3000 rpm for 60 minutes, take it out, and spray it under the drying parameters of 170°C for air inlet and 90°C for air outlet Dry, collect the spray powder and sieve to obtain the finished product.

[0037] The following is the performance test of the obtained water-soluble coenzyme Q10 composition: the method for determining the content of the water-soluble coenzyme Q10 composition mainly adopts high-performance liquid chromatography. About 1mg / ml), filter, take the...

Embodiment 2

[0055] Prepared by direct heating and melting of coenzyme Q10 and emulsifier:

[0056] Take 10g of coenzyme Q10, 80g of pure gum, 30g of sucrose fatty acid ester and 0.5g of vitamin E, dissolve them in 200ml of water, heat to 60°C to melt, then use a shearing disperser to cut at 2000rpm for 50min, take it out, and put it in the air Spray drying under the drying parameters of 170°C and air outlet of 90°C, collect the spray powder and sieve to obtain the finished product.

[0057] The performance testing method of the obtained water-soluble coenzyme Q10 composition is the same as that in Example 1.

[0058] 1. Stability test

[0059] The maximum absorption wavelength of coenzyme Q10 is 275±1nm, and the maximum absorption wavelength of reduced coenzyme Q10 is 291±1 nm. The detection value of the water-soluble coenzyme Q10 composition in this experiment is 4% under the chromatographic conditions (C18 column, mobile phase: methanol: absolute ethanol = 1:1, detection wavelength 29...

Embodiment 3

[0075] Prepared by dissolving coenzyme Q10 in an organic solvent and then mixing it with an emulsifier:

[0076] Take 15g of coenzyme Q10, 20g of sorbitol fatty acid ester and 20g of poloxamer, dissolve it in 150ml of ethyl acetate, stir it into a clear and transparent solution as a spare solution; take 3000ml of 40°C hot water, add 60g of lactose and 40g of gum arabic , while stirring and dissolving to clarify the solution, add the reserve liquid at a dropping rate of 0.5 ml / s, cut it with a shear disperser at a speed of 4000 rpm for 80 minutes, and take it out. Spray drying, collecting the spray powder and sieving to obtain the finished product.

[0077] The performance test method of the obtained water-soluble coenzyme Q10 composition is the same as in Example 1, and the results are shown in Table 1, Table 2 and Table 3.

[0078] Table 1 shows that light has a greater impact on coenzyme Q10. The water-soluble coenzyme Q10 composition in Example 3 of the present invention ...

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Abstract

The invention relates to a coenzyme Q10 combination and a preparation method thereof and provides a water-soluble coenzyme Q10 combination, which contains the following raw materials in parts by weight: 5-15 parts of coenzyme Q10, 10-120 parts of water-soluble carrier and 0.5-40 parts of emulsifier; the water-soluble carrier is one or more of maltodextrin, CMC, purity gum, soluble starch, lactose, fructose, sorbierite, mannite, Arabic gum, carrageenan, microcrystalline cellulose and sodium carboxymethyl starch; and the emulsifier is non-ionic surfactant. The invention also provides the preparation method of the water-soluble coenzyme Q10 combination. Fat-soluble coenzyme Q10, the water-soluble carrier and the amphoteric emulsifier are mixed and prepared into the water-soluble coenzyme Q10 combination, and the method synthesizes the advantages of an inclusion technique and a solid dispersion technique and solves the problems that the fat-soluble coenzyme Q10 is difficult to dissolve in water and has low bioavailability, and a number of experiments prove that the water-soluble coenzyme Q10 combination has good water solubility, fast dissolution rate, good stability and high content of effective substances.

Description

[0001] technical field [0002] The invention relates to the technical field of medicine, in particular to a coenzyme Q10 composition and a preparation method thereof. Background technique [0003] Coenzyme Q is an essential component widely distributed in organisms ranging from bacteria to mammals. The basic structure of coenzyme Q is 2, 3-dimethoxy-5-methylbenzoquinone nucleus containing isoprenoid side chains. Coenzyme Q in the human body contains ten such basic structures, namely coenzyme Q10, It was first isolated from bovine myocardium by Frederrick in 1957. It is known that in the human body, the side chain of coenzyme Q has 10 repeating structures, that is, coenzyme Q10 is the main component. Coenzyme Q10 (molecular formula C 59 h 90 o 4 ) is a physiological component that exists as a constituent component of the electron transport system of the mitochondria in the cells of a living body, and is repeatedly oxidized and reduced in the living body to function as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61K47/40A61K47/38A61K47/36A61K47/26A61K47/10A61P9/04A61K31/355
Inventor 蒋风王维周建仁毛海明
Owner 杭州华东医药集团康润制药有限公司
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