Water soluble coenzyme Q10 hydroxyl-beta-cyclodextrin inclusion compound and its preparation method

A technology of cyclodextrin inclusion compound and hydroxypropyl group, which is applied in the field of medicine and health care products, and can solve the problems of easy precipitation of β-cyclodextrin inclusion compound solution, inability to be used for injection, and high price of γ-cyclodextrin , to achieve good water solubility, high bioavailability, and fast dissolution

Active Publication Date: 2007-10-17
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high price of γ-cyclodextrin, the application is limited
Although β-cyclodextrin is cheap, its β-cyclodextrin inclusion complex solution is easy to precipitate, which limits its application in liquid preparations such as beverages
Use γ-cyclodextrin and β-cyclodextrin for inclusion, neither can be used for injection administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Water-soluble coenzyme Q of the present invention 10 The hydroxypropyl-β-cyclodextrin inclusion compound is composed of the following raw materials in weight ratio, coenzyme Q 10 : Hydroxypropyl-β-cyclodextrin = 1:1;

[0029] According to the above weight ratio, take 10g of hydroxypropyl-β-cyclodextrin, dissolve it in 200g of water, heat it to 60°C, put it into a high-speed homogenizer or shearing machine, and mix the coenzyme Q that meets the above weight ratio 10 10g is heated and dissolved with 20g ethanol, then added to the cyclodextrin solution, stirred and sheared at a high speed at 5000-10000 rpm for 20 minutes, fed into a high-pressure homogenizer, circulated 10 times at 40Mpa, discharged, with 10μm micropore Membrane filtration, and then spray drying, that is.

Embodiment 2

[0031] Water-soluble coenzyme Q of the present invention 10 The hydroxypropyl-β-cyclodextrin inclusion complex is composed of the following raw materials in weight ratio: Coenzyme Q 10 : Hydroxypropyl-β-cyclodextrin = 1:100;

[0032] According to the above weight ratio, take 100g of hydroxypropyl-β-cyclodextrin, dissolve it in 1000g of water, heat it to 50°C, put it into a high-speed homogenizer or a shearing machine, and add coenzyme Q that meets the above weight ratio 10 1g, high-speed stirring at 5000-10000 rpm for 5 minutes, feeding into a high-pressure homogenizer, circulating once at 100Mpa, discharging, filtering with a 3μm microporous membrane, and then freeze-drying to obtain.

Embodiment 3

[0034] Water-soluble coenzyme Q of the present invention 10 The hydroxypropyl-β-cyclodextrin inclusion complex is composed of the following raw materials in weight ratio: Coenzyme Q 10 : Hydroxypropyl-β-cyclodextrin = 1:50;

[0035] According to the above weight ratio, take 50g of hydroxypropyl-β-cyclodextrin, dissolve it in 1000g of water, heat it to 80°C, put it into a high-speed homogenizer or shearing machine, and add coenzyme Q that meets the above weight ratio 10 1g, high-speed stirring at 5000-10000 rpm for 10 minutes, feeding into a high-pressure homogenizer, circulating 5 times at 80Mpa, discharging, filtering with a 5μm microporous membrane, and then freeze-drying to obtain.

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PUM

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Abstract

The invention relates to a water-solubility coenzyme Q10 hydroxypropyl-beta-cyclodextrin clathrate and its producing method belonging to medicine and health product field, which has a good treatment effect to the cardiovascular diseases, hepatitis, weak immunity. It contains following material with a weight ratio of coenzyme Q10: hydroxypropyl-beta-cyclodextrin=1:0.5-100 and containing the producing steps of: blending in the water medium by high-speed scattering machine or shears, then in a high pressure homogeneous machine, finally spary drying or freeze-out to prepare the coenzyme Q10 clathrate. The clathrate can be produced to the oral liquid and injection type, which has a high solubility and dissolution, a small wettability, a good stability, and a high relative bioavailability.

Description

technical field [0001] The invention relates to a water-soluble coenzyme Q 10 The composition and preparation method, the substance has good therapeutic effects on diseases such as cardiovascular diseases, hepatitis, and low immunity, and belongs to the technical field of medicines and health care products. Background technique [0002] coenzyme Q 10 Also known as ubiquinone, also known as decenoquinone, ubiquinone alcohol, vitamin Q, vitamin coenzyme Q, the English name is Coenzyme Q 10 , Ubiquinone, molecular formula C 59 h 90 o 4 , the chemical formula is 2-(3,7,11,15,19,23,27,31,35,39-decylmethyl-2,6,10,14,18,22,26,30,34,38- Fortydecenyl)-5,6-dimethoxy-3-methyl-p-benzoquinone, this substance is an autologous substance of the human body, and also widely exists in the heart of animals and other organs, and can be extracted from the heart of animals. It can also be obtained through chemical synthesis and biosynthesis. coenzyme Q 10 It is an indispensable and importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K47/40A61K9/19A61K9/20A61K9/48A61K9/08A61P9/00A61P1/16A61P31/12
Inventor 董英杰艾莉邹小峰
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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