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Azilsartan tablet and preparation method thereof

An azilsartan tablet and tablet technology, applied in the field of medicine, achieves the effects of good stability, simple process, and fast dissolution rate

Active Publication Date: 2014-07-23
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The above patents only conduct research on how to improve the dissolution rate, and do not fundamentally solve the problem of the increase of related substances

Method used

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  • Azilsartan tablet and preparation method thereof
  • Azilsartan tablet and preparation method thereof
  • Azilsartan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation Process:

[0029] (1) Azilsartan is micronized, D90 is controlled to be less than 20 microns, and the prescribed amount is weighed;

[0030] (2) Anhydrous lactose 21AN was passed through a 65-mesh sieve, and the particles were removed by sieving, and the recipe quantity was weighed;

[0031] (3) Mix (1) and (2) evenly, add lactose anhydrous 24AN, magnesium stearate, and crospovidone in the recipe quantity, mix well, and press into tablets.

Embodiment 2

[0033]

[0034]

[0035] Preparation Process:

[0036] (1) Azilsartan is micronized, D90 is controlled to be less than 20 microns, and the prescribed amount is weighed;

[0037] (2) Anhydrous lactose 21AN was passed through a 65-mesh sieve, and the particles were removed by sieving, and the recipe quantity was weighed;

[0038] (3) Mix (1) and (2) evenly, add anhydrous lactose 24AN, magnesium stearate, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, silicon dioxide of the recipe quantity and mix well, press into tablets .

Embodiment 3

[0040]

[0041] Preparation Process:

[0042] (1) Azilsartan is micronized, D90 is controlled to be less than 20 microns, and the prescribed amount is weighed;

[0043] (2) Anhydrous lactose 21AN was passed through a 65-mesh sieve, and the particles were removed by sieving, and the recipe quantity was weighed;

[0044] (3) Mix (1) and (2) evenly, add lactose anhydrous 24AN, magnesium stearate, and crospovidone in the recipe quantity, mix well, and press into tablets.

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Abstract

The invention relates to an Azilsartan tablet and a preparation method thereof. The Azilsartan tablet contains micronized Azilsartan, lactose anhydrous 21AN, lactose anhydrous 24AN, a disintegrating agent, and a lubricant, and is prepared by pressing through adopting tabletting technology. Compared with the prior art, the Azilsartan tablet is fast in dissolving speed, simple in technology, and an acceleration test result shows that the prepared Azilsartan tablet has good stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an azilsartan tablet and a preparation method thereof. Background technique [0002] Azilsartan is an angiotensin II receptor antagonist drug for the treatment of hypertension. It is mostly used for the treatment of hypertension. It is also the only angiotensin II receptor antagonist (sartan) drug in the terminal clinical stage. . The drug was launched by Japan's Takeda Pharmaceutical Company in 2012, and its clinical efficacy is remarkable. [0003] Azilsartan is a poorly soluble drug with a solubility in water of less than 9 μg / ml. The structure is as follows: [0004] [0005] The bioavailability of a drug in the body is greatly affected by the dissolution of the drug. Azilsartan is almost insoluble in water and is a poorly soluble drug. When making pharmaceutical preparations, micronized azilsartan particles are often used, and the particle size is control...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4245A61K47/26A61P9/12
Inventor 赵志全郝贵周徐志杰陈美丽
Owner SHANDONG NEWTIME PHARMA
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