A method for constructing a bionic intestinal model based on microfluidic technology

A construction method and technology of biomimetic intestines, applied in biochemical equipment and methods, artificial cell constructs, biochemical instruments, etc., to achieve the effects of promoting cell growth, improving cell function, and increasing residence time
CN107955787BActive Publication Date: 2021-10-15DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2021-10-15

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Abstract

A method for constructing a bionic intestinal model based on microfluidic technology, which is applied to the construction of an in vitro intestinal model. The microfluidic chip prepared by this preparation method is mainly composed of an upper chip, a porous filter membrane, and a lower chip. A peristaltic flow is formed in the body, and this peristaltic flow is used to simulate the actual fluid situation in the intestinal tract in the body, which has a better effect on promoting intestinal function. It is of great significance for the realization of intestinal chip in vitro simulation environment and the application of drug evaluation.
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Description

technical field

[0001] The invention relates to a construction method of a bionic intestinal model, in particular to a construction method of a bionic intestinal model based on microfluidic technology. Background technique

[0002] Animal experiments occupy an extremely important position in modern medicine and biology, but funding and animal ethics have also become unavoidable issues. Combining microfluidic technology and bioscience technology, an "organ chip" has been created, which can replicate the functions of human organs with microchips, making medical experiments easier.

[0003] Oral administration, as a traditional way of administration, is widely accepted by people because of its relative convenience and safety. The absorption process is one of the key factors determining the bioavailability of orally administered drugs. The small intestine is the main site of oral drug absorption, so at present, various in vitro and in vivo intestinal absorption models are main...

Claims

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