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Ferulic acid drug composition and new application thereof

The technology of a composition and ferulic acid, which is applied in the field of pharmacy, can solve the problems of lack of drugs for the prevention and treatment of radioactive intestinal damage

Inactive Publication Date: 2018-10-30
NAT INST FOR RADIOLOGICAL PROTECTION & NUCLEAR SAFETY CHINESE CENT FOR DISEASE CONTROL & PREVENTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of effective drugs for the prevention and treatment of radiation-induced intestinal injury at home and abroad.

Method used

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  • Ferulic acid drug composition and new application thereof
  • Ferulic acid drug composition and new application thereof
  • Ferulic acid drug composition and new application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0008] Experimental example 1: Take 5.5Gy 60 Changes of peripheral blood picture in ICR mice after Coγ-ray irradiation for 7 days to determine the dosage regimen of ferulic acid

[0009] Peripheral blood picture is the most rapid and significant index that changes after the body is exposed to ionizing radiation, and it is convenient to sample and easy to detect. Preliminary studies found that: 7 days after irradiation, the number of white blood cells in the peripheral blood of the mice dropped to the minimum, and the number of platelets was also significantly reduced. Therefore, this study used the changes in peripheral blood of mice 7 days after irradiation as the main observation index to determine the dosage regimen of the anti-radiation effect of ferulic acid (FA). by figure 2 .B and image 3 .B. It can be seen that 7 days after irradiation, the number of white blood cells in the peripheral blood of mice decreased sharply, which was reduced by (6~18)×10 9 / L reduced to 0.8×1...

experiment example 2

[0013] Experimental example 2: Ferulic acid to 5.5Gy 60 Effects of Coγ-ray irradiation on small intestine injury in ICR mice for 7 days

[0014] 2.1 Pathological changes in the small intestine of mice

[0015] Such as Figure 4 As shown, (Note: #Compared with the normal control group, P 60 Seven days after a single whole body irradiation of Coγ-rays, the small intestine tissue structure of the mice in the irradiated model group was incomplete, the intestinal villi were shortened, and fragments of villi could be seen in the intestinal cavity; small blood vessels in the latent layer of villi were dilated and congested; the glands were irregularly arranged and glands Epithelial cell proliferation, accompanied by the formation of a large number of abnormal cells, lymphocyte proliferation in the gland; the muscle layer is separated from the submucosa. The small intestine tissues of the irradiated mice in the 10, 30, and 90 mg / kg ferulic acid intervention groups gradually recovered to no...

experiment example 3

[0019] Experimental example 3: Ferulic acid to 5.5Gy 60 Effect of HMGB1 distribution in small intestinal villi of ICR mice after Coγ-ray irradiation for 7 days

[0020] Radiation intestinal injury is mainly manifested as acute and chronic radiation enteritis. In view of the fact that HMGB1 in normal cells mainly exists in the nucleus, and the translocation of HMGB1 to the cytoplasm and extracellular fluid is closely related to inflammation, the three-dimensional structures of ferulic acid and HMGB were fitted by computer molecular fitting. The results are shown in Figure 6. Ferulic acid can directly bind to HMGB1, and the binding site is consistent with the binding site of the HMGB1 positive inhibitor on the protein. Therefore, it is speculated that ferulic acid may have the effect of inhibiting ectopic HMGB1. The immunofluorescence method was used to further verify the regulatory effect of ferulic acid on HMGB1 in the small intestinal mucosal cells of mice with radiation-induce...

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Abstract

The invention discloses a composition for preventing and treating radioactive intestinal injuries. The composition comprises ferulic acid converted according to dosage 10-9mg / kg of an experiment mouse. The composition can be prepared into a clinically acceptable dosage form. The composition has an effect of preventing and treating the radioactive intestinal injuries, and the prevention and treatment of the radioactive intestinal injuries refer to improvement of capillary vessel injuries in intestinal villi, promotion of intestinal crypt stem cell proliferation and differentiation, promotion ofmucous epithelial cell regeneration, improvement of a cell state and a function of a hemopoietic system of the irradiated mouse by influencing a Thbd-aPC signal pathway and adjustment of an inflammatory factor HMGB1 (high mobility group box 1).

Description

Technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to a ferulic acid pharmaceutical composition and a new use thereof. Background technique [0002] The intestine is extremely sensitive to radiation and is the most important target organ for radiation damage outside the hematopoietic system. Whether it is medical exposure or accidental exposure, it may cause radiation intestinal injury. Radiation intestinal injury is not only the most important side effect and radiation dose limiting factor in clinical radiotherapy for cancer patients, but also one of the important causes of death in acute radiation sickness patients. 80% of patients with malignant tumors receiving local abdominal and pelvic radiotherapy have common symptoms of different degrees of radiation intestinal injury such as nausea, vomiting, abdominal distension, and mucus and blood in the stool after radiotherapy; after nuclear explosions and nuclear accidents, the intestin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/00
CPCA61K31/192A61P1/00
Inventor 邵帅苏旭田梅刘建香
Owner NAT INST FOR RADIOLOGICAL PROTECTION & NUCLEAR SAFETY CHINESE CENT FOR DISEASE CONTROL & PREVENTION
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