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Application of gentiopicroside in preparation of antiviral medicament

A technology of gentiopicroside and gentian, which is applied in the field of medicine and can solve problems such as no research reports on the effect

Inactive Publication Date: 2007-05-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that gentiopicroside has anti-HBV pharmacological effects, but its anti-CVB 3 There is no research report on the effect of HTNV virus

Method used

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  • Application of gentiopicroside in preparation of antiviral medicament
  • Application of gentiopicroside in preparation of antiviral medicament
  • Application of gentiopicroside in preparation of antiviral medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The pharmaceutical preparation gentiopicroside is prepared into tablets, taking the production of 1000 tablets as an example, the raw materials and auxiliary materials and their weight ratios are as follows:

[0025] Gentiopicroside 200g

[0026] Starch 100g

[0027] or

[0028] Total gentiosides (containing about 70% gentiopicroside) 285g

[0029] Starch 100g

[0030] Its preparation process is carried out according to the conventional process of pharmacy tablets, each tablet weighs 0.3g, and each tablet contains gentiopicroside 200mg. Dosage: Take orally, 1 tablet each time, once a day, reduce as appropriate for children, 30 days is a course of treatment.

Embodiment 2

[0032] The medicinal preparation gentiopicroside is prepared into capsules, taking the production of 1000 capsules as an example, the raw materials and auxiliary materials and their weight ratios are as follows:

[0033] Gentiopicroside 200g

[0034] Starch 100g

[0035] or

[0036] Total gentiosides (containing about 70% gentiopicroside) 285g

[0037] Starch 100g

[0038] Its preparation process is carried out according to the conventional process of pharmaceutical capsules, each capsule weighs 0.3g, and each capsule contains 200mg of gentiopicroside. Dosage: Take orally, 1 tablet each time, once a day, reduce as appropriate for children, 30 days is a course of treatment.

Embodiment 3

[0040] The medicinal preparation gentiopicroside is prepared into granules, taking the production of 1000g of granule products as an example, the raw materials and auxiliary materials and their weight ratios are as follows:

[0041]Gentiopicroside 200g

[0042] Sucrose 400g

[0043] Dextrin 400g

[0044] or

[0045] Total gentiosides (containing about 70% gentiopicroside) 285g

[0046] Sucrose 400g

[0047] Dextrin 400g

[0048] Its preparation process is carried out according to the conventional process of pharmacy granules, each bag weighs 1g, and each bag contains gentiopicroside 200mg. Dosage: Take orally, 1 bag each time, once a day, reduce as appropriate for children, 30 days is a course of treatment.

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PUM

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Abstract

The invention relates to the application of gentian in antiviral drug, while its gentian content is more than 50%, wherein the test has proved that gentian has activity resistant to CVB3 and HFRS. Therefore, the gentian can treat viral myocarditis and nephrotic syndrome. And it can be made into tablet, capsule, etc.

Description

technical field [0001] The invention relates to a new application of gentiopicroside or gentiopicroside containing more than 50% gentiopicroside in antiviral drugs, and belongs to the field of medicine. Background technique [0002] Viral myocarditis (VMC) is a heart disease caused by viral infection and has become an important cause of sudden death in children and adolescents. According to the World Health Organization (WHO) global viral disease surveillance research report, the incidence rate of VMC in newborns and children is 360 / 100,000, and the mortality rate is 8%. According to epidemiological investigations, about 45% to 60% of myocarditis is associated with recent or recurrent Coxsackie virus (CVB 3 ) infection related. CVB 3 Can cause mild upper respiratory tract infection and aseptic encephalitis; lower respiratory tract infection can also be caused in children, but the symptoms are milder. CVB 3 It can adhere to cardiomyocytes, bind to receptors, penetrate ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/515A61K9/08A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61P31/14A61P9/00A61P13/12A61P11/00
Inventor 孙晓莉孙文基王四旺丁媛媛王海波
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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