Preparation method of volatile oil beta-cyclodextrin inclusion compound

Abstract

The invention discloses a preparation method of a volatile oil beta-cyclodextrin inclusion compound, which is characterized in that volatile oil is extracted from capillary artemisia, cabline patchouli, rhizoma atractylodis macrocephaiae, tangerine peel and rhizoma alismatis, and the inclusion compound is prepared through inclusion of beta-cyclodextrin. The volatile oil beta-cyclodextrin inclusion compound prepared in the method has a high inclusion rate.

Description

technical field The invention belongs to the technical field of medicine, and in particular relates to a preparation method of β-cyclodextrin inclusion complex of volatile oil. Background technique Cyclodextrin (CD for short) is a cyclic oligosaccharide compound connected by α-1,4 glycosidic bonds obtained after enzymatic cyclization of starch, and is a good inclusion material. Its main components are 6, 7, and 8 glucose rings called α-CD, β-CD, and γ-CD, respectively. Due to the limitation of enzyme-producing bacteria and separation technology, only β-CD is currently produced and applied in domestic industry. Cyclodextrin has a ring-shaped hollow cylindrical structure, which enables it to form "ultramicrocapsules" with other compound molecules. "Substances, thereby changing the physicochemical properties of the object, play an active role in pharmaceutical formulations. Cyclodextrin not only has good inclusion properties for chemical drugs, but also has extensive research...

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Problems solved by technology

Due to the large dosage of the pill, the disintegration is slow, and its volatile oil is greatly lost in the preparation and storage process, which affects the quality and use of its preparation.

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