Biological active porous structure support suitable for bone regeneration and repair and manufacturing method thereof

Abstract

The invention discloses a biological active porous structure support suitable for bone regeneration and repair.The support comprises an inner support body and an outer support body.The inner support body is surrounded by the outer support body.The inner support body and the outer support body are both a porous support with a completely through internal channel structure.The outer support body has high porosity and high mechanical strength.The inner support body has degradation speed lower than that of the outer support body and has high mechanical strength.The support has good mechanical matching performance, biodegradability and bone tissue repair performance.The shape, the size and the aperture of the support are controllable.Material components and material distribution of the inner support body and the outer support body in the support are controllable.Meanwhile, the invention further provides a manufacturing method of the porous structure support.The method is simple, convenient to use and low in production cost, and the porous support capable of being customized according to bone defect repair and capable of being degraded stage by stage corresponding accordingly to requirements can be obtained.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a bioactive porous structure scaffold suitable for bone regeneration and repair and a manufacturing method thereof. Background technique [0002] With the development of society, bone defect repair has always been a thorny problem for researchers. Various technologies have been invented and applied in the field of bone tissue repair. Bone tissue engineering is a hot spot in the research of bone tissue defect treatment technology. Bone tissue engineering scaffold is one of the key technologies for bone defect repair. At present, people try to construct a bone tissue engineering scaffold that meets the requirements of safety, degradability, and mechanical properties through the compounding of various materials, but the difficulty is relatively high. Therefore, some people start from the structure of the bone scaffold. To study its effect on bone regeneration and repair,...

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Problems solved by technology

[0003] The Chinese invention patent with the authorized notification number CN102784014B discloses a porous bone scaffold, which is formed by bioactive additives, degradable metals, degradable inorganic substances and degradable polymers. The ratio is greater than 97%. At the same time, there are many micropores on the wall of the hole. The diameter of the hole is 100-800 μm, the diameter of the micropore is 5-100 μm, the depth of the hole is 1-50 μm, and the porosity of the porous bone scaffold is 60. ~95%. Although the porous scaffold invented by this technology is conducive to the adhesion of bone tissue cells and the transmission of nutrients, it can effectively fix the cells, and then make them differentiate and multiply, but the mechanical strength of the scaffold is not high. During the degradation process of the scaffold In the middle, its mechanical strength will be further attenuated, resulting in the failure to ensure the integrity of the entire structure, and the possibility of structural collapse

[0004] In addition to the above-mentioned patent documents, most of the scaffold structures currently constructed in the field of bone defect repair are single materials. In order to ensure the rapid growth of bone in the early stage, high porosity and pore diameter are required, but such a design will lead to a significant decrease in the strength of the scaffold structure. , so that in the process of bone ingrowth, the structure will collapse due to insufficient strength, affecting bone ingrowth, because bone tissue grows in through the channel structure built by the bone scaffold, and the degradation of the scaffold is also difficult to match the speed of bone formation Matching, for a scaffold constructed of a single material, the degradation rate of the internal and external structures is the same, which will lead to in some areas of bone tissue repair, the bone tissue has not grown into the scaffold, the scaffold has been degraded, resulting in incomplete bone repair at the defect site , the position of the defect center has not been repaired, or the bone tissue has grown into the scaffold, but due to the degradation of the scaffold, the strength of the scaffold is not enough, and the strength of the new bone tissue has not met the requirements, resulting in the bone tissue in the load-bearing part being damaged again , could not complete the repair

[0005] Therefore, it is necessary to design a scaffold with a new structure, which has high porosity, can promote the rapid growth of bone, but also has high mechanical properties, can bear a certain load and ensure the spatial stability of the scaffold structure, and at the same time , the internal and external structures of the scaffold have different degradation properties. Specifically, the degradation rate of the internal structure is slower, so that bone tissue can grow into the interior of the scaffold structure, and during the degradation process of the scaffold, the scaffold still maintains a high mechanical strength. strength, to ensure complete regenerative repair of bone

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