Mixed porous structure interbody fusion cage and preparation method thereof

A technology of intervertebral fusion and porous structure, which is applied in the field of biomedical engineering, can solve the problems of poor mechanical properties, collapse and fusion rate of non-metallic intervertebral fusion, and achieve good bone conduction and osteoinduction, Good immediate stability, the effect of increasing the contact area

Inactive Publication Date: 2012-05-09
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects of the existing metallic intervertebral cages, such as the mismatch of elastic modulus and poor biological performance, as well as the poor mechanical properties, easy loosening, collapse and low fusion rate of non-metallic intervertebral cages, Provides a mixed porous structure intervertebral fusion device, which can realize the immediate stability of the fusion device, improve its mechanical compatibility with the vertebral body, promote the ingrowth of new bone, and increase the fusion rate

Method used

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  • Mixed porous structure interbody fusion cage and preparation method thereof
  • Mixed porous structure interbody fusion cage and preparation method thereof

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preparation example Construction

[0025] The preparation method of the mixed porous structure intervertebral fusion device of the present invention comprises the following steps:

[0026] The first step is to use the direct metal rapid prototyping technology, and the rapid prototyping equipment uses metal materials for direct metal rapid prototyping under the control of the computer to form a porous metal support 1. The porous metal support 1 has a three-dimensional network structure. A plurality of pores, the size of the pores is 300-1500 μm, and the porosity is 60%-80%.

[0027] In the second step, the microporous polymer is mixed with deionized water to prepare a polymer solution with a concentration of 1%-5%. The microporous polymer is sodium alginate, and then 0.3mol / L of Calcium chloride solution is added to it, the volume ratio of polymer solution and calcium chloride solution is 5:1, so that calcium ion replacement reaction occurs to form a gel solution, and continue to stir for 30-60 minutes to make t...

Embodiment 1

[0033] First, the computer-aided design (CAD) software Unigraphics is used to design the three-dimensional structure of the porous metal support 1. The designed three-dimensional porous structure is a honeycomb structure, the size of the pores is 300 μm, and the porosity is 60%. Then the designed CAD The data is layered and sliced, and converted into the default data format of the rapid prototyping equipment, and then the rapid prototyping equipment processes the data, and uses titanium as the material under computer control for direct metal rapid prototyping to form a porous titanium metal bracket 1 . Mix a certain amount of sodium alginate and deionized water to prepare a polymer solution with a concentration of 1%, and then add 0.3mol / L calcium chloride solution to it under stirring conditions, and the polymer solution and calcium chloride The volume ratio of the solution is 5:1, so that a calcium ion replacement reaction occurs to form a gel solution, and the stirring is c...

Embodiment 2

[0035] First, use the computer-aided design (CAD) software Unigraphics to design the three-dimensional structure of the porous metal support 1. The designed three-dimensional porous structure is a diamond molecular structure, the size of the pores is 700 μm, and the porosity is 70%. Then the designed CAD data Perform layered slicing processing and convert it into the default data format of the rapid prototyping equipment, and then the rapid prototyping equipment uses the titanium alloy for direct metal rapid prototyping manufacturing under computer control according to the processed data to form a porous titanium alloy bracket 1. Mix a certain amount of sodium alginate, hydroxyapatite and deionized water, the mass ratio of sodium alginate and hydroxyapatite is 4:1, prepare a polymer solution with a concentration of 5%, and then , 0.3mol / L calcium chloride solution is added therein, the volume ratio of polymer solution and calcium chloride solution is 5: 1, make it take place ca...

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Abstract

Disclosed are a mixed porous structure interbody fusion cage and a preparation method thereof. The interbody fusion cage comprises a porous metal support and porous structure filling bodies, the porous metal support is a three-dimensional net-shaped structure, a plurality of holes are arranged in the porous metal support, and the porous structure filling bodies are fully filled in the holes. The preparation method includes steps that the metal rapid forming technology is directly combined with the freeze drying technology, the porous metal support is manufactured via a structural design and the direct metal rapid forming technology, then uniformly mixed polymer gel or polymer/ biological ceramic compound gel is poured in the porous metal support to realize freeze treatment, so that the porous structure filling bodies with the micropore feature are formed after freeze drying, and the mixed porous structure interbody fusion cage is obtained. Mechanical compatibility is good, contact area between the mixed porous structure interbody fusion cage and natural centrum is further increased, instant stability is good, fusion rate is improved, and the mixed porous structure interbody fusion cage and the preparation method thereof can be used for treating clinical degenerative disc diseases.

Description

technical field [0001] The invention relates to an orthopedic implant prosthesis, in particular to an intervertebral fusion device with a mixed porous structure and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] Lumbar disc herniation and cervical spondylosis and other symptoms of intervertebral disc degenerative disease is a common and frequently-occurring disease in modern society, seriously affecting the quality of life of patients. Spinal fusion is one of the most widely used techniques in spinal surgery. It mainly promotes spinal fusion by establishing immediate spinal stability and implant osteogenesis, osteoinduction, and osteoconduction. At present, intervertebral fusion has become the main method for the treatment of lumbar instability, lumbar spinal stenosis, degenerative spondylolisthesis, degenerative scoliosis, pseudarthrosis and degenerative disc disease. There are two main types of inter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44A61L27/56
CPCA61F2/44A61F2002/30001
Inventor 李祥罗云
Owner SHANGHAI JIAO TONG UNIV
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