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Polyurethane medical compound film and preparation method thereof

A polyurethane and composite membrane technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problem of lack of biological activity, and achieve the effect of conduction bone growth, convenient use and excellent biocompatibility

Inactive Publication Date: 2009-03-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although polyurethane has good biocompatibility, its lack of bioactivity to bond with bone is the main problem when it is applied to bone tissue repair and reconstruction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 20 g of polyoxypropylene diol (molecular weight 1000) and 25 g of polycaprolactone diol (molecular weight 1250), stir evenly, heat up to 80°C, and add 4,4'-methylene dicyclohexyl diol dropwise under nitrogen protection. Isocyanate (HMDI) 21.6g, and add 80mg stannous octoate to react for 3.5h to prepare polyurethane prepolymer. Cool down to 40°C, use acetone to prepare the polyurethane prepolymer into a solution with a concentration of 40%, add 3.6ml of 1,4-butanediol, and add N,N-dimethylformamide of nano-hydroxyapatite after half an hour Slurry 86g (the mass fraction of n-HA is 35%), compound under full stirring, add deionized water after 3-4 hours, stir evenly, cast into film, the addition of water is the polyurethane prepolymer content in the solution 1.8%. Then remove the solvent at 55°C, cure at room temperature for 24 hours, then soak in deionized water for 2-4 hours, and carefully peel off to obtain a medical composite film of aliphatic polyurethane with a ...

Embodiment 2

[0034] Get polyoxypropylene trihydric alcohol (molecular weight 1500) 15g, polycarbonate dihydric alcohol (molecular weight 1000) 20g, stir evenly, heat up to 70 ℃, under nitrogen protection, dropwise add isophorone diisocyanate (IPDI) 16g, Add 50 mg of triethylenediamine and react for 4 hours to obtain a polyurethane prepolymer; cool down to 35°C, and use a mixed solvent of ethyl acetate / N,N-dimethylformamide (volume 1:1) to prepolymerize the polyurethane The body is prepared into a solution with a concentration of 45%, adding 3.5ml of diethylene glycol, and adding nano-hydroxyapatite N,N-dimethylformamide slurry 90g after 1 hour (n-HA mass fraction is 40 %), compound under fully stirred state, add deionized water after 3-4 hours, stir evenly, and cast to form a film, the addition of water is 1.5% of the polyurethane prepolymer content in the solution. Then remove the solvent at 50°C, cure at room temperature for 24 hours, soak in deionized water for 2-4 hours, and carefully ...

Embodiment 3

[0036] Polytetrahydrofuran ether (molecular weight: 2000) 30g, castor oil (molecular weight: 932) 6.9g, stir evenly, heat up to 80°C, add lysine diisocyanate (LDI) 10.9g dropwise under nitrogen protection, and add 50mg dibutyltin dilaurate acid ester, and reacted for 3.5h to obtain a polyurethane prepolymer. Cool down to 50°C, use N,N-dimethylacetamide to prepare the polyurethane prepolymer into a solution with a concentration of 30%, add 2.5ml hexanediol, and add nano-hydroxyapatite N,N- 100g of dimethylformamide slurry (the mass fraction of n-HA is 25%), compound under the state of full stirring, add deionized water after 3-4 hours, stir evenly, coat and form a film, the amount of water added is the solution 1% of the polyurethane prepolymer content in the medium. Then remove the solvent at 55°C, cure at room temperature for 24 hours, then soak in deionized water for 2-4 hours, and carefully peel off to obtain a medical composite film of aliphatic polyurethane with a thickn...

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Abstract

The invention relates to a medical polyurethane complex film and the preparation method thereof. The complex film is composed of fatty group polyurethane and nanometer hydroxylapatite, wherein the content of the anometer hydroxylapatite is 20-50 wt percent. The fatty group polyurethane is polymerized by at least one of fatty group vulcabond and polyether or polyester polyol, wherein the mol ratio of the fatty group vulcabond-NCO and -OH in the polyol is 1.5-3 to 1. The film belongs to a thermoplasticity elastic film, has favorable elasticity and easy moulding, can load microspheres containing medicine or active components such as biological nutrilit and the like and structures distributed with through holes, thereby having favorable biological performance, and the film does not contain aromatic components but contains ester groups and / or hydrophilic ether groups which can be hydrolyzed or biologically degraded; the hydrophile and hydrophobic nature balance and the degradation of the film can be changed through adjusting the proportion, and the film can be applied to the medical health field of bone tissue guiding regeneration film and medicine slow-released film, and the like.

Description

technical field [0001] The invention relates to a polyurethane medical composite film, in particular to a medical film composited by aliphatic polyurethane and nano-hydroxyapatite and a preparation method thereof. Background technique [0002] Bone defects and nonunions have always been difficult problems for clinical orthopedic surgeons. In order to explore and solve the problems of bone defect and bone nonunion, scholars at home and abroad have made unremitting efforts. The research and development of Guided Bone Regeneration (GBR) provides a new idea for solving clinical problems such as bone defect and fracture nonunion in medicine, and gradually arouses the interest of researchers. The key to the GBR technology is the GBR barrier membrane, which can be used as a mechanical barrier membrane to selectively separate the bone from the surrounding soft tissue, prevent epithelial cells and fibroblasts from growing into the bone defect, and thus make the osteogenic potential ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/18A61L15/62
Inventor 张利刘浩怀李玉宝
Owner SICHUAN UNIV
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