Guided tissue regeneration membrane and preparation method thereof

A technology to guide tissue regeneration and periosteum, applied in medical science, surgery, etc., can solve the problems of increased trauma opportunities, short degradation cycle, poor bone regeneration, etc., to achieve extended degradation cycle, improved degradation performance, good water absorption and flexibility Effect

Active Publication Date: 2019-11-08
北京奥精医疗器械有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the late 1970s and early 1980s, Nyman, Gottlow and Becker successively conducted research on non-degradable materials such as polyacetal, polytetrafluoroethylene, and silicone membranes. Capacitive, but there are many disadvantages: (1) it cannot be absorbed by the tissue, requiring a second operation to remove the material, which increases the chance of trauma; (2) the non-absorbable membrane has a significant risk of early exposure, which may lead to wound infection and subsequent wound infection. The results of poor bone regeneration; (3) due to the rigidity and hydrophobicity of the non-absorbable membrane, it must be fixed with screws during the operation
[0006] The patent application document with the application publication number CN106492283A discloses a two-layer structure guiding tissue regeneration membrane composed of a loose layer and a dense layer and having a certain effect of inducing bone production and isolating surrounding soft tissue, but the material is relatively poor in adhesion , its degradation cycle is short, and there is a certain degree of swelling after hydration

Method used

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  • Guided tissue regeneration membrane and preparation method thereof
  • Guided tissue regeneration membrane and preparation method thereof
  • Guided tissue regeneration membrane and preparation method thereof

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preparation example Construction

[0090] In a second aspect, the present invention provides a method for preparing a guided tissue regeneration membrane, the preparation method comprising: (1) a step of preparing mineralized collagen nanoparticles; (2) a step of preparing a dense layer; (3) The step of preparing a loose layer on the surface of the layer; (4) the step of roll forming; and (5) the step of crosslinking.

[0091] For step (1), existing methods can be used to prepare mineralized collagen nanoparticles. Of course, it is better to adopt the following method provided by the present invention to prepare mineralized collagen nanoparticles:

[0092] (11) Dissolving type I collagen in any one of hydrochloric acid, nitric acid or acetic acid to prepare a collagen acid solution with a concentration of 0.01-0.2 g / mL;

[0093] (12) Adding calcium salt solution dropwise to the collagen acid solution, the amount of calcium ions added is 0.1 to 2 mol of calcium ions corresponding to each gram of collagen;

[0...

Embodiment 1

[0124] S1, preparation of mineralized collagen particles:

[0125] S1-1. Dissolving type I collagen in hydrochloric acid to prepare collagen acid solution, wherein the concentration of collagen is 0.1g / mL;

[0126] S1-2. Add calcium salt solution dropwise to the collagen acid solution, wherein the amount of calcium ions added is 1 mol of calcium ions corresponding to each gram of collagen;

[0127] S1-3. Add phosphoric acid solution dropwise to the solution obtained in S1-2, wherein the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in S1-2 is Ca / P=1.5 / 1;

[0128] S1-4. Add NaOH solution dropwise to the solution obtained in S1-3 to form a mixed solution, and adjust the pH value to 6.5±0.5;

[0129] S1-5. After the mixed solution obtained in S1-4 was left to stand for 8 hours, the precipitate was centrifuged at a speed of 4000 r / min and then air-dried at 60° C. for 60 hours to obtain mineralized collagen nanoparticles.

[0130] S2, p...

Embodiment 2

[0175] Preparation method is basically the same as Example 1, except that:

[0176] In S1,

[0177] S1-1. Dissolving type I collagen in hydrochloric acid to prepare collagen acid solution, wherein the concentration of collagen is 0.02g / mL;

[0178] S1-2. Add calcium salt solution dropwise to the collagen acid solution, wherein the amount of calcium ions added is 0.1 mol of calcium ions per gram of collagen;

[0179] S1-3. Add phosphoric acid solution dropwise to the solution obtained in S1-2, wherein the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in S1-2 is Ca / P=1 / 1.

[0180] In S2,

[0181] S2-1, dissolving type I collagen in purified water, stirring for 15 hours, and preparing the first collagen aqueous solution, wherein the mass concentration of collagen is 0.01%;

[0182] S2-2. Coat the first aqueous collagen solution obtained in S2-1 on a polytetrafluoroethylene plate, and cast it smoothly, wherein the coating quality of the f...

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Abstract

The invention relates to a guided tissue regeneration membrane and a preparation method thereof. The guided tissue regeneration membrane comprises a dense layer and a porous layer. After the dense layer and the porous layer are compounded, a composite material is sequentially rolled and cross-linked. The preparation method comprises the steps of (1) preparing mineralized collagen nanoparticles, (2) preparing the dense layer, (3) preparing the porous layer on the surface of the dense layer, (4) rolling forming and (5) crosslinking. The guided tissue regeneration membrane has better operation performance and tissue repair performance, namely, on the premise of ensuring that the material has good water absorption, flexibility and tissue repair, the mechanical properties of the material are better, the swelling rate after water absorption is reduced, and a degradation cycle is more matched with a growth cycle of a new bone tissue.

Description

technical field [0001] The invention relates to the technical field of medical device materials, in particular to a membrane for guiding tissue regeneration and a preparation method thereof. Background technique [0002] The concept of guided tissue regeneration was first proposed by Nyman et al. It refers to relying on mechanical barriers to selectively guide cells to attach and proliferate to damaged parts to achieve the purpose of tissue repair. In reconstructive orthopedic surgery, a barrier membrane is implanted to prevent the growth of connective soft tissue into the bony defect. In principle, the barrier membrane is in direct contact with the bone surface around the bone defect, and the periosteum is located on the outer surface of the barrier membrane. The mucoperiosteal flap is then repositioned and sutured to form an isolated space that only surrounding bone tissue cells can enter. In oral surgery procedures, application of barrier membranes has become routine fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04A61L31/14
CPCA61L31/044A61L31/127A61L31/146A61L31/148C08L89/00
Inventor 崔云宋天喜李良才李洪景朱艳泽仇志烨
Owner 北京奥精医疗器械有限责任公司
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