Novel use of ploy-L-lactic acid as medical shape memory material

A technology of memory materials and new uses, applied in medical science, medical containers, medical packaging, etc.

Inactive Publication Date: 2005-01-26
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After literature search, it was found that D-lactide and L-lactide were ring-opened and polymerized in a molar ratio of 1:1 to obtain poly-D, L-lactic acid copolymer and poly-

Method used

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specific Embodiment approach 1

[0004] Specific embodiment 1: Poly L-lactic acid is molded into an initial shape at a temperature of 190-210°C and a pressure of 2-1 MPa to obtain poly-L-lactic acid with shape memory properties, and the obtained poly-L-lactic acid is used for medical purposes Shape-memory materials can be used, and the use method of the obtained medical shape-memory materials is as follows: apply deformation above the glass transition temperature to form a secondary shape, cool to below the glass transition temperature to freeze and deform; reheat to above the glass transition temperature, The material returns to its original shape. The poly L-lactic acid can be produced by ring-opening polymerization of L-lactide, and the medical shape memory materials used include blood vessel binding materials, tendon binding materials, surgical sutures, fracture fixation materials or interventional bracket materials.

specific Embodiment approach 2

[0005] Embodiment 2: In this embodiment, the medical shape memory material also includes a copolymer of poly-L-lactic acid, that is, a copolymer formed by copolymerization of L-lactide and other lactide, lactone or ether segments of comonomers, so The comonomer is DL-lactide, glycolide, ε-caprolactone, ethylene glycol or dioxanedione.

specific Embodiment approach 3

[0006] Specific embodiment three: In this embodiment, the medical shape memory material also includes a polymer blend formed by blending poly-L-lactic acid and aliphatic polyester and / or polyether, and the aliphatic polyester is polyDL-lactic acid , Polyε-caprolactone, polyether is polyethylene glycol.

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Abstract

A novel usage of poly-L-lactic acid as medical shape memory material is provided. Forming the poly-L-lactic acid to initial shape under the temperature of 190í½210íµ and pressure of 2í½10Mpa to obtain the poly-L-lactic acid with shape memory property. The present invention uses poly-L-lactic acid as medical degradable shape memory material for the first time. It can be widely applied in minor trauma invasive stent, vessel jointing, operation suture line, bone fracture fixation and other medical field.

Description

Technical field: [0001] The invention relates to a new application of poly L-lactic acid. Background technique: [0002] Polylactic acid is an important biomedical polymer material with good biocompatibility and bioabsorbability. It has been widely used in fracture internal fixation, tissue engineering scaffolds, surgical sutures, and drug controlled release systems. application. Polylactic acid is usually synthesized by ring-opening polymerization of lactide. According to different optical activities, lactide is divided into D-lactide, L-lactide and DL-lactide, and the ring-opening polymerization products are corresponding For poly D-lactic acid, poly L-lactic acid and poly DL-lactic acid. After literature search, it was found that D-lactide and L-lactide were ring-opened and polymerized in a molar ratio of 1:1 to obtain poly-D, L-lactic acid copolymer and poly-DL-lactic acid synthesized from DL-lactide. Shape memory properties, but there is no report about the shape mem...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L33/06C08L67/04
Inventor 蔡伟鲁玺丽赵连城
Owner HARBIN INST OF TECH
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