Injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and preparation method thereof

A technology of polymethyl methacrylate and composite scaffolds, applied in medical science, prostheses, etc., can solve the problems of mismatching mechanical properties with natural bone, high polymerization temperature, and shedding of surrounding tissues, so as to reduce the cost of treatment , mechanical characteristics matching, and the effect of improving the success rate

Active Publication Date: 2015-09-16
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the course of long-term clinical practice, some disadvantages of PMMA have gradually been exposed, such as mechanical properties that do not match natural bone, poor osseointegration, high polymerization temperature, infection, etc. Gradual loosening, detachment, and necrosis of surrounding tissue occur during the remodeling process, which may eventually lead to graft failure

Method used

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  • Injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and preparation method thereof
  • Injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and preparation method thereof
  • Injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Dissolve chitosan (CS) in 0.1mol / L hydrochloric acid solution at room temperature to prepare CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0043] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a GP solution with a mass concentration of 50%, and also place it in an ice bath for 15 minutes.

[0044] (3) Under continuous stirring, slowly drop 0.5mL GP solution into 4.5mL CS hydrochloric acid solution, keep the solution without turbidity, and stir for 20min to obtain a well-mixed CS-GP solution.

[0045] (4) Add 25mg of gentamicin sulfate (GM) and 300mg of hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonically treat it to make it evenly mixed to obtain CS-GP / Nano-HA / GM mixture.

[0046] (5) Put the CS-GP / Nano-HA / GM mixed solution in a 37°C incubator, and form a CS-GP / Nano-HA / GM gel after 5 minutes.

[0047] (6) CS-GP / Na...

Embodiment 2

[0050] (1) Dissolve chitosan (CS) in 0.1mol / L hydrochloric acid solution at room temperature to prepare CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0051] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a GP solution with a mass concentration of 50%, and also place it in an ice bath for 15 minutes.

[0052] (3) Under continuous stirring, slowly drop 0.5mL GP solution into 4.5mL CS hydrochloric acid solution, keep the solution without turbidity, and stir for 20min to obtain a well-mixed CS-GP solution.

[0053] (4) Add 25mg of vancomycin (VM) and 300mg of hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonically treat it to make it evenly mixed to obtain a CS-GP / Nano-HA / VM mixed solution .

[0054] (5) Put the CS-GP / Nano-HA / VM mixed solution in a 37°C incubator, and form a gel after 5 minutes.

[0055] (6) CS-GP / Nano-HA / VM gel wa...

Embodiment 3

[0058] (1) Dissolve chitosan (CS) in 0.1mol / L hydrochloric acid solution at room temperature to prepare CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0059] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a GP solution with a mass concentration of 50%, and also place it in an ice bath for 15 minutes.

[0060] (3) Under continuous stirring, slowly drop 0.5mL GP solution into 4.5mL CS hydrochloric acid solution, keep the solution without turbidity, and stir for 20min to obtain a well-mixed CS-GP solution.

[0061] (4) Add 25mg of gentamicin sulfate (GM) and 300mg of hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonically treat it to make it evenly mixed to obtain CS-GP / Nano-HA / GM mixture.

[0062] (5) Put the CS-GP / Nano-HA / GM mixed solution in a 37°C incubator, and form a CS-GP / Nano-HA / GM gel after 5 minutes.

[0063] (6) Stir and...

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Abstract

The present invention discloses an injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and a preparation method thereof, and belongs to the field of organic functional materials preparation. The polymethyl methacrylate-based composite scaffold bone transplant material uses polymethyl methacrylate (PMMA) as a scaffold for providing mechanical supporting, and a chitosan-based thermosensitive hydrogel as a pore forming agent and an osteoconductive material and a drug carrier, and the polymethyl methacrylate (PMMA) and the chitosan-based thermosensitive hydrogel are mixed with each other to form an injectable-porous three-dimensional structural bone cement composite. The scaffold bone transplant material is simple in preparation method, suitable in reaction temperature, and good in biocompatibility, has matched mechanical properties, good biological mineralization and corresponding anti-bacterial, anti-inflammatory or anti-tumor capabilities, and has broad prospects in clinical application of reconstruction of bone tissues in future.

Description

technical field [0001] The invention belongs to the field of preparation of organic functional materials, in particular to an injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and a preparation method thereof. Background technique [0002] Bone transplantation has been committed to repairing large-scale bone defects caused by trauma, tumors, infections, etc., so as to restore body function and appearance, and is one of the most common transplant operations. Bone transplantation is divided into autologous bone transplantation, allogeneic bone transplantation and artificial bone substitute material transplantation according to the source of the graft. Autologous bone grafting is the gold standard for bone repair and reconstruction. However, due to the limited source, secondary trauma, and inability to provide initial stability, its clinical application is greatly limited. The cost of allograft bone grafting is high and the quan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/16A61L27/20A61L27/12A61L27/10
Inventor 撒悦蒋滔王曼
Owner WUHAN UNIV
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