Preparation method of hydroxyapatite/sodium alginate nano composite material

A nanocomposite material, hydroxyapatite technology, applied in medical science, prosthesis, etc., can solve the problem of weak bonding force between inorganic and organic phase interfaces, difficulty in uniform dispersion of HA particles, mechanical properties that cannot reach the weight-bearing bones of the human body, etc. problems, to achieve the effect of improving biodegradable absorption function, good biological characteristics and plasticity, and good biocompatibility

Inactive Publication Date: 2009-05-06
CHINA NAT ACAD NANOTECH & ENG
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Problems solved by technology

[0005] The above-mentioned preparation methods are basically the mechanical mixing of HA particles and sodium alginate in a certain proportion. In the composite material obtained in this way, it is difficult to achieve uniform dispersion of HA particles in the sodium alginate matrix, and the lack of chemical bonding between the two causes The interface between inorganic and organic phases has weak bonding force, it is difficult to form a multi-level structure similar to natural bone, and its mechanical properties cannot meet the requirements of human load-bearing bone

Method used

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Embodiment

[0018] 1) Weigh 5.16g of calcium hydroxide, add 65g of deionized water, and prepare a calcium hydroxide suspension with a concentration of 7.4% by weight; weigh 4.82g of 85wt% phosphoric acid, add 50ml of deionized water, and prepare a concentration of 7.6% by weight % phosphoric acid solution;

[0019] 2) Weigh 3.00 g of sodium alginate, add 77 g of deionized water, stir magnetically for 1 hour, and prepare a sodium alginate hydrogel with a concentration of 3.8% by weight;

[0020] 3) Add the sodium alginate hydrogel prepared in (2) dropwise to the Ca(OH) hydrogel prepared in (1) under the electric stirring condition 2 in suspension;

[0021] 4) Slowly add the phosphoric acid solution prepared in (1) dropwise into the mixed solution obtained in (3) under electric stirring conditions, and continuously stir and react at room temperature and normal pressure for 6 hours;

[0022] 5) Add 10 ml of a 0.1 mol / L calcium chloride solution dropwise to the mixture obtained in (4) to cr...

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Abstract

The invention relates to a preparation method of a hydroxylapatite/sodium alginate nanometer composite material, which mixes calcium hydroxide and phosphoric acid water solution according to the chemical stoichiometric ratio of Ca/P in the hydroxylapatite and carries out the in-situ composite reaction with sodium alginate water gel, and a three dimensional net shaped structure similar to a natural bone is formed by adding calcium chloride to realize the intercrossing reaction with the sodium alginate. The method has the advantages that: the hydroxylapatite/sodium alginate nanometer composite material maintains the good biological compatibility, biological activity and bone conductibility of HA; the combination of the sodium alginate as an organic substrate with the HA can bestow the HA good processing and forming property, thus effectively inhabiting the moving of HA particles from the transplanting parts; and the sodium alginate has rich source and low price, and the preparation process can be operated at normal temperature and pressure, and has simple operation and low cost, and is an ideal bone repairing substitute materials of the new generation.

Description

(1) Technical field [0001] The invention relates to the technical field of bone repair biomedical materials, in particular to a method for preparing a hydroxyapatite / sodium alginate nanocomposite material. (2) Background technology [0002] Hydroxyapatite (HA for short), its molecular formula is Ca 10 (PO 4 ) 6 (OH) 2 , is the main inorganic component of human bone tissue and teeth. The substance has good biocompatibility and is non-toxic and has no immune rejection. After implanted in the body, it can form a strong chemical bond with the surrounding bone tissue and induce new bone growth. It is an ideal human body. Alternative materials for hard tissue repair. However, the mechanical properties of a single HA material are poor, such as high brittleness, difficulty in processing and molding, and easy migration of HA particles from the transplantation site. These shortcomings largely limit its application in bone replacement at load-bearing sites. Therefore, artificiall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/12
Inventor 王莉范洪涛陈江波
Owner CHINA NAT ACAD NANOTECH & ENG
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