Medical titanium alloy with antibacterial and osteocyte-facilitating functions and preparation method thereof

A titanium alloy, bone-promoting technology, used in medical science, metal material coating technology, prosthesis, etc., can solve the problems of irregular surface morphology of the passivation layer, unable to form bony bonds, etc., to achieve good detection of antibacterial and osseointegration performance, good short-term antibacterial performance, strong controllability effect

Inactive Publication Date: 2014-08-27
CHONGQING UNIV
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Problems solved by technology

[0003] A layer of TiO2 passivation layer is spontaneously formed on the titanium-based surface, which can improve the biocompatibility and corrosion resistance of titanium metal, but the spontaneously formed passivation layer has irregular surface morphology. When implanted into the human body, new bone tissue an

Method used

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  • Medical titanium alloy with antibacterial and osteocyte-facilitating functions and preparation method thereof
  • Medical titanium alloy with antibacterial and osteocyte-facilitating functions and preparation method thereof
  • Medical titanium alloy with antibacterial and osteocyte-facilitating functions and preparation method thereof

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Embodiment 1

[0028] The titanium alloy surface promotes osteoblast function-the functional structure construction of antibacterial properties, including the following steps:

[0029] a. Preparation of chitosan-lauric acid conjugate: first, prepare chitosan (concentration is 1%) with 0.5% acetic acid solution, magnetically stir overnight, prepare lauric acid solution with methanol, concentration is respectively 1%, 1.67 %, 2.5%, prepare EDC (125mM) solution with double distilled water, add gradient lauric acid solution (volume ratio is 1:5), in order to activate the carboxyl group of lauric acid, magnetically stir for 4h; Add the solution dropwise into the chitosan solution (volume ratio is 3:5), stir magnetically for 24 hours, and generate a white suspension; then transfer the suspension into a dialysis bag, dialyze for three days, freeze, and dry to obtain the shell Glycan-gradient lauric acid conjugates.

[0030] b. Fixation of polydopamine: use chemical fixation method to fix the polyd...

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Abstract

The invention provides a preparation method of nanolayer medical titanium alloy with antibacterial and osteocyte-facilitating functions. The method comprises the following steps: firstly, preparing different concentrations of chitosan-lauric acid (1%, 1.67% and 2.5%) conjugates by esterification reaction; secondly, utilizing a physical adsorption method and a chemical fixation method, adopting poly-dopamine as an intermediate layer, fixing the chitosan-lauric acid conjugates on the surface of a titanium implant, so as to build a nano structure layer with dual antibacterial and osteocyte proliferation facilitating properties on the titanium material surface, so as to regulate and control the biological function of the osteocyte, and improve the short-term antimicrobial capability of the titanium implant.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a preparation method of a functional titanium alloy interface. Background technique [0002] Titanium and titanium alloy implants are widely used in surgical operations such as bone repair because of their excellent mechanical properties and good biocompatibility. Then, after the titanium graft is implanted in the body, it combines with the bone in a mechanically integrated manner. This passive method will cause inflammation, displacement, and eventually lead to graft failure. In order to solve this problem, surface modification of titanium to improve its osseointegration has become an important content in the research field of medical materials. [0003] A layer of TiO2 passivation layer is spontaneously formed on the titanium-based surface, which can improve the biocompatibility and corrosion resistance of titanium metal, but the spontaneously formed passivation layer has irre...

Claims

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Application Information

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IPC IPC(8): C23C22/64A61L27/40A61L27/20A61L27/06A61L27/18A61L27/54
Inventor 蔡开勇赵璐
Owner CHONGQING UNIV
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