Medical titanium alloy with antibacterial and osteocyte-facilitating functions and preparation method thereof

Abstract

The invention provides a preparation method of nanolayer medical titanium alloy with antibacterial and osteocyte-facilitating functions. The method comprises the following steps: firstly, preparing different concentrations of chitosan-lauric acid (1%, 1.67% and 2.5%) conjugates by esterification reaction; secondly, utilizing a physical adsorption method and a chemical fixation method, adopting poly-dopamine as an intermediate layer, fixing the chitosan-lauric acid conjugates on the surface of a titanium implant, so as to build a nano structure layer with dual antibacterial and osteocyte proliferation facilitating properties on the titanium material surface, so as to regulate and control the biological function of the osteocyte, and improve the short-term antimicrobial capability of the titanium implant.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a preparation method of a functional titanium alloy interface. Background technique [0002] Titanium and titanium alloy implants are widely used in surgical operations such as bone repair because of their excellent mechanical properties and good biocompatibility. Then, after the titanium graft is implanted in the body, it combines with the bone in a mechanically integrated manner. This passive method will cause inflammation, displacement, and eventually lead to graft failure. In order to solve this problem, surface modification of titanium to improve its osseointegration has become an important content in the research field of medical materials. [0003] A layer of TiO2 passivation layer is spontaneously formed on the titanium-based surface, which can improve the biocompatibility and corrosion resistance of titanium metal, but the spontaneously formed passivation layer has irre...

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Problems solved by technology

[0003] A layer of TiO2 passivation layer is spontaneously formed on the titanium-based surface, which can improve the biocompatibility and corrosion resistance of titanium metal, but the spontaneously formed passivation layer has irregular surface morphology. When implanted into the human body, new bone tissue and Implants can only grow by contact and cannot form a strong bony bond

In order to obtain ideal biomaterials, make the implantation time longer, have a long-lasting effect, and be organically combined with the body, the antibacterial and biocompatibility properties of titanium materials still need to be improved.

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