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Acoustic-sensitive stent with restricture proof function

A technology of restenosis and function, applied in the field of biomedical engineering, which can solve problems such as inconvenience of clinical application

Inactive Publication Date: 2007-03-28
许川山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, light-activated sensitizers often need to directly irradiate diseased tissues, especially in deep cavities in the body, which often require fiber-guided transmission, which brings a lot of inconvenience to clinical applications.

Method used

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  • Acoustic-sensitive stent with restricture proof function
  • Acoustic-sensitive stent with restricture proof function
  • Acoustic-sensitive stent with restricture proof function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Observation of the effect of sound-sensitizer-mediated sonodynamic action on the proliferation activity of vascular smooth muscle cells on cultured cells in vitro: select vascular smooth muscle cells as target cells, and routinely culture them with DMEM culture medium containing 10% calf serum at 37°C In an incubator containing 5% carbon dioxide and saturated water vapor; then, take the target cells in the logarithmic growth phase (2×10 4 ) cells, add a sound-sensitizer such as hematoporphyrin and incubate for 12 to 16 hours in an incubator containing 5% carbon dioxide and saturated water vapor at 37°C, because some hematoporphyrin may not be phagocytized by the target cells and remain free in the culture medium Therefore, before ultrasonic irradiation, wash several times to remove residual hematoporphyrin in the culture medium; then, apply ultrasonic (frequency is 1MHz, sound intensity is 0.25-2.5W / cm 2 ) to irradiate target cells. Under the action of ultra...

Embodiment 2

[0018] Example 2: Pour the sound sensitizer aloe-emodin into absolute ethanol, mix well and then filter and ultrasonically exhaust to make an aloe-emodin solution; After soaking in the solution for 10 seconds to 4 hours, take it out; dry it with nitrogen; repeat the above steps 1-3 times, and finally dry it with nitrogen to obtain the sound-sensitive bracket as shown in Figure 4.

[0019] In this Example 2, the selected sonosensitizer is a safe and non-toxic photosensitizer that can selectively localize to hyperplastic tissue cells. In addition to aloe-emodin, it can also be aluminum phthalocyanine, 5-aminoacetyl Propionic acid, hypocretin derivatives, monoasparagine chlorin, dexaphenanthium lutetium, rose bengal, hematoporphyrin, or hematoporphyrin monomethyl ether, etc.

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Abstract

The present invention belongs to the field of biomedical engineering technology, in the concrete, it relates to a sound-sensitive scaffold with the function of preventing and curing restructure. It is characterized by that a sound-sensitive agent is used to modify the scaffold so as to obtain sound-sensitive scaffold. When it is used, the sound-sensitive scaffold is placed in the pathological lumen, and irradiated by ultrasonic wave for a proper time, so that the sound-sensitive agent on the scaffold can be activated so as to produced phonochemical reaction to form active oxygen substance, resist endometrial hyperplasia and prevent production of scaffold restructure.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and more specifically, the invention relates to an acoustic-sensitive stent with the function of preventing restenosis. Background technique [0002] Endovascular stent implantation is an interventional treatment technology developed on the basis of endovascular angioplasty, and it has been widely used clinically. In the United States alone, there are nearly 100,000 cases of endovascular stent implantation a year. With the accumulation of clinical follow-up data, the postoperative restenosis rate is as high as 30-50%. Reducing restenosis after endovascular stent implantation is a clinical problem to be solved urgently. [0003] In recent years, with the rapid development of cell biology and molecular biology, some progress has been made in the research on the mechanism of restenosis after endoplasty. Studies have shown that early elastic recoil, vascular remodeling and stent-indu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16A61L27/54A61L27/40A61F2/82
Inventor 许川山王志刚
Owner 许川山
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