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Blood contact type functional material as well as preparation method and application thereof

A technology of functional materials and blood, applied in medical science, surgery, coating, etc., can solve problems such as loss of coating function, coating wear, weak bonding force, etc., and achieve excellent resistance

Pending Publication Date: 2021-05-28
CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, during the installation and implantation of nickel-titanium self-expanding stents, on the one hand, there will be huge deformation and continuous friction with the sheath. Insufficient ability and wear resistance, the coating wears and falls off during the implantation process, resulting in the loss of coating function, and in severe cases, local acute thrombosis will be caused by the local coating falling off, leading to serious clinical complications, which limits the nickel Application and Development of Organic Functional Coating on Titanium Alloy Surface

Method used

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  • Blood contact type functional material as well as preparation method and application thereof
  • Blood contact type functional material as well as preparation method and application thereof

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preparation example Construction

[0021] An embodiment of the present invention provides a method for preparing a blood-contact functional material, which includes the following steps:

[0022] Polyphenol compounds with carboxyl functional groups and polyamine molecules are dissolved in carbodiimide reaction system, and polyamine adhesion molecules modified with polyphenol compounds are constructed through condensation reaction; polyamine modified with polyphenol compounds Adhesion-like molecules are soluble in water and undergo oxidative polymerization under alkaline conditions to form an amino-rich poly(phenol-amine) coating on the substrate; Coating modified substrates for covalent grafting of heparin.

[0023] The inventors found that when the functional material is used as a material for vascular stents, not only does it not have the problem of loss of heparin functional molecules modified at this part due to coating scratches and shedding caused by huge deformation and friction during the implantation pr...

Embodiment 1

[0040] This embodiment provides a blood-contact functional material, including the following steps:

[0041] (1) Dissolve 0.5mg / mL of hydrocaffeic acid and 5mg / mL of polyallylamine (molecular weight is about 10000Da) in 9.76mg / mL of 2-(N-morpholine)ethanesulfonic acid (MES), 1mg / mL of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and 0.24 mg / mL of N-hydroxysuccinamide (NHS) in a solution (pH 5.6), After reacting for 12 hours and dialysis in pure water for 24 hours, polyamine-based adhesion molecules modified by polyphenol compounds (marked as HCAPA) were obtained. Subsequently, the peripheral vascular stent is placed in a Tris (pH value 8.5) buffer solution containing 5 mg / mL of HCAPA, reacted at room temperature for 12 hours, and a layer of surface-rich amine-based coating (marked as PHCAPA).

[0042] (2) Prepare 50mL MES buffer solution (concentration is 10mg / mL), add EDC, NHS and heparin molecule (Hep), the concentration is 0.1mg / mL, 0.24mg / mL, 0.2mg / mL respective...

Embodiment 2

[0044] This embodiment provides a method for preparing blood-contact functional materials, including the following steps:

[0045] (1) Dissolve gallic acid and polylysine (molecular weight is about 1000Da) in 2-(N-morpholine) ethanesulfonic acid, 1-ethyl-3-(3-dimethylaminopropyl) In the acidic solution that carbodiimide and N-hydroxysuccinamide form, control gallic acid, polylysine, 2-(N-morpholine) ethanesulfonic acid, 1-ethyl-3-( The concentrations of 3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinamide were 0.01mg / mL, 0.01mg / mL, 9.5mg / mL, 0.5mg / mL, 0.2mg / mL, and the reaction time for 6 hours. After the reaction is completed, polyphenol-modified polyamine molecules are obtained.

[0046] (2) The peripheral vascular stent is placed in a Tris (pH 7) buffer solution containing 0.1 mg / mL polyphenol-modified polyamine molecules, and reacted at room temperature for 6 hours, that is, a layer of surface is obtained on the surface of the peripheral vascular stent Amine-ric...

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Abstract

The invention discloses a blood contact type functional material as well as a preparation method and application thereof, and belongs to the field of medical instruments. The blood contact type functional material comprises a polyamine-phenol coating layer rich in amino groups and heparin functional molecules covalently grafted by utilizing the amino groups on the surface of the polyamine-phenol coating layer. It is found that when the functional coating layer is used as a surface coating layer of a blood contact implantation and interventional instrument, the functional coating layer can bear huge deformation caused by the device in the application process, and the problem that the functional molecules of heparin modified at the part are lost due to scratch and falling of the coating layer caused by friction is solved. The long-term antithrombotic function of the instrument is maintained in the application process due to the persistent high-activity retention and high-density grafting quality of the heparin on the surface of the instrument, surface endothelium regeneration of the interventional instrument such as a peripheral vascular stent can be promoted, and complications such as stent restenosis and advanced thrombosis are effectively inhibited.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and in particular to blood-contact functional materials, their preparation methods and applications. Background technique [0002] Peripheral vascular disease refers to arteriovenous diseases of the extremities, and arterial diseases of the lower extremities are the most common, such as arterial stenosis of the lower extremities, acute embolism of arteries of the lower extremities, venous diseases of the lower extremities are also relatively common, such as varicose veins of the lower extremities, deep vein thrombosis of the lower extremities Form etc. After the peripheral vascular cavity is narrowed, the decrease in blood flow will cause insufficient blood supply to the lower limbs, resulting in limb necrosis and other phenomena. In recent years, the incidence of peripheral vascular disease has increased significantly, which has seriously affected human health. The current treatment metho...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14
CPCA61L31/10A61L31/14C08L79/02C08L87/00
Inventor 黄楠杨作霞钟永英
Owner CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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