Applications of sappan wood in the preparation of anti-PTCA postoperative restenosis and stent restenosis medicaments

A technology of restenosis and sumac, which is applied in the application field of sumac in the preparation of drugs for preventing and treating restenosis after PTCA and in-stent restenosis, can solve the problems that have not yet been reported on the application of sumac, and achieve efficient prevention and treatment Effect

Inactive Publication Date: 2009-09-23
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no report on the application of sumacin in the preparation of anti-PTCA postoperative restenosis and in-stent restenosis drugs.

Method used

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  • Applications of sappan wood in the preparation of anti-PTCA postoperative restenosis and stent restenosis medicaments
  • Applications of sappan wood in the preparation of anti-PTCA postoperative restenosis and stent restenosis medicaments
  • Applications of sappan wood in the preparation of anti-PTCA postoperative restenosis and stent restenosis medicaments

Examples

Experimental program
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Effect test

Embodiment Construction

[0016] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0017] One, the preparation of sumac water extract

[0018] Sappan (purchased from Chongqing Tongjunge Pharmacy and identified by pharmacognosy) was crushed into fine powder, 100g of fine powder was taken, decocted and extracted 3 times, each time for 1 hour, sequentially added water 1000g, 700g and 500g, combined and extracted solution, filtered, and concentrated over low heat to make a solution equivalent to 0.2 g of crude drug per mL, and stored at 4°C.

[0019] 2. Experimental study on anti-PTCA postoperative restenosis and in-stent restenosis of sumac water extract

[0020] In this example, the rat common carotid artery balloon-injured restenosis model was first used to investigate the effect of hematoxylin water extract on postoperative PTCA from multiple aspects such as thrombus formation, blood vessel loss and rupture, vascular ...

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Abstract

The invention discloses applications of sappan wood in the preparation of anti-PTCA postoperative restenosis and stent restenosis medicaments. Experimental research discovers that the sappan wood has obvious effects which are stronger than rapamycin in preventing and treating common carotid artery sacculus injured restenosis of bandicoots and iliac artery sacculus injured restenosis of rabbits, and can be prepared into anti-PTCA postoperative restenosis and stent restenosis medicaments so as to make the most of the whole adjusting advantages of multi-channel, multi-target and multi-link of the Chinese medicines and provide a high-effective, safe and economical solution for preventing and treating PTCA postoperative restenosis and stent restenosis.

Description

technical field [0001] The invention relates to a new application of traditional Chinese medicine, in particular to the application of sumac in the preparation of drugs for preventing and treating restenosis after PTCA and restenosis in stents. Background technique [0002] Coronary heart disease is a heart disease caused by myocardial ischemia, hypoxia or myocardial necrosis caused by organic stenosis or blockage of coronary arteries. Because of its high morbidity and mortality, it seriously endangers human health. [0003] Since Gruenzig et al. first reported percutaneous transluminal coronary angioplasty (PTCA) for interventional treatment of coronary heart disease in 1977, PTCA and related technologies have gradually matured and become one of the main methods for the treatment of coronary heart disease. It has been widely used clinically. application. However, the incidence of restenosis in 3 to 6 months after PTCA is as high as 30% to 50%, which seriously affects the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/10
Inventor 王贵学龙光凌博唐朝君
Owner CHONGQING UNIV
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