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Method for preparing oral prepn. contg. total flavone of kudzu vine nd said oral prepn.

A technology of Pueraria total flavonoids and oral preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve the problem of long treatment period for cardiovascular and cerebrovascular diseases, failure to reflect the synergistic effect of traditional Chinese medicine, and low absolute bioavailability And other issues

Inactive Publication Date: 2004-07-21
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But simultaneously, the shortcoming of these two kinds of preparations is also obvious, one, because the absorption of isoflavones components such as puerarin in gastrointestinal tract is relatively poor, as oral preparations, absolute bioavailability is very low (Yufeng Ningxin tablet is example, less than 6%)
Second, due to the long course of treatment for cardiovascular and cerebrovascular diseases, puerarin injections are made and administered in the form of injections, which brings a lot of inconvenience to patients
In addition, puerarin intravenous distribution half-life t 1 / 2 α, elimination half-life t 1 / 2 β. The average residence time MRT is 10.3min, 74.0min and 1.28h respectively. After 5 hours, the drug concentration in the plasma is already very low. To exert the curative effect, intravenous infusion is needed to maintain the drug dose, which increases to a certain extent patient's pain
In addition, the use of a single active ingredient in medicine does not reflect the characteristics of the synergistic effect of traditional Chinese medicine
At present, there is no public report to solve the absorption problem of Pueraria total flavonoids oral preparations

Method used

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  • Method for preparing oral prepn. contg. total flavone of kudzu vine nd said oral prepn.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment one: Radix Puerariae total flavonoids granules

[0016] 1. Take 2kg of kudzu powder, add 20L of 60% ethanol to infiltrate, then extract by hot reflux for 3 times, 2 hours each time, filter, combine the filtrate, concentrate under reduced pressure until there is no alcohol smell, add water to dilute to 10L, and store at 60°C , stir and add 300mL of 1% clarifying agent B solution, stir once every 30 minutes, after 2 hours, add 300mL of 0.5% clarifying agent A solution in the same way, stir again 60 minutes after the addition, after 2 hours, roughly filter, and then add A high-speed centrifuge is used for liquid-solid separation, and the clarified liquid is taken for later use. Pass the above clarified solution into a macroporous resin column (column diameter 10mm, 4L resin is installed), the total flavonoids of kudzu root will be effectively adsorbed in the resin, first wash with 5-10L water until the effluent is colorless, and then use 15L 50 % ethanol desorp...

Embodiment 2

[0019] Embodiment two: kudzu root total flavonoids tablet

[0020] As described in Example 1, the difference is that the obtained pueraria total flavonoids granules are compressed into tablets containing 100 mg of pueraria total flavonoids per tablet.

Embodiment 3

[0021] Embodiment three: kudzu root total flavonoids capsules

[0022] As described in Example 1, the difference is that the obtained total flavonoids of Pueraria radix granules are packed into hard capsule shells to obtain total flavonoids of Pueraria radiata capsules.

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Abstract

An orally applied medicine of common pueraria flavone for treating coronary heart disease, angina pectoris, the occlusive diseases of vein, artery and retina, etc is prepared from the common pueraria flavone and additive through proportional mixing. Its advantages are high curative effect and low dosage.

Description

technical field [0001] The invention relates to a preparation method of an oral preparation of total flavonoids of pueraria radicis using traditional Chinese medicine pueraria lobata root as a raw material and an oral preparation of total flavonoids of pueraria root. Background technique [0002] Pueraria lobata root can be used to treat coronary heart disease, angina pectoris and other diseases related to cardiovascular and cerebrovascular circulation, as well as retinal artery and vein occlusion, sudden deafness and other diseases. Studies in recent years have shown that the isoflavones (puerarin, daidzein, daidzin, formononetin, genistein, etc.) in kudzu root have weak estrogen-like effects, and can replace synthetic estrogen in the treatment of osteoarthritis. related diseases caused by low estrogen levels in the body, such as osteoporosis and menopausal syndrome, and has the advantage of less toxic and side effects. At present, there are mainly two types of kudzu root ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
Inventor 邱鹰昆王东李旭东陈乃光
Owner YANGTZE RIVER PHARM GRP CO LTD
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