Preparation method and novel application of saponin of radix adenophorae
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of ginsenosides and ginseng, which is applied to the preparation of ginsenosides and the field of action in medicines, can solve the problems of not being listed, difficult to improve the quality of life, obvious liver toxicity and the like
Inactive Publication Date: 2017-08-11
NANJING SHENGDAOYUAN PHARMA CO LTD
View PDF1 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
The status of the three types of targeted drugs in the treatment of PAH is unquestionable, but in general, the drug treatment effect of PAH is unsatisfactory, and many PAH patients still die due to right heart failure; Symptoms, it is difficult to imp
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0016] Example 1 ： Preparation method of ginseng saponins for preventing and treating pulmonary hypertension:
[0017] Take 500g of Nansha ginseng medicinal material, wash and chop, add 50% ethanol and reflux for 3 times, reflux for 2 hours each time, and use 5L of solvent each time, combine the extracts, concentrate under reduced pressure, add water to stir and dilute, add to the treated 1kg HPD100 type macroporous adsorption resin column, wash with water until the collected solution is colorless, then elute with 50% ethanol until it is colorless or very light, combine the 50% ethanol eluents, concentrate and dry, and get Nansha ginseng saponins.
Embodiment 2
[0018] Example 2 ： Effects of ginseng saponins on pulmonary arterial hypertension induced by lobectomy combined with monocrotaline in SD rats
[0020] 2.2 Experimental drugs and equipment: Nansha ginsenoside, monocrotaline (purchased from Sigma), chloral hydrate, urethane, pressure transducer and PowerLab physiological information collection and processing system
[0021] 2.3 Severe PAH model was established by lobectomy combined with monocrotaline (MCT) injection: the rats were weighed, anesthetized by intraperitoneal injection of 12% urethane (8ml / kg), tracheal intubation was performed with a 16G arteriovenous catheter, and Harvard breathing was connected. Machine (tidal volume 2ml; frequency, 80 times / min; PEEP1.0cmH20. The left fourth intercostal space was inserted into the chest, the left lung lobe was ligated and removed, and the rat lung lobe was 1 lobe on the left, 4 lobes on the right, an...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a preparation method of saponin of radix adenophorae as well as an application of the saponin of radix adenophorae, which is prepared in accordance with technical scheme of the invention, in treating medicines for treating pulmonary arterial hypertension and related cardiovascular diseases caused by the pulmonary arterial hypertension. Based upon experimental studies, the saponin of radix adenophorae provided by the invention can take an obvious effect on reducing mean pulmonary arterial pressure (MPAP), right ventricle systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) of the pulmonary arterial hypertension. The saponin of radix adenophorae can be used for preventing and treating one or more diseases of special pulmonary arterial hypertension, heritable pulmonary arterial hypertension, drug and poison related pulmonary arterial hypertension, risk factor or disease related pulmonary arterial hypertension, pulmonary arterial hypertension caused by pulmonary veno-occlusive disease and (or) pulmonarycapillary hemangiomatosis, and neonatal persistent pulmonary arterial hypertension.
Description
technical field [0001] The invention relates to a preparation method and a new application of the saponin of Nansha ginsenoside, in particular to the effect of the saponin of Nansha ginsenoside in the preparation of medicine for treating pulmonary hypertension, which belongs to the field of traditional Chinese medicine. Background technique [0002] Pulmonary arterial hypertension (PAH) is a pathophysiological state characterized by a progressive increase in pulmonary vascular resistance and pulmonary artery pressure. Progressive increase, which in turn causes right ventricular overload, leading to right ventricular hypertrophy, and eventually can cause the patient to die of right heart failure. The diagnostic criteria of hemodynamics are: the average pulmonary artery pressure detected by right heart catheterization is ≥25mmHg at resting state at sea level. [0003] PAH is harmful and has a high mortality rate. The mechanism of PAH production is not yet fully understood. I...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more