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Preparation method and novel application of radix codonopsis extract

A technology of extracts and Codonopsis pilosula, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as expensive, difficult to improve the quality of life, and obvious liver toxicity

Inactive Publication Date: 2017-08-11
NANJING SHENGDAOYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The status of the three types of targeted drugs in the treatment of PAH is unquestionable, but in general, the drug treatment effect of PAH is unsatisfactory, and many PAH patients still die due to right heart failure; Symptoms, it is difficult to improve the quality of life, and PAH targeted therapy drugs are mostly imported drugs, expensive, not included in the basic medical insurance drug list, and liver toxicity is obvious, and long-term combined drug use is a problem that PAH patients must face

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation method of Codonopsis pilosula extract for preventing and treating pulmonary hypertension:

[0018] Take 500g of Codonopsis pilosula, wash, chop, and decoct 3 times with water, each time for 0.5h, each time with 4L of water, combine the decoction liquid, concentrate under reduced pressure, add to the treated 1kg HPD100 macroporous adsorption resin column First, wash with water until the collected liquid is colorless, then elute with 60% ethanol until it is colorless or very light, collect the 60% ethanol eluate, concentrate and dry to obtain Codonopsis pilosula extract.

Embodiment 2

[0019] Example 2: Effects of Codonopsis Codonopsis Extract on Pulmonary Arterial Hypertension in SD Rats Induced by Lobectomy Combined with Monocrotaline

[0020] 2.1. Experimental animals: SD rats, 3 months old, male, 200±20g, 48

[0021] 2.2 Experimental drugs and equipment: Codonopsis pilosula extract, monocrotaline (purchased from Sigma), chloral hydrate, urethane, pressure transducer and PowerLab physiological information collection and processing system

[0022] 2.3 Severe PAH model was established by lobectomy combined with monocrotaline (MCT) injection: the rats were weighed, anesthetized by intraperitoneal injection of 12% urethane (8ml / kg), tracheal intubation was performed with a 16G arteriovenous catheter, and Harvard breathing was connected. Machine (tidal volume 2ml; frequency, 80 times / min; PEEP1.0cmH20. The left fourth intercostal space was inserted into the chest, the left lung lobe was ligated and removed, and the rat lung lobe was 1 lobe on the left, 4 lobes...

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PUM

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Abstract

The invention relates to a preparation method and an application of a radix codonopsis extract. Based upon experimental studies, the radix codonopsis extract prepared by technical scheme of the invention can take an obvious effect on reducing mean pulmonary arterial pressure (MPAP), right ventricle systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) of the pulmonary arterial hypertension. The radix codonopsis extract can be used for preventing and treating one or more diseases of special pulmonary arterial hypertension, heritable pulmonary arterial hypertension, drug and poison related pulmonary arterial hypertension, risk factor or disease related pulmonary arterial hypertension, pulmonary arterial hypertension caused by pulmonary veno-occlusive disease and (or) pulmonarycapillary hemangiomatosis, and neonatal persistent pulmonary arterial hypertension.

Description

technical field [0001] The invention relates to a preparation method and new application of Codonopsis pilosula extract, in particular to the effect of Codonopsis pilosula extract in preparing medicine for treating pulmonary hypertension, which belongs to the field of traditional Chinese medicine. Background technique [0002] Pulmonary arterial hypertension (PAH) is a pathophysiological state characterized by a progressive increase in pulmonary vascular resistance and pulmonary artery pressure. Progressive increase, which in turn causes right ventricular overload, leading to right ventricular hypertrophy, and eventually can cause the patient to die of right heart failure. The diagnostic criteria of hemodynamics are: the average pulmonary artery pressure detected by right heart catheterization is ≥25mmHg at resting state at sea level. [0003] PAH is harmful and has a high mortality rate. The mechanism of PAH production is not yet fully understood. It is currently believed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344A61P11/00A61P9/12
CPCA61K36/344A61K2236/331A61K2236/39A61K2236/51A61K2236/55Y02A50/30
Inventor 不公告发明人
Owner NANJING SHENGDAOYUAN PHARMA CO LTD
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