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Application of platycodin D in preparation of medicines for preventing and treating pulmonary hypertension

A technology of pulmonary arterial hypertension and platycodon saponin, which is applied in the field of medicine and can solve problems such as not listed, expensive, and obvious liver toxicity

Inactive Publication Date: 2016-05-04
NANJING SHENGDAOYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The status of the three types of targeted drugs in the treatment of PAH is unquestionable, but in general, the drug treatment effect of PAH is unsatisfactory, and many PAH patients still die due to right heart failure; Symptoms, it is difficult to improve the quality of life, and PAH targeted therapy drugs are mostly imported drugs, expensive, not included in the basic medical insurance drug list, and liver toxicity is obvious, and long-term combined drug use is a problem that PAH patients must face

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Effect of platycodon saponin D on pulmonary arterial pressure hypertension in SD rats induced by lobectomy combined with monocrotaline

[0019] 1.1. Experimental animals: SD rats, 3 months old, male, 200±20g, 48.

[0020] 1.2 Experimental drugs and equipment: platycodon saponin D, monocrotaline (purchased from Sigma), chloral hydrate, urethane, pressure transducer and PowerLab physiological information collection and processing system.

[0021] 1.3 Severe PAH model was established by lobectomy combined with monocrotaline (MCT) injection: the rats were weighed, anesthetized by intraperitoneal injection of 12% urethane (8ml / kg), tracheal intubation was performed with a 16G arteriovenous indwelling needle, and a Harvard respiratory system was connected. Machine (tidal volume 2ml; frequency, 80 times / min; PEEP1.0cmH20. The left fourth intercostal space was inserted into the chest, the left lung lobe was ligated and removed, and the rat lung lobe was 1 lobe on the...

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PUM

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Abstract

The invention relates to application of platycodin D in preparation of medicines for preventing and treating pulmonary hypertension. According to the technical scheme, platycodin D and compositions containing platycodin D are used for treating pulmonary hypertension and cardiovascular related diseases caused by pulmonary hypertension. Experimental researches discover that platycodin D can be used for preventing and treating arbitrary one or more of idiopathic pulmonary hypertension, heritable pulmonary arterial hypertension, drug and toxin related pulmonary hypertension, hazard factor or disease related pulmonary hypertension, pulmonary hypertension caused by pulmonary veno-occlusive disease and (or) pulmonary capillary hemangiomatosis-like diseases, and persistent pulmonary hypertension of newborn.

Description

technical field [0001] The invention relates to a new application of platycodon saponin D, in particular to the application of platycodon saponin D in the preparation of medicines for treating pulmonary hypertension, which belongs to the field of medicine. Background technique [0002] Pulmonary arterial hypertension (PAH) is a pathophysiological state characterized by a progressive increase in pulmonary vascular resistance and pulmonary artery pressure. Elevated, which in turn causes right ventricular overload, leading to right ventricular hypertrophy, and ultimately can cause patients to die of right heart failure. The diagnostic criteria of hemodynamics are: the average pulmonary artery pressure detected by right heart catheterization is ≥25mmHg at resting state at sea level. [0003] PAH is harmful and has a high mortality rate. At present, there are mainly three types of targeted therapy drugs for PAH, including prostacyclin analogs, endothelin receptor antagonists (e...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/12A61P9/00
CPCA61K31/704Y02A50/30
Inventor 不公告发明人
Owner NANJING SHENGDAOYUAN PHARMA CO LTD
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