Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of treatment of cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases takes yang warming and body resistance strengthening as a core, is added with insect medicines for dredging collaterals and is combined with traditional Chinese medicines for promoting blood circulation to remove blood stasis; a traditional Chinese medicine composition mainly comprising pilose antler, wild ginseng under forest, centipede, Yunnan poecilobdella manillensis and the like is created and prepared into water-honeyed pills to be taken; after clinical application, the water-honeyed pills have obvious curative effects on patients suffering from coronary atherosclerotic cardiovascular and cerebrovascular diseases, including patients with poor western medicine treatment effects, and meanwhile, high-risk factors such as hypertension, hyperglycemia and hyperlipidemia of the patients are effectively corrected; the traditional Chinese medicine composition is used for treating metabolic syndrome, systemic atherosclerosis, deficiency arrhythmia and cardiovascular and cerebrovascular diseases in the early stage and the recovery stage, and the symptoms of the cardiovascular and cerebrovascular diseases can be improved after the traditional Chinese medicine composition is taken for at least three weeks.

Description

Technical Field

[0001] The present invention belongs to the technical field of cardiovascular and cerebrovascular disease treatment, and in particular, relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background Art

[0002] As the body ages, coupled with the effects of years of bad habits and a tiring lifestyle, it can lead to a variety of illnesses. Traditional Chinese medicine calls this "conjunctivitis," or "pulsation," affecting all large and small arteries throughout the body, particularly those of the heart and brain. This condition, known as "pulsation," affects arteries throughout the body, particularly those of the heart and brain. Pulsation (also known as atherosclerotic cardiovascular and cerebrovascular disease) is the leading disease among middle-aged and elderly people. Cardiovascular and cerebrovascular disease is fundamentally caused by the weakness of the five internal organs, with blood stasis and vascular blockage merely secondary manifestations. Activating blood circulation and removing blood stasis are primarily symptomatic treatments. Cardiovascular and cerebrovascular disease should be addressed both symptomatically and fundamentally, with emphasis placed on strengthening the vital energy and utilizing tonification as the fundamental approach. From the perspective of treating deficiency syndromes, tonification is the primary approach, supplemented by removing blood stasis. Tonifying treatment promotes neuro-endocrine function, improves metabolism, solves glucose and lipid metabolism disorders, eliminates chronic inflammatory damage to the body and blood vessels, and promotes the regeneration and functional recovery of the myocardial and nerve cells. Blood stasis treatment focuses on solving the stenosis and embolism of large blood vessels and small blood vessel lesions including microcirculation disorders. The rapid recovery of microcirculation provides a guarantee for the repair of the myocardium and nerves and reduces inflammatory re-injury, thereby fundamentally changing the occurrence and progression of cardiovascular and cerebrovascular diseases.

[0003] According to Traditional Chinese Medicine, the root cause of cardiovascular and cerebrovascular diseases lies in the deficiency of the five internal organs, especially the heart, spleen, and kidneys. This leads to insufficient Qi and blood, which are unable to nourish the meridians, and then cause pathological changes such as blood stasis and embolism. Therefore, the principle of traditional Chinese medicine in treating cardiovascular diseases is to "tonify the deficiency and strengthen the foundation." That is, by nourishing the heart, spleen, and kidneys, restoring the function of the internal organs, and ensuring sufficient Qi and blood biochemical production, it improves cardiovascular and cerebrovascular function from the source. The core pathology of atherosclerosis is vascular stenosis and thrombosis, which lead to blood flow obstruction and subsequently cause critical illnesses such as myocardial infarction and stroke. Unblocking the meridians and promoting blood circulation is an important strategy for treating cardiovascular and cerebrovascular diseases. Metabolic syndrome, such as hyperlipidemia, hyperglycemia, and hypertension, is one of the key factors leading to arteriosclerosis. Long-term abnormal glucose and lipid metabolism will accelerate vascular aging, damage the vascular endothelium, trigger an inflammatory response, and ultimately lead to cardiovascular and cerebrovascular diseases. Traditional Chinese medicine also takes into account the role of improving metabolic function during treatment.

[0004] Cardiovascular and cerebrovascular diseases are not sudden onset diseases, but rather the result of long-term accumulation. Therefore, prevention and conditioning are crucial. Traditional Chinese medicine treatment can not only treat patients who have already developed the disease, but also has a strong health-preserving effect. Summary of the Invention

[0005] In order to overcome the problems existing in the background technology, the present invention discloses a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases takes warming yang and strengthening the body as the core, adds insect drugs for unblocking meridians, and combines traditional Chinese medicines for promoting blood circulation and removing blood stasis. The traditional Chinese medicine composition is mainly composed of high-quality deer antler, wild ginseng, centipede, Yunnan leech, etc. The traditional Chinese medicine composition is prepared into water-honeyed pills for oral administration. After clinical application, it was found that the water-honeyed pills have obvious therapeutic effects on patients with coronary atherosclerotic cardiovascular and cerebrovascular diseases, including patients with poor results of Western medicine treatment, and effectively correct the patients' high-risk factors such as hypertension, hyperglycemia, and hyperlipidemia. This traditional Chinese medicine composition is used for the treatment of metabolic syndrome, systemic atherosclerosis, asthenic arrhythmia, and the early and recovery stages of cardiovascular and cerebrovascular diseases. After taking the medicine for at least 3 weeks, the symptoms of the above-mentioned cardiovascular and cerebrovascular diseases can be improved.

[0006] To achieve the above object, the present invention is implemented through the following technical solutions: The traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases is characterized in that the prescription of the composition includes: 7-120 grams of deer antler, 5-130 grams of placenta, 2-60 grams of scorpion, 2-40 grams of centipede, 4-100 grams of ginseng, 8-120 grams of coptis chinensis, 8-140 grams of black plum meat, 2-60 grams of amber, 11-180 grams of leech, 8-140 grams of earthworm, 4-120 grams of Panax notoginseng, 8-120 grams of cinnamon, 2-40 grams of red ochre, 1-30 grams of frankincense, 10-350 grams of cooked aconite root, 2-50 grams of Ganoderma lucidum spore powder, and 1-10 grams of borneol.

[0007] Preferably, the composition prescription is: 100 grams of deer antler, 100 grams of placenta, 40 grams of scorpion, 20 centipedes, 80 grams of ginseng, 80 grams of coptis chinensis, 80 grams of black plum meat, 40 grams of amber, 140 grams of leech, 80 grams of earthworm, 80 grams of Panax notoginseng, 80 grams of cinnamon, 20 grams of red ochre, 20 grams of frankincense, 300 grams of roasted aconite root, 20 grams of Ganoderma lucidum spore powder, and 3 grams of borneol.

[0008] Preferably, the method for preparing the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following steps: (1) Prescription: Prescribe Chinese medicinal materials according to the dosage, and check the dosage after collection; Ganoderma lucidum spore powder and borneol in the prescription should be collected and placed separately, and the remaining medicinal materials should be collected and mixed; (2) Soaking the herbs: grab the remaining herbs and add tea seed extract to soak for 10 to 30 minutes. After soaking, remove and dry. (3) Mixing medicine: The remaining medicinal materials after drying are crushed into medicinal material powder, and the medicinal material powder is mixed with Ganoderma lucidum spore powder and borneol to obtain a mixture, and the mixture is steamed for 25 to 45 minutes; (4) Boiling the medicine: Add honey and water to the steamed mixture and boil until it becomes viscous and no Chinese medicine powder is visible to the naked eye. Cool it to obtain the soft medicine material; (5) Refining: The soft medicinal materials are processed to obtain medicinal lumps; (6) Pill making: The drug mass is mixed with the lubricant and then added to the pill making machine for pill making.

[0009] Preferably, in step (3), the borneol is ball-milled into borneol fine powder and then mixed with the medicinal material fine powder and Ganoderma lucidum spore powder.

[0010] Preferably, in step (4), the amount of honey added is 30% to 50% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol powder, and the amount of water added is 5% to 20% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol powder.

[0011] As a preference: in the step (5), the medicine refining operation is to add the medicine soft material into the pill refining machine for the medicine refining operation, and the medicine refining operation is repeated 2 to 4 times.

[0012] Preferably, in step (6), the lubricant is pill oil, which is prepared by heating sesame oil to boiling and then adding clean beeswax; adding 120 grams of wax to every 500 grams of oil, filtering impurities after melting, and cooling for later use.

[0013] As a preference: the pills prepared in step (6) are water-honeyed pills, which are packaged at 11 g / bag.

[0014] As a preferred method, the water-honeyed pills are taken orally half an hour after a meal, three times a day, one bag at a time. No western medicine should be taken and no fruit should be eaten within one hour after taking the pills.

[0015] Preferably, the water-honeyed pills are taken for four months as a course of treatment.

[0016] The beneficial effects of the present invention are as follows: the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases takes warming yang and strengthening the body as the core, adds insect medicines for unblocking meridians, and combines traditional Chinese medicines for promoting blood circulation and removing blood stasis to create a prescription for nourishing deficiency and clearing meridians mainly composed of high-quality deer antler, wild ginseng, centipede, Yunnan leech, etc. The traditional Chinese medicine composition is prepared into water-honeyed pills for oral administration; after clinical application, it is found that the water-honeyed pills have obvious therapeutic effects on patients with coronary atherosclerotic cardiovascular and cerebrovascular diseases, including patients with poor results of Western medicine treatment, and effectively correct the patients' high-risk factors such as hypertension, hyperglycemia, and hyperlipidemia. This traditional Chinese medicine composition is used for the treatment of metabolic syndrome, systemic atherosclerosis, asthenic arrhythmia, and the early and recovery stages of cardiovascular and cerebrovascular diseases. After taking the medicine for at least 3 weeks, the symptoms of the above-mentioned cardiovascular and cerebrovascular diseases can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is the carotid artery ultrasound examination image of Case 1 before medication treatment; Figure 2This is the carotid artery ultrasound examination image of Case 1 after taking medication; DETAILED DESCRIPTION

[0018] In order to make the above-mentioned objectives, technical solutions and beneficial effects clearer and more specific, the present invention is described in detail below with reference to embodiments.

[0019] Example 1: (1) According to the prescribed dosage: 7g of deer antler, 5g of placenta, 2g of scorpion, 2g of centipede, 4g of ginseng, 8g of coptis root, 8g of black plum meat, 2g of amber, 11g of leech, 8g of earthworm, 4g of notoginseng, 8g of cinnamon bark, 2g of red ochre, 1g of frankincense, 10g of roasted aconite root, 2g of ganoderma lucidum spore powder, 1g of borneol, pick out the Chinese medicine, and check the dosage after picking up the Chinese medicine. (2) When dispensing the medicine, the Ganoderma lucidum spore powder and borneol in the prescription are dispensed separately, and the remaining medicines are dispensed together and then ground into powder, which is then mixed with the Ganoderma lucidum spore powder and borneol to obtain a mixture; (4) Steam the mixture for 30 minutes, add honey and water (mix and boil until it becomes viscous and no Chinese medicine powder is visible to the naked eye), and then make pills; (5) Pill making operation: use a pill making machine to make pills.

[0020] Example 2: (1) According to the prescribed dosage: 120g of deer antler, 130g of placenta, 60g of scorpion, 40g of centipede, 100g of ginseng, 120g of coptis root, 140g of black plum meat, 60g of amber, 180g of leech, 140g of earthworm, 120g of notoginseng, 120g of cinnamon bark, 40g of red ochre, 30g of frankincense, 350g of roasted aconite root, 50g of ganoderma lucidum spore powder, 10g of borneol, pick out the Chinese medicine, and check the dosage after picking up the Chinese medicine; (2) When dispensing the medicine, the Ganoderma lucidum spore powder and borneol in the prescription are dispensed separately, and the remaining medicines are dispensed together and then ground into powder, which is then mixed with the Ganoderma lucidum spore powder and borneol to obtain a mixture; (4) Steam the mixture for 30 minutes, add honey and water, and boil until it becomes viscous and no Chinese medicine powder is visible to the naked eye, then make pills; (5) Pill making operation: use a pill making machine to make pills.

[0021] Example 3: (1) According to the prescribed dosage: 100g of deer antler, 100g of placenta, 40g of scorpion, 20 centipedes, 80g of ginseng, 80g of coptis root, 80g of black plum meat, 40g of amber, 140g of leech, 80g of earthworm, 80g of Panax notoginseng, 80g of cinnamon bark, 20g of red ochre, 20g of frankincense, 300g of roasted aconite root, 20g of ganoderma lucidum spore powder, 3g of borneol, pick out the Chinese medicine, and check the dosage after picking up the Chinese medicine; pick out the ganoderma lucidum spore powder and borneol in the prescription and place them separately, and pick out the remaining medicinal materials and mix them together; (2) Soaking the herbs: grab the remaining herbs and add tea seed extract to soak for 30 minutes. After soaking, remove and dry. (3) Mixing medicine: The remaining medicinal materials after drying are crushed into medicinal material powder, and the medicinal material powder is mixed with Ganoderma lucidum spore powder and borneol to obtain a mixture. The borneol is ball-milled into borneol powder, and then mixed with the medicinal material powder and Ganoderma lucidum spore powder. The mixture is steamed for 30 minutes; (4) Boiling the medicine: add honey and water to the steamed mixture and boil until it becomes viscous and no Chinese medicine powder is visible to the naked eye. Cool it to obtain a soft medicine material. The amount of honey added is 40% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol fine powder. The amount of water added is 15% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol fine powder. (5) Refining: The soft medicinal materials are processed to obtain medicinal lumps. The refining operation is to add the soft medicinal materials to the pill refining machine for refining. The refining operation is repeated 3 times. (6) Pill making: The lubricant is pill oil. The preparation of pill oil is to heat sesame oil to boiling and then add clean beeswax; add 120 grams of wax to every 500 grams of oil, filter impurities after melting, and let it cool for use; the drug mass is mixed with the lubricant and added to the pill making machine for pill making; the pills are water-honey pills, and the water-tight pills are packaged at 11 grams per bag.

[0022] Treatment Cases: The treatment was carried out using the technical solution described in Example 3. The method of taking the water-honeyed pills was to take them orally half an hour after a meal, three times a day, one bag at a time. No western medicine or fruit should be taken within one hour after taking the medicine. A course of treatment for the water-honeyed pills was four months.

[0023] Case 1: Zhou, a 49-year-old male, presented to the hospital in 2020 with chest tightness and pain that had persisted for five years. He had a history of hypertension and was initially diagnosed with coronary atherosclerotic heart disease (CAD). Over the past five years, he had experienced frequent chest tightness after activity, accompanied by stabbing pain in the precordial area. The pain often flared up after exertion or emotional excitement and was relieved by rest. A coronary angiogram performed one month prior revealed 90% stenosis of the left anterior descending coronary artery. The patient declined stent placement and requested Traditional Chinese Medicine (TCM) treatment. A sallow complexion, a weak, thready pulse, a pale tongue, and a thin, white fur with cracks were all present. TCM diagnosed the patient with chest pain and a fatigued pulse. Treatment with a Buxu Qingmai formula resolved the chest tightness and pain within three weeks, and his mental state significantly improved. A year later, his blood pressure returned to normal, and a repeat coronary angiogram revealed significant improvement in the stenosis of the left anterior descending coronary artery, now only 30%. The patient has been under observation for fifteen years and is leading a normal life.

[0024] Case 2: Wu, a 68-year-old male, presented to the hospital in May 2016 with chest tightness, palpitations, and fatigue that had lasted for three years. An electrocardiogram (ECG) revealed a heart rate of 46 beats / min with irregular heart rhythms. Ultrasound scans of both carotid and femoral arteries revealed numerous unstable plaques. Western medicine diagnosed him with coronary atherosclerotic heart disease and sick sinus syndrome. Traditional Chinese medicine (TCM) diagnostics revealed a pale-gray complexion, a deep, knotted, weak, and delayed pulse, and a blue tongue. The TCM diagnosis was chest pain and a weak pulse. He was treated with Bu Shui Mi Wan pills. The chest tightness resolved after one month, his physical strength and spirits returned to normal, and his complexion became rosy. Six months later, his heart rate increased to 65 beats / min with a regular rhythm. Ultrasound scans revealed a significant reduction in the plaques, indicating stable plaques.

[0025] Case 3: Mr. Luo, a 73-year-old male, sought medical attention in May 2005 because he was still unable to work hard three years after coronary stent implantation. He had a history of hypertension and hyperlipidemia. Three stents were placed for coronary artery stenosis, but he still experienced chest tightness and discomfort after the surgery. He had to stop and rest after walking 100 meters on flat ground or climbing one flight of stairs. Ultrasound showed unstable plaques in the right carotid artery and bilateral femoral arteries. Senile pigmentation was seen on the face and backs of his hands, his pulse was deep, thin, and weak, and his tongue was pale with cracks. Traditional Chinese Medicine diagnosed him with chest pain and pulse fatigue. He was treated with Bu Shui Mi Wan three times a day. The chest tightness disappeared after two months, and his walking ability returned to normal. He died of this disease 12 years later.

[0026] Case 4: Mr. He, a 69-year-old male, presented to our clinic in July 2017 with dizziness, insomnia, and memory loss for five years. He had a 10-year history of hypertension and diabetes, and a cerebral infarction three years prior. Ultrasound revealed unstable plaques in both carotid arteries. His pulse was weak and stringy, and his tongue was thick and pale with a greasy white coating. Traditional Chinese Medicine diagnosed him with pulse fatigue. After two months of treatment with Bu Shui Mi Wan, his insomnia improved, and six months later, his thinking and reaction time improved. He reported that he was able to make winning hands faster when playing mahjong.

[0027] Case 5: Wu, a 47-year-old male, presented to the hospital in November 2018 with six months of heart palpitations. He had experienced paroxysmal palpitations, insomnia, and anxiety. Ultrasound examination revealed unstable plaques in both carotid arteries. His tongue was pale, and his pulse was deep, stringy, and knotted. Traditional Chinese Medicine diagnosed him with palpitations and a weak pulse. He was treated with Bu Shui Mi Wan (Bu Shui Mi Wan) for one day, and his palpitations disappeared. Within two weeks, his insomnia and anxiety improved. One year later, ultrasound examination revealed stable carotid plaques.

[0028] The comparison of the treatment effects is shown in the following table: From the above treatment cases, it can be seen that the Shuimi pills prepared from the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases have obvious therapeutic effects on patients with coronary atherosclerotic heart disease. After taking the medicine for at least 3 weeks, the symptoms of the above cardiovascular and cerebrovascular diseases can be improved.

[0029] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not limiting. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, characterized in that: The composition prescription includes: 7-120 grams of deer antler, 5-130 grams of placenta, 2-60 grams of scorpion, 2-40 grams of centipede, 4-100 grams of ginseng, 8-120 grams of coptis chinensis, 8-140 grams of black plum meat, 2-60 grams of amber, 11-180 grams of leech, 8-140 grams of earthworm, 4-120 grams of Panax notoginseng, 8-120 grams of cinnamon, 2-40 grams of red ochre, 1-30 grams of frankincense, 10-350 grams of cooked aconite root, 2-50 grams of Ganoderma lucidum spore powder, and 1-10 grams of borneol.

2. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The composition prescription is preferably: 100 grams of deer antler, 100 grams of placenta, 40 grams of scorpion, 20 grams of centipede, 80 grams of ginseng, 80 grams of coptis chinensis, 80 grams of black plum meat, 40 grams of amber, 140 grams of leech, 80 grams of earthworm, 80 grams of Panax notoginseng, 80 grams of cinnamon, 20 grams of red ochre, 20 grams of frankincense, 300 grams of roasted aconite root, 20 grams of Ganoderma lucidum spore powder, and 3 grams of borneol.

3. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following steps: (1) Prescription: Prescribe Chinese medicinal materials according to the dosage, and check the dosage after collection; Ganoderma lucidum spore powder and borneol in the prescription should be collected and placed separately, and the remaining medicinal materials should be collected and placed together; (2) Soaking the herbs: grab the remaining herbs and add tea seed extract to soak for 10 to 30 minutes. After soaking, remove and dry. (3) Mixing medicine: The remaining medicinal materials after drying are crushed into medicinal material powder, and the medicinal material powder is mixed with Ganoderma lucidum spore powder and borneol to obtain a mixture, and the mixture is steamed for 25 to 45 minutes; (4) Boiling the medicine: Add honey and water to the steamed mixture and boil until it becomes viscous and no Chinese medicine powder is visible to the naked eye. Cool it to obtain the soft medicine material; (5) Refining medicine: The soft medicinal materials are processed to obtain medicinal lumps; (6) Pill making: The drug mass is mixed with the lubricant and then added to the pill making machine for pill making.

4. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: In the step (3), the borneol is ball-milled into borneol fine powder and then mixed with the medicinal material fine powder and Ganoderma lucidum spore powder.

5. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: In step (4), the amount of honey added is 30% to 50% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol powder, and the amount of water added is 5% to 20% of the total mass of the medicinal material powder, Ganoderma lucidum spore powder, and borneol powder.

6. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: In the step (5), the medicine refining operation is to add the medicine soft material into the pill refining machine to perform the medicine refining operation, and the medicine refining operation is repeated 2 to 4 times.

7. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: In step (6), the lubricant is pill oil, which is prepared by heating sesame oil to boiling and then adding clean beeswax; 120 grams of beeswax is added to every 500 grams of oil, and after melting, impurities are filtered out and the oil is cooled for later use.

8. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: The pills prepared in step (6) are water-honeyed pills, and the water-tight pills are packaged at 11 grams per bag.

9. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 8, characterized in that: The method for taking the water-honeyed pill is to take it orally half an hour after a meal, three times a day, one bag at a time. No western medicine should be taken and no fruit should be eaten within one hour after taking the pill.

10. A Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 9, characterized in that: The water-honeyed pills are taken for four months as a course of treatment.

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