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258 results about "Diacyl glycerol" patented technology
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Diacylglycerol is found in small amounts in plant oils. In its concentrated form, it is used to replace fats in the diet. Diacylglycerol is used to promote weight loss and to treat high levels of certain blood fats called triglycerides. In manufacturing, diacylglycerol is used as a stabilizer, thickener, and texturizer.
Diacylglycerol o-acyltransferase
InactiveUS6344548B1Sugar derivativesPeptide/protein ingredientsDiglyceride acyltransferase activityTriacylglycerol VLDL
Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
Owner:VETERANS AFFAIRS DEPT OF +3
Modulation of diacylglycerol acyltransferase 2 expression
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
Owner:IONIS PHARMA INC
Self forming, thermodynamically stable liposomes and their applications
InactiveUS6958160B1Ultrasonic/sonic/infrasonic diagnosticsOrganic active ingredientsSelf formingLipid composition
A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is below about 40 degrees C., and the acyl chains of the diacylglycerol-PEG are greater than or equal to 14 carbons in length. Such liposome suspensions are useful for a variety of purposes, including the delivery of therapeutic agents.
Owner:BIOZONE LAB
Oil or fat composition
InactiveUS6844021B2Specific degree of stabilityReduction of body fat and visceral fatBiocideEdible oils/fats ingredientsDiseaseTherapeutic effect
The oil or fat composition of the invention contains a monoacylglycerol and / or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and / or the diacylglycerol contain, as fatty acid constituents, ω3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil / fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.
Owner:KAO CORP
Plant diacylglycerol O-acyltransferase and uses thereof
Plant nucleic acid compositions encoding polypeptide products with diacylglyceride acyltransferase (DGAT) activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. Methods and compositions for modulating DGAT activity in a plant, particularly DGAT activity in plant seeds, and transgenic plants with altered DGAT activity are provided. Such plants and seeds are useful in the production of human food and animal feedstuff, and have several other industrial applications. Also provided are methods for making triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry.
Owner:RGT UNIV OF CALIFORNIA
Diacylglycerol acyltransferase gene from plants
InactiveUS7015373B1Reduced DGAT activityReduce rateSugar derivativesTransferasesBrassicaceaePlanting seed
Owner:NAT RES COUNCIL OF CANADA
Process for non-catalytically producing biodiesel fuel without yielding by-product
InactiveUS20060288636A1Fatty oils/acids recovery from wasteFatty acid esterificationReaction temperatureFatty acid methyl ester
This invention provides a process for producing biodiesel fuel from vegetable or animal oils and fats or wastes thereof and methanol that does not use a catalyst and does not generate glycerin as a by-product. In this process, vegetable or animal oils and fats or wastes thereof are mixed with methanol, and a methanolysis reaction is carried out at a reaction temperature of between 370° C. and 500° C., a reaction pressure of between 20 MPa and 60 MPa, and a reaction period of between 4 minutes and 12 minutes without the use of a catalyst. This invention also provides biodiesel fuel that is mainly composed of fatty acid methyl esters, monoacylglycerol, and diacylglycerol.
Owner:INC ADMINISTRATIVE AGENCY NAT AGRI & BIO ORIENTED RES ORG
Use of the cathelicidin LL-37 and derivatives thereof for wound healing
ActiveUS7452864B2Promote regenerationWound be enhancedAntibacterial agentsPeptide/protein ingredientsCytotoxicityCell culture media
Use of the antimicrobial cathelicidin peptide ll-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithalial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
Owner:PROMORE PHARMA AB
Partial acyl glyceride based biowaxes, biocandles prepared therefrom and their preparation
InactiveUS20080145808A1Promote healthy developmentImprove featuresSolid fuelsCapillary burnersWaxMedicine
The present invention relates to a biowax comprising a partial acyl glyceride selected from the group consisting of a monoacylglyceride, a diacylglyceride and the combination thereof. The present invention also relates to a biocandle comprising a biowax and a wick, and to a method of producing the same.
Owner:CHANT OIL
Diacylglycerol acyl transferase proteins
InactiveUS7135617B2Increase percentageIncreased DAGAT activitySugar derivativesPeptide/protein ingredientsDiseaseMortierella ramanniana
The invention provides diacylglycerol acyltransferase (DAGAT) proteins, wherein said proteins are active in the formation of triacylglycerol from fatty acyl and diacylglycerol substrates. In one aspect, Mortierella ramanniana DAGAT proteins have been isolated and have molecular weights of between approximately 36 and 37 kDa as measured by SDS-PAGE. The invention also provides novel DAGAT polynucleotide and polypeptide sequences and to methods of producing such polypeptides using recombinannt techniques. In addition, methods are provided for using such sequences to alter triacylglycerol levels in plants and to treat diseases associated with altered DAGAT activity or expression.
Owner:MONSANTO TECH LLC
Diacylglycerol acyltransferase 2 inhibitors
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
Owner:PFIZER INC
Weight management system for animals
InactiveUS20030138547A1Organic active ingredientsInorganic non-active ingredientsBiotechnologyAdditive ingredient
A pet food product for promoting comprehensive weight management in companion animals. The pet food includes, on a dry matter basis, about 35 to about 70% by weight of a protein, about 4 to about 10% by weight of a fat, about 5 to about 25% by weight of a fiber, about 10 to about 35% by weight of a digestible carbohydrate, and about 0.1 to about 1% by weight of a functional ingredient. In a preferred embodiment a diacylglyceride is the functional ingredient.
Owner:MARS INC
Regulatory Factors Controlling Oil Biosynthesis In Microalgae And Their Use
The production of transgenic plant oils is described by transfecting plant host cells with heterologous transcription inducers. Such inducers are specific for endogenous biosynthetic plant oil genes, such that the inducers induce an overexpression of the plant oil genes. The overexpressed gene product (i.e., for example, diacylglycerol transferase) thereby results in a increased intracellular production of a plant oil (i.e., for example, triacylglycerol). In one embodiment, the transfected plant host cell can be a plant algae species (i.e., for example, Chlamydomonas reinhardtii).
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIV
Diacylglycerol acyl transferase proteins
The invention provides diacylglycerol acyltransferase (DAGAT) proteins, wherein said proteins are active in the formation of triacylglycerol from fatty acyl and diacylglycerol substrates. In one aspect, Mortierella ramanniana DAGAT proteins have been isolated and have molecular weights of between approximately 36 and 37 kDa as measured by SDS-PAGE. The invention also provides novel DAGAT polynucleotide and polypeptide sequences and to methods of producing such polypeptides using recombinant techniques. In addition, methods are provided for using such sequences to alter triacylglycerol levels in plants and to treat diseases associated with altered DAGAT activity or expression.
Owner:MONSANTO TECH LLC
Pet foods
InactiveUS20090148560A1Improving pet ' appearanceHigh purityMilk preparationFatty substance preservation using additivesSorghumCompanion animal
A pet food containing (A) an oil or fat and (B) one or more carbohydrate sources selected from the group consisting of modified starch, barley, sorghum, corn and high-amylose starch, wherein a content of diacylglycerol in the whole oil or fat is 20 wt % or higher.The pet food according to the present invention is excellent in the preventing or controlling effect on obesity, is not reduced in ingestion capacity, and does not affect stool conditions.
Owner:KAO CORP
Fractionation of phytosterol esters in oil
A composition of at least one diacylglycerol and at least one phytosterol and / or phytostanol ester dissolved or dispersed in an edible oil and / or edible fat, and further optionally containing monoglycerides. Phytosterol esters may be beta-sitosterol, campesterol, stigmasterol and brassicasterol esters. Phytostanol esters may be stigmasterol, campestanol and sitostanol. The phytosterol and / or phytostanol esters are preferably esters of C14-C22, preferably C16-C18 saturated or unsaturated fatty acids, particularly oleic, linoleic, linolenic, palmitic and stearic acids. The diacylglycerol(s) are preferably 1,3-di-fatty acyl glycerol(s). A process for preparing compositions enriched with triacylglycerol(s) and phytosterol and / or phytostanol esters of mainly unsaturated fatty acid(s) or of mainly saturated fatty acid(s). Dietary food supplements and alimentary products derived from the above compositions.
Owner:ENZYMOTEC
Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
Owner:ABBOTT LAB INC
Immunomodulating Agent, Anti-Cancer Agent and Health Food Containing Monoacetyldiacylglycerol Derivatives
The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against cancer cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a health food for an immune modulation or the prevention of cancer.
Owner:ENZYCHEM LIFESCI CORP
Nutritional composition and a container for the convenient transport and storage of the nutritional composition
InactiveUS20060193961A1Minimize oxidation of fatty acidAvoid contactFood ingredientsFood preparationOctadecadienoic AcidLipid oxidation
The present invention relates to a combination of a hermetically sealed, substantially air-tight container and a nutritional composition. The container of the present invention is adapted for the convenient transport, and storage of a single daily oral dose of a nutritional composition containing a fatty acid, for example, diacyl glycerol, an octadecatrienoic acid, an octadecadienoic acid, linolenic acid, linoleic acid, conjugated linoleic acid (CLA) or a combination thereof. In a preferred embodiment, the present invention relates to the use of the c9, t11 and t10, c12 isomers of CLA in a nutritional composition. The wide range of health benefits associated with consumption of these CLA fatty acids is well known. Furthermore, the invention relates to a container that substantially prevents CLA lipid oxidation caused by exposure to air.
Owner:SHASTRI SIDDHARTH +1
Acyltransferase
InactiveUS7498026B2Fatty acid esters) is increasedEasy to calculateSugar derivativesPeptide/protein ingredientsNucleotideNucleotide sequencing
Owner:GENENCOR INT INC
Process for producing fat or oil
ActiveUS20060258872A1Fatty oils/acids recovery from wasteOrganic compound preparationDistillationAcylal
A method for producing a diacylglycerol-rich fat or oil is provided. This method includes the steps of reacting an acyl group donor with an acyl group receptor, and separating unreacted material and byproducts by distillation for use as a part of the starting material in the subsequent cycle of production. The distillation is conducted such that the content of monoacylglycerol in the fat or oil after the distillation is 0.5 to 15% by weight.
Owner:KAO CORP
Diacylglycerol acyltransferase (DGAT) assay
InactiveUS20020127627A1Reduce eliminate activityUseful biological activityCompound screeningApoptosis detectionAcetyltransferaseDrug biological activity
The present invention provides a method for measuring diacylglycerol acetyltransferase (DGAT) activity which utilizes a novel solvent system to reduce and / or eliminate the activities of related compounds. The present invention also discloses a method for determining whether a compound is useful for modulating DGAT biological activity. The method is capable of being utilized for mass screening of compounds as modulators of the biological activity of DGAT.
Owner:WARNER-LAMBERT CO
Monoacetyldiacylglycerol derivative for the treatment of sepsis
The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against cancer cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a health food for an immune modulation or the prevention of cancer.
Owner:ENZYCHEM LIFESCI CORP
Composition containing herbal medicine component for promoting absorption and production method thereof
To make diacylglycerol obtained by adding an emulsifier contain both an effective oil-soluble component and an effective water-soluble component which are contained in herbal medicines, a herbal medicine component for promoting the absorption of the oil-soluble component in the small intestine and a production method thereof are objects of the present invention. The powder of the herbal medicines is added to solvent oil selected from diacylglycerol and / or triacylglycerol cooking oil to which lecithin and / or a W / O type emulsifier are added, is heated and an herbal medicine component is extracted or dissolved. By such a method, drugs and healthy food which contain all effective oil-soluble and water-soluble components contained in the herbal medicines and which promote the absorption of the oil-soluble components in the small intestine can be produced.
Owner:OSHIRO SEIRI
Oil or Fat Composition
InactiveUS20080069932A1Great tasteImpairment in external appearanceFatty acid chemical modificationFatty acids production/refiningPlant sterolOil and grease
Provided is an oil or fat composition of high diacylglycerol content. Even when used in cooking, the cooked food has a good external appearance without darkening, and retains its inherent flavor. Even when used in cooking after storage under light-exposed conditions, the cooked food is provided with a good external appearance and flavor. The oil or fat composition is obtained by combining, at specific contents, (A) an oil or fat of high diacylglycerol content, said oil or fat having a particular composition, (B) a plant sterol and (C) a plant sterol fatty acid ester.
Owner:KAO CORP
Diacylglycerol acyl transferase 2 inhibitors
ActiveUS10071992B2Lower capability requirementsPowder deliveryOrganic active ingredientsDiseaseBiochemistry
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
Owner:PFIZER INC
Edible grease composition
InactiveCN1628546AImprove performanceEdible oils/fats ingredientsCream substitutesOil and greaseStearic acid
The objective of the present invention is to obtain an oil and fat composition attaining at high level flavor, foaming properties, water holding ability, melting feeling in the mouth and appearance at the time of preservation, and suitable for shortening and margarine. This edible oil and fat composition contains ≥ 1 mass% and < 5 mass% of a diacylglyceride based on the whole amount of oil and fat. The diacylglyceride has (1) ≤ 50 mass% of the total content of palmitic acid residue and stearic acid residue in the total fatty acid residue, (2) ≤ 70 mass% of the content of oleic acid in the total fatty acid residue, and (3) a melting point of ≤ 15[deg.]C. The present invention also provides a bubbles-containing water-in-oil emulsified grease composition containing the invented edible grease composition, water, and flavoring agent(s).
Owner:KAO CORP
Controlled release peptide formulations
ActiveUS20140162944A1Little and no preparationLittle and preparationSenses disorderPeptide/protein ingredientsLiquid crystallineControlled release
The present invention relates to compositions forming a low viscosity mixture of: a) 20-80 wt. % of at least one diacyl glycerol and / or a tocopherol; b) 20-80 wt. % of at least one phosphatidyl choline (PC); c) 5-20 wt. % of at least one biocompatible, organic mono-alcoholic solvent; d) up to 20 wt. % polar solvent e) at least one peptide active agent; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, and to pre-filled administration devices and kits containing the formulations.
Owner:CAMURUS AB
Robust controlled-release formulations
ActiveUS20140348903A1Aggregation is suppressedImprove efficiencyAntibacterial agentsOrganic active ingredientsLiquid crystallinePre formulation
The present invention relates to compositions forming a low viscosity mixture of: a. at least one diacyl glycerol and / or at least one tocopherol; b. at least one phospholipid component comprising phospholipids having i. polar head groups comprising more than 50% phosphatidyl ethanolamine, and ii. two acyl chains each independently having 16 to 20 carbons wherein at least one acyl chain has at least one unsaturation in the carbon chain, and there are no more than four unsaturations over two carbon chains; c. at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein optionally at least one bioactive agent is dissolved or dispersed in the low viscosity mixture; and wherein the pre-formulation forms, or is capable of forming, at least one non-lamellar liquid crystalline phase structure upon contact with an aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, and to pre-filled administration devices and kits containing the formulations.
Owner:CAMURUS AB
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