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Blood coagulant for blood collection container

A blood coagulant and blood collection technology, which is applied in the direction of material inspection products, enzyme stability, biological testing, etc., can solve the problems of interference in biochemical detection, specimen hemolysis, interference of test results, etc., and achieve the effect of long storage time

Active Publication Date: 2011-10-12
SHANGHAI KEHUADIAGNOSITIC MEDICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because kaolin, cephalin and other coagulation-promoting substances contain a large amount of metal or non-metallic ion components, such as potassium, sodium, calcium and other ionic components contained in kaolin, these exogenous ionic components will seriously interfere with biochemical detection, while cephalin The contained triglycerides, cholesterol, and other lecithin components will also interfere with the test results, and the hemolytic lecithin will even cause hemolysis of the specimen, making the specimen unusable for test detection
[0004] Domestic patent 200680008053.1 discloses a blood coagulation accelerator, which uses silicone oil, polyvinylpyrrolidone, polyoxyalkylene, etc. , and the structure of the blood coagulant of this invention cannot meet the indicators and requirements of rapid blood coagulation during blood testing, no hemolysis after coagulation, and prevention of blood centrifugation to form fibrin filaments

Method used

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  • Blood coagulant for blood collection container
  • Blood coagulant for blood collection container

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Measure 1000 milliliters of absolute ethanol solution and place it in a Erlenmeyer flask with a volume of 2000 milliliters, place the Erlenmeyer flask on a magnetic stirrer, weigh 2 grams of hydrophobic silica particles with a particle diameter of 10 nm, add the above absolute ethanol In the solution, turn on the magnetic stirring function to disperse the silica micropowder evenly in the ethanol solution; take another 10mL of thrombin with an activity of 2000IU / mL and add it to the above solution, keep stirring, and then weigh 50mg of phosphatidylethanolamine and add it to the above solution. solution, and finally 10 mL of polydimethylsiloxane was added, and stirring was continued for 10 minutes.

Embodiment 2

[0019] Measure 1000 milliliters of absolute ethanol solution and place it in a Erlenmeyer flask with a volume of 2000 milliliters, place the Erlenmeyer flask on a magnetic stirrer, weigh 3 grams of hydrophobic silica particles with a particle diameter of 16 nm, add the above-mentioned absolute ethanol In the solution, turn on the magnetic stirring function to disperse the silica micropowder evenly in the ethanol solution; take another 15 mL of thrombin with an activity of 2000 IU / mL and add it to the above solution, and keep stirring, then weigh 80 mg of phosphatidylethanolamine and add it to the above solution. solution, and finally 12 mL of polydimethylsiloxane was added, and stirring was continued for 10 minutes.

Embodiment 3

[0021] Measure 1000 milliliters of absolute ethanol solution and place it in a Erlenmeyer flask with a volume of 2000 milliliters, place the Erlenmeyer flask on a magnetic stirrer, weigh 4 grams of hydrophobic silica particles with a particle diameter of 10 nm, add the above-mentioned absolute ethanol In the solution, turn on the magnetic stirring function to disperse the silica micropowder evenly in the ethanol solution; take another 20mL of thrombin with an activity of 2000IU / mL and add it to the above solution, and keep stirring, then weigh 50mg of phosphatidylethanolamine and add it to the above solution. solution, and finally 12 mL of polydimethylsiloxane was added, and stirring was continued for 10 minutes.

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Abstract

The invention relates to the technical field of blood coagulants, in particular to a blood coagulant for a blood collection container. The blood coagulant is characterized by consisting of a blood wall attachment preventing agent, thrombin, phosphatidyl ethanolamine, silica micropowder and ethanol, wherein the ethanol is a solvent; and the blood wall attachment preventing agent, the thrombin, the phosphatidyl ethanolamine and the silica micropowder are solutes. The blood coagulant can be applied to vacuum blood collection tubes or other non-vacuum blood collection containers. By the blood coagulant, blood collected into the container can be coagulated within 10 minutes at room temperature of between 2 and 35 DEG C; and serum can be subjected to centrifugal separation within 15 to 30 minutes. The blood coagulant has long retention time, little influence on coagulation speed by temperature and no influence on biochemical and immunological test detection indexes including ion ingredients, and is not influenced by the materials of the blood collection containers, so no matter glass tubes or plastic tubes are used, hemolysis is not caused and blood is not attached to the walls.

Description

[technical field] [0001] The invention relates to the technical field of blood coagulation accelerators, in particular to blood coagulation accelerators used in the manufacture of vacuum blood collection tubes or other non-vacuum blood collection containers, specifically a blood coagulation accelerator used in blood collection containers. [Background technique] [0002] Serum is one of the main specimens for clinical biochemical and immune tests. At present, the means for medical institutions to obtain serum samples is mainly to collect venous blood and centrifuge it after the blood is completely coagulated. Under normal circumstances, it takes more than 60 minutes for an isolated blood sample to completely coagulate, which is difficult to meet the needs of laboratories for rapid testing. [0003] At present, the containers used by medical institutions to collect venous blood samples mainly include vacuum blood collection tubes or disposable syringes to collect blood sample...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N9/96G01N33/86
Inventor 朱德新李健
Owner SHANGHAI KEHUADIAGNOSITIC MEDICAL PRODS
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