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Method for constructing physiological toxicokinetic model of nonylphenol in rat

A technology of mechanical model and construction method, which is applied in the field of toxicology research and application, and can solve the problem that the establishment of PBTK model is still blank

Active Publication Date: 2019-01-29
SOUTHEAST UNIV
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  • Description
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  • Application Information

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Problems solved by technology

In terms of phenolic EDCs, only the PBTK model of bisphenol A has been established at present, and the establishment of the relevant PBTK model is still blank

Method used

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  • Method for constructing physiological toxicokinetic model of nonylphenol in rat
  • Method for constructing physiological toxicokinetic model of nonylphenol in rat
  • Method for constructing physiological toxicokinetic model of nonylphenol in rat

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Embodiment Construction

[0043] The technical solutions of the present invention will be further described in detail below in conjunction with specific implementation examples.

[0044] The invention provides a method for constructing a physiological toxicokinetic model of rat nonylphenol, including establishing a model structure, establishing a model differential equation, collecting model parameters, model optimization, model verification and model fitting effect evaluation. Specific steps are as follows:

[0045] (1) Establish the physiological toxicokinetic model structure of nonylphenol in rats

[0046] In the present invention, the rat PBTK model is used to describe the dynamic concentration change in the rat body, the hypothesis of the rat PBTK model is proposed and the model structure is established according to the physiological anatomy of the rat and the metabolic characteristics in the rat body.

[0047] The model structure diagram is also called the blood circulation diagram. Its design d...

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Abstract

The invention provides a method for constructing a physiological toxicokinetic model of nonylphenol in a rat, the method mainly comprises the following steps: (1) establishing a model structure; (2) establishing a model differential equation; (3) establishing and collecting model parameters; (4) performing model optimization; (5) performing model verification; and (6) performing model effect evaluation. The physiological toxicokinetic model of the nonylphenol established by the method disclosed by the invention has the characteristic of species extrapolation, so that the method has a special value in toxicant toxicity and risk evaluation. Compared with a classical compartmental model, the compartments and most parameters of the model have the physiological significance, the exposure leveland the metabolic change condition of toxicants in blood and other tissue organs can be predicted, and the model can assist in the research of the substance toxicology mechanism and improve the risk degree evaluation process.

Description

technical field [0001] The invention relates to a method for constructing a physiological toxicokinetic model of rat nonylphenol, belonging to the field of toxicology research and application. technical background [0002] Environmental endocrine disruptors (EDCs), also known as environmental estrogens, are widely present in the environment, can be enriched and amplified through the food chain, and finally enter the body. Among them, the pollution of phenolic EDCs (bisphenol A, alkylphenol, etc.) is more closely related to life. Most closely, its toxicity is mainly focused on endocrine disruption and toxic effects on the reproductive system. As a typical phenolic EDCs, nonylphenol (NP) is widely used in food, and its pollution status in food is worrying. It has been detected in food, and the potential risks brought by it need to be paid attention to urgently. [0003] The content detected in food can only represent the total amount ingested by the body (external exposure d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16C10/00G16C20/10
Inventor 许茜刘腾
Owner SOUTHEAST UNIV
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