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Dynamic PET (Positron Emission Tomography) image reconstruction and tracing kinetic parameter estimation method based on image segmentation

A dynamic parameter and image reconstruction technology, applied in the field of PET imaging, can solve the problems of segmentation algorithm measurement noise sensitivity and dependence, and achieve the effect of enhancing uniformity and good reconstruction results

Active Publication Date: 2017-09-08
ZHEJIANG UNIV
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Problems solved by technology

However, no matter looking at this problem from the perspective of PET image plane or dynamic parameters, the accuracy of the segmentation algorithm based on the reconstruction result always depends on the accuracy of the reconstruction result in the previous step, which cannot solve the problem that the segmentation algorithm is sensitive to measurement noise

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  • Dynamic PET (Positron Emission Tomography) image reconstruction and tracing kinetic parameter estimation method based on image segmentation
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  • Dynamic PET (Positron Emission Tomography) image reconstruction and tracing kinetic parameter estimation method based on image segmentation

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[0059] In order to describe the present invention more specifically, the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0060] The present invention based on the region segmentation dynamic PET and dynamic parameter joint reconstruction method, comprises the following steps:

[0061] (1) Establish measurement data matrix Y and system matrix G according to the dynamic PET scanning mode.

[0062] The scanning process of the dynamic PET is divided into a certain number of time frames according to the needs, and the counting vectors collected by the detector in each time frame can be constructed in the order of time to construct a dynamic PET measurement data matrix Y; and count each The probability that the photons emitted at the pixel are received by each detector, so as to obtain the system matrix G.

[0063] (2) According to the distribution of positron species and time f...

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Abstract

The invention provides a dynamic PET (Positron Emission Tomography) image reconstruction and tracing kinetic parameter estimation method based on image segmentation. A statistics reconstruction model is combined with a model with physiological significance can be combined to more accurately combine a reconstruction result. When reconstruction and segmentation are coupled to one a combined or concurrent solving frame, for a segmentation task, the information of a noise model for carrying out modeling on original projection data can be obtained, and a segmentation-based result can enhance homogeneity in each area so as to realize a reconstruction result which more conforms to a true situation. Compared with other algorithms which singly reconstruct PET images or estimation kinetic parameters, the method can obtain a good reconstruction result. Through the combination of the performance of the method in simulated data experiments and true data experiments, compared with other algorithms which singly reconstruct PET images, the estimation kinetic parameters and image segmentation, the method disclosed by the invention can obtain a good reconstruction result.

Description

technical field [0001] The invention belongs to the technical field of PET imaging, and in particular relates to a dynamic PET image reconstruction and tracking kinetic parameter estimation method based on image segmentation. Background technique [0002] Positron Emission Tomography (PET) is a kind of nuclear medical imaging, which is gradually showing its important role in biomedical research and clinical diagnosis and treatment. By imaging the radioactive distribution of tracers injected into living organisms, PET imaging technology can detect abnormalities in cell metabolism at the molecular level, providing an effective basis for early diagnosis and prevention of diseases. Compared with the static PET imaging technology that can only provide the average distribution of radioactive intensity in biological tissues within a certain time window, dynamic PET imaging can obtain quantitative functional parameters that describe the life activities of living organisms based on d...

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Application Information

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IPC IPC(8): G06T7/00G06T7/11G06T7/136
Inventor 刘华锋余海青
Owner ZHEJIANG UNIV
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