37results about How to "Antitumor activity" patented technology

The present invention relates to pharmaceutical compositions comprising a sulfonamide-including compound in combination with an angiogenesis inhibitor.

The present invention relates to compositions and methods involving antitumor agents derived from bacteria. In particular, the present invention provides the ansamitocin biosynthetic gene cluster for the production of novel maytansinoid analogs with potent antitumor activity and reduced human toxicity.

A peptide which selectively inhibits α_vβ₃ integrin which comprises the deamidation product of a peptide comprising the NGR motif.

This invention relates to three-spiral lentina with beta-(1-3)-D-glucan having 20-30%(1-6) chain connected glucose side chains as main chain. It shows three chains in water, with average molecular weight of 20,000-200,000. It is produced by: cutting dry shiitake, removing fat by Suo extraction, soaking in normal saline, centrifuging, extracting remains at 100-130 degrees C, centrifuging, extracting remains in water solution of NaOH/NaBH4, adding acetic acid into extracting liquid to neutralize, decoloring supernatant, removing free protein, dialyzing, concentrating, and frozen drying. It has higher anti-tumor activity and can be used to prepare medicines or health-care products for improving immune ability and antitumor.

The present disclosure relates to a method of treating a solid tumour, wherein said method involves the use of an antibody to CD25. In particular, the antibody to CD25 is optimized for depletion of regulatory T cells (Treg) within tumours. The present invention also provides novel anti-CD25 antibodies and their combination with other anti-cancer drugs, such as immune checkpoint inhibitors, compounds that target cancer antigens or the inhibitory Fc receptor FcyR11b (CD32b).

The invention discloses panax japonicus polysaccharide. The main chain structure thereof is Beta-1 to 4-D glucan and heterosaccharide containing mannan, galactan and xylan branched chain, the weight-average molecular weight of the panax japonicus polysaccharide is 5,000 to 200,000, the intrinsic viscosity at 25 DEG C is 1 to 50ml/g, and the mole ratio of the three elements of C: H: O is 1: 2: 1. The method for preparing the panax japonicus polysaccharide comprises the following steps: after being dried, smashed and skimmed, the panax japonicus is extracted by neutral salt water solution or pure water, and the white panax japonicus polysaccharide which can be easily dissolved in water, be dissolved in DMSO and not be dissolved in methanol, ethanol and acetone is obtained by separation, saponin removal, decolorization, dehydration, protein removal, desalination and drying. The panax japonicus polysaccharide which is prepared by the invention has higher anti-tumor activity and promotion of immune activity, which can be used for preparing drugs or health care products for improving immune function and anti-tumor. The method for preparing the product is simple and easy to operation, and the sources of the needed raw materials are wide.

The invention relates to Lanthanum amino acid complex and its preparing process and application, wherein the complex has the chemical name of which has the chemical name of 10-phenanthroline-2-methylene}-alpha-phenylalanine lanthanum (III) complex, which has the structural formula disclosed in the specification, and is prepared by reacting 1,10-phenanthroline-2-formaldehyde with alpha-phenylalanine, reducing with NaBH4, coordinating with lanthanum (III), thus obtaining single core complex, then reacting the single core complex with terephthalic acid. The obtained compound can be used for cancer resistance, which has better anti-cancer activity and wide spectrum.

The invention belongs to the field of medical technology and discloses a genistein derivative with a structure shown by formula I in the specification or a pharmaceutically acceptable salt thereof. The invention also discloses an application of the genistein derivative or the pharmaceutically acceptable salt thereof in preparing a tumor treating medicine, an application in preparing an inflammation-related tumor treating medicine and an application in preparing a medicine inhibiting tumor cell invasion and migration. The genistein derivative disclosed by the invention generates a growth inhibiting and killing effect on tumor cells to realize an anti-tumor effect and has broad-spectrum anti-tumor activity while the effect is relatively good; the genistein derivative promises a perfect treatment effect on the AOM/DSS induced inflammation related tumor; and with relatively good ability of inhibiting tumor cell invasion and migration, the genistein derivative can be used for preparing a medicine inhibiting tumor migration and can be made into tumor migration inhibiting medicines of various dosage forms, thereby providing a better choice for tumor patients.

The invention relates to the field of medicinal chemistry and in particular relates to an imidazole [4,5-c] pyridine-7-methanamide derivative (I), wherein R is defined in the specification. Pharmacodynamic tests proof that the derivative compound provided by the invention can serve as a tumour therapeutic agent and especially the derivative compound has extremely strong anti-tumour effect when being combined with cis-platinum. The invention also discloses a preparation method of the derivative compound and a pharmaceutical composition comprising the derivative compound.

The invention relates to a preparation method for two novel compounds with antitumor activity extracted from isodon excisoides and an application of the two novel compounds. The novel compounds are extracted from the isodon excisoides and are applied to the preparation of antitumor drugs. The method comprises the steps: adding water into the isodon excisoides, carrying out boiling extraction, introducing an extract sample to a macroporous adsorption resin column, and carrying out gradient elution by using water and ethanol, so as to obtain Fr. A, Fr. B, Fr. C and Fr. D; subjecting part of Fr. C to gel column chromatography and methanol-water gradient elution, so as to obtain Fr. C1, Fr. C2, Fr. C3 and Fr. C4; and subjecting part of Fr. C2 to silica-gel column chromatography and petroleum ether-acetone and methanol gradient elution, so as to obtain Fr. B1-1, Fr. B1-2, Fr. C2a, Fr. C2b, Fr. C2c and Fr. C2d, subjecting Fr. C2c to methanol recrystallization so as to obtain an acetonitrile-water for white powder as eluate, carrying out semipreparative HPLC purification, collecting chromatographic peaks at 56.4min and 61.2min, separately placing products in a solvent, and carrying out anhydrous sodium sulfate dehydrating and nitrogen gas drying-up, thereby obtaining a compound 1 and a compound 2. The preparation method provided by the invention is easy in operation, high in orienting property, high in separating rate, high in efficiency and high in product purity and can be effectively used for preparing the antitumor drugs.

The present invention relates to a kit-of-parts comprising and a composition comprising a polyplex comprising a double stranded RNA (dsRNA) and a polymeric conjugate comprising a polyethyleneimine (PEI), one or more polyethylene glycol (PEG) moieties and one or more targeting moieties, and wherein each of said one or more targeting moieties is capable of binding to a cancer antigen; and at least one antibody, wherein said at least one antibody is capable of modulating an immune checkpoint protein. Further the invention relates to this composition or kit-of-parts for use in the treatment of cancer.