The invention discloses a method for purifying a
cangrelor intermediate. The invention provides a method for purifying a
cangrelor intermediate I; the method comprises the steps of 1, mixing a
cangrelor intermediate I crude product with an
organic solvent to form a mixture, enabling the mixture to react with basic salt or
ammonia water, and then extracting to obtain a water phase; 2, removing water in the water phase, then adding an
alcohol solvent into the water phase, and filtering or centrifuging to obtain a
filter cake; 3, adjusting the pH of the obtained
filter cake to 2-3 in water, and filtering or centrifuging to obtain another
filter cake; 4, adjusting the pH of the obtained filter cake to 7-8 in the
alcohol solvent, and filtering to obtain the cangrelor intermediate I. The method for purifying the cangrelor intermediate does not adopt a reverse
silica gel separation method and cation exchange resin which is expensive, cumbersome in operation and long in purification time; the method is simple in operation, short in reaction time, high in yield and high in purity of a prepared product; after the method is used, the
high performance liquid chromatography (HPLC) purity is more than 99.0%; the method is low in production cost and suitable for industrial production. The
structural formula of the cangrelor intermediate I is described in the description.