64 results about "PCI - Percutaneous coronary intervention" patented technology

The present invention relates to compounds for treatment that protects the endothelium, prevents pathologic thrombus formation in the microcirculation and preserves platelet number and function and thus may be related to treatment or prevention of ischemic events in patients with cardiovascular disease. The present invention is particularly useful for patients having or being at increased risk of development of an ischemic event such as an acute myocardial infarction and / or no-reflow phenomena and / or ischemia-reperfusion injury by administration of agent(s) modulating and / or preserving endothelial integrity. The compounds may be administered in combination with standard treatment of acute cardiovascular ischemic events such as Platelet inhibitors such as aspirin (ASA), Thienopyridins, GPIIb / IIIa inhibitors), Parenteral anticoagulants such as unfractioned heparin (UFH), bivalirudin, enoxaparin, and fondaparinux, Verapamil, Adenosine, Sodium nitroprusside, Nitroglycerin, Epinephrine, Beta-blockers and surgical methods such as percutaneous coronary intervention (PCI), PCI with thrombus aspiration, PCI with stents.

The subject guide catheter extension / pre-dilatation system includes an outer delivery sheath, an inner member extending within the sheath, and a mechanism for engagement / disengagement of the inner member to / from the sheath. The inner member is configured with a tapered distal tip having a delivery micro-catheter and a pre-dilatation balloon member attached to the tapered distal tip. The guidewire and a guide catheter are advanced to the vicinity of the treatment site within a blood vessel. Subsequently, the inner member and outer delivery sheath, in their engaged configuration, are advanced along the guidewire inside the guide catheter towards the site of treatment. At the treatment site, the balloon member is inflated for pre-dilatation treatment. The inner member is disengaged and retracted from the outer delivery sheath, and a stent is delivered to the treatment site.

Provided is a vascular stent used in percutaneous coronary intervention (PCI) which is specially designed for multiple drug loading and improved drug elution, including: a plurality of ring structures extending in the longitudinal direction of the vascular stent, including a plurality of struts disposed in a zigzag formation and connected to each other to form a cylindrical loop; and a plurality of link structures disposed between the ring structures and connecting the ring structures in the longitudinal direction of the vascular stent, wherein each of the struts in a ring structure is connected to adjacent struts in the same ring structure through one of a plurality of linking ends, a slot loaded with drugs is formed in the strut in the longitudinal direction of the strut, and a multi-layer structure comprising a plurality of layers of drugs is loaded in the slot. The vascular stent effectively inhibits restenosis by loading a large amount of a drug or various types of drugs in multiple layers in slots of struts in the vascular stent and controlling elution of the drugs, and can be easily installed in a serpentine coronary artery with excellent flexibility. In addition, the link structure of the vascular stent is disposed in a symmetric formation, and thus, side branch accessibility is excellent and an additional coronary intervention can be performed easily in a branched artery.

A method of treating or preventing a disease or condition in a subject that was previously treated with at least one thienopyridine is described. The method includes administering to the subject an effective amount of at least one reversible, short-acting P2Yi2 inhibitor. The described method can be used for subjects diagnosed with symptoms such as stable or unstable angina, vascular ischemic events, atherosclerosis, acute coronary syndrome, as well as STEMi or N-STEMI. The described method can also be used for patients having previously received a stent, such as a bare metal stent or a drug-eluting stent, and the treatment or prevention of stent thrombosis. The method can be used prior to, during, or after an invasive procedure such as coronary artery bypass grafting, percutaneous coronary intervention, or other general surgical procedure.

The invention belongs to the field of biomedical engineering and particularly relates to an intrusive assisted circulation device used in the department of cardiac surgery. The device is characterized in that a magnetic drive mode is adopted for power transmission. The device is divided into two parts, namely an invitro driving device and an auxiliary device capable of being implanting into a human body through percutaneous coronary intervention, wherein an invitro driving device main body is a rotating magnetic field generation device capable of generating a rotating magnetic field which is strong enough; the auxiliary device implanted into the human body is internally provided with a minitype axial flow pump; a high-energy magnet is embedded in an impeller of the minitype axial flow pump, and is driven to rotate by the rotating magnetic field so as to push blood to flow; and the pump is implanted into the part, crossing over an aortic valve or pulmonic valve, of a heart, so as to play a role in assisting the heart to pump blood, thus effectively relieving the cardiac muscle load and assisting heart recovery.

The invention relates to a percutaneous coronary intervention radio frequency ablation electrode catheter which comprises an outer pipe, a core pipe, a handle, a core pipe handle, electrodes, guide wires and electrode plugs, wherein the core pipe is arranged in the outer pipe; the handle is fixedly connected with the near end of the outer pipe; the core pipe handle is fixedly connected with the near end of the core pipe; the guide wires are connected with the electrodes; the electrode plugs are connected with a radio frequency ablatograph; the far end of the outer pipe is provided with an electrode bearing device; the far end of the outer pipe is fixedly connected with that of the core pipe; the electrode bearing device is provided with a plurality of strips; the strips are distributed in the circumferential direction of the outer pipe and are arranged in a staggered manner in the axial direction; the electrodes are fixed at the middle parts of the strips; and when the outer pipe and the core pipe oppositely move, the electrodes on the strips are hunched up in the radial direction and are distributed in a staggered manner. The radio frequency ablation electrode catheter greatly reduces damage to renal artery and moreover, the maximum diameter of the electrode bearing device at the far end of the radio frequency ablation electrode catheter can be correspondingly regulated according to the diameter of the blood vessel of a patient.

A system configured to assess the severity of blockages in blood vessels, and in particular stenosis in blood vessels, is disclosed. It is further disclosed that measurements of the vessel are provided which allow assessment of the vessel (and in particular any stenosis or lesion of the vessel), simulating diagnostic visualization using the first and second visualization means. Displaying an image of a vessel on a first visualization device with a theranostic visualization based on pressure measurements obtained and on a second visualization device displaying an image of a vessel with a diagnostic visualization based on pressure measurements obtained is disclosed. A portion of the image, wherein the portion of the image of the vessel displayed on the second visualization device is a magnified view of the region of interest of the vessel.

The subject guide catheter extension system with a micro-catheter delivery catheter includes an outer sheath, an inner member extending within the sheath, and a mechanism for engagement / disengagement of the inner member to / from the sheath. Several mechanisms of engagement / disengagement between the inner and outer members are provided including a friction mechanism, threaded mechanism, pull away sheath, and engagement / disengagement mechanism for pusher's handles. The sheath and the inner member are modified for different engagement / disengagement mechanisms operation. A micro-catheter delivery system provides for an improved atraumatic crossability to the treatment site in an expedited and simplified fashion. During a procedure, a guidewire along with a guide catheter are advanced to the vicinity of the treatment site within a blood vessel. Subsequent thereto, the subject guide catheter extension system is manipulated to advance the micro-catheter along the guidewire inside the guide catheter towards and beyond the site of interest. Once the micro-catheter is in place, the outer sheath slides along the micro-catheter until reaching the lesion, and then the inner member is removed from the sheath, and the sheath then is ready for passing the treatment catheter (stent / balloon) towards the lesion to be treated.

Apparatus, systems and methods for determining and presenting cardiac treatment options, for assessing the severity of blockages in vessels, particularly stenosis in vessels, by obtaining images of vessels, obtaining images of said vessels Pressure measurements, generate diagnostic imaging, determine treatment options, and generate predictive imaging. Various images and options are displayed on the medical personnel display and the patient display.

The invention relates to a ticagrelor dispersible tablet for patients with acute coronary syndrome, including patients receiving drug therapy and percutaneous coronary intervention (PCI) treatment. The ticagrelor is used as a raw material, and auxiliary materials are added to prepare ticagrelor dispersible tablets. The dispersible tablet of the present invention disintegrates quickly, absorbs quickly, and has high bioavailability; it is convenient to take; it has less intestinal residue and less side effects; There will be no sticking phenomenon in the process, which is conducive to the realization of industrialized production.

The invention relates to a method for operating a diagnostic apparatus with an x-ray system for generating x-ray images, which has an x-ray device and an image system for the x-ray device, with a system for determining the position of objects, for example a measurement catheter, and a control facility for at least the x-ray system, whereby after an x-ray pulse a first read-out containing useful information is saved as an x-ray image, immediately afterwards a second read-out not containing useful information is saved as an interference image, and the x-ray image is corrected for the purpose of minimizing interference. Such diagnostic apparatuses are used in various medical procedures, for example in PCI (Percutaneous coronary intervention) and cardiac EP (electrophysiology) interventions.

The invention relates to a diagnostics device and to a method for the operation thereof comprising an X-ray system for producing X-ray images, the system comprising an X-ray device and an image system for the X-ray device, and a system for locating objects, wherein adjusting means for changing the frequency of at least one of the two systems are provided, by way of which the two systems can be coordinated with one another such that interference within successive X-ray images is virtually static, and the image system comprises a correcting device which is constructed such that the static interference is eliminated. Diagnostics devices of this type are used in various medical procedures, for example in PCI (Percutaneous Coronary Intervention) and Cardiac EP (electrophysiology) interventions.

The invention provides new uses for specific binders to the A1 domain of the von Willebrand Factor (vWF), in particular the use in patients with stable angina undergoing elective percutaneous coronary intervention. Furthermore, dosing schedules and use of suitable assays such as RIPA and RICO in the particular disease settings are provided.