Premix for improving urinary tract health of pets and preparation method thereof

Abstract

The invention belongs to the field of pet food processing, and relates to a premix for improving the health of urinary tracts of pets. The premix comprises the following components in parts by weight: 25-35 parts of Chinese yams, 25-35 parts of poria cocos, 15-25 parts of dandelions, 15-25 parts of centella asiatica, 15-25 parts of semen plantaginis, 5-15 parts of rhizoma polygonati, 5-15 parts of dogwood and 5-15 parts of Chinese wolfberry fruits. By adding the premix disclosed by the invention into daily ration, the concentrations of cat blood creatinine, urea nitrogen and blood oxalic acid are reduced, the absorption and excretion of oxalic acid are influenced, and the formation of calcium oxalate calculi is prevented. The premix disclosed by the invention can relieve the kidney toxicity of sodium oxalate to cats, improve the physiological indexes of the kidneys, reduce the formation of calcium oxalate calculi and provide basic guarantee for the treatment of chronic urinary system diseases. The premix disclosed by the invention can be used for improving the urinary tract health of cats.

Description

Technical Field

[0001] The invention belongs to the field of pet food processing and relates to a premix for improving the urinary tract health of a pet and a preparation method thereof. Background Art

[0002] Feline lower urinary tract syndrome (FLUTS) is a syndrome of posterior urinary tract diseases in cats caused by various reasons. It does not represent a single disease symptom and may include one or all of the following diseases: urethritis, cystitis, urethral plugs (soft plugs, gritty plugs or true stones) or obstructive uropathy (partial or complete obstruction) caused by urethral stricture.

[0003] Common causes include cystitis, urethritis (functional stenosis caused by inflammation and spasm), urethral obstruction, urolithiasis, urethral anatomical abnormalities (stenosis, compression of periurethral tissue), etc.

[0004] Clinically, it is characterized by dysuria, painful urination, straining, frequent urination, hematuria, and urethral obstruction.

[0005] When cystitis and urethritis occur, the symptoms include frequent urination, difficulty urinating, dribbling urination, hematuria and painful urination; when the urethra is blocked, the symptoms include anuria, extremely full bladder, licking of the external genitalia, abdominal pain and even bladder rupture; when the urinary tract is infected, the urine is turbid (pyuria), and when acute urinary retention occurs, it can lead to acute renal failure or uremia, and there is a strong smell of urea in the mouth.

[0006] Symptoms of urinary stones are related to the severity of urethral obstruction. Incomplete urethral obstruction causes painful urination, with intermittent, dripping or fine urine, and only small amounts of urine. Sometimes the urine contains blood, with a higher amount of blood in the early stages of urination. Complete urethral obstruction leads to complete urinary retention, with the bladder extremely full. Despite frequent straining, the cat experiences no urine, and palpation of the bladder causes severe pain.

[0007] Western medicine usually uses atropine to reduce smooth muscle contraction after sedating the cat, or injects hyaluronidase to reduce the surface tension of the embolus and promote its excretion, and uses catheterization to drain urine. If the catheter cannot be inserted, bladder puncture can be used to quickly drain urine, and the bladder is flushed with 1% potassium permanganate water to achieve the purpose of antibacterial, and antibiotics are infused.

[0008] Western medicine often uses antibiotics to treat feline urinary tract infections, but with the increasing problems of antibiotic abuse and drug resistance, it is particularly important to find safe alternative treatments.

[0009] It is of great significance to develop a premix that can significantly improve the urinary tract health of cats and is safe to use for application in pet food. Summary of the Invention

[0010] The present invention aims to provide a premix for improving the urinary tract health of pets and a preparation method thereof. The premix of the present invention significantly improves the urinary tract health of cats and reduces the formation of calcium oxalate stones.

[0011] To achieve the above objectives, this application adopts the following technical solutions:

[0012] In a first aspect, the present invention provides a premix for improving the urinary tract health of a pet, the premix containing the following components in parts by weight: 25-35 parts of yam, 25-35 parts of poria cocos, 15-25 parts of dandelion, 15-25 parts of centella asiatica, 15-25 parts of plantain seeds, 5-15 parts of polygonatum, 5-15 parts of cornus officinalis, and 5-15 parts of wolfberry.

[0013] In one embodiment of the present invention, the premix contains the following components in parts by weight: 30 parts of Chinese yam, 30 parts of Poria cocos, 20 parts of Taraxacum mongolicum, 20 parts of Centella asiatica, 20 parts of Plantago seed, 10 parts of Polygonatum sibiricum, 10 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0014] In one embodiment of the present invention, the premix contains the following components in parts by weight: 25 parts of Chinese yam, 35 parts of Poria cocos, 25 parts of dandelion, 25 parts of Centella asiatica, 15 parts of Plantago seed, 15 parts of Polygonatum sibiricum, 5 parts of Cornus officinalis, and 15 parts of Lycium barbarum.

[0015] In one embodiment of the present invention, the premix contains the following components in parts by weight: 35 parts of Chinese yam, 25 parts of Poria cocos, 15 parts of Dandelion, 15 parts of Centella asiatica, 25 parts of Plantago, 5 parts of Polygonatum, 15 parts of Cornus officinalis, and 5 parts of Lycium barbarum.

[0016] In a second aspect, the present invention provides a method for preparing the above-mentioned premix, which comprises premixing a formula amount of Chinese herbal medicines including yam, poria, dandelion, plantain seed, centella asiatica, polygonatum, cornus officinalis, and wolfberry, crushing the mixture, and sieving the mixture to obtain a premix for improving the urinary tract health of pets.

[0017] In a third aspect, the present invention provides use of the above-mentioned premix for improving the urinary tract health of pets in preparing pet feed.

[0018] Furthermore, the pet is a cat or a dog.

[0019] Furthermore, the premix for improving the urinary tract health of pets of the present invention reduces the formation of calcium oxalate stones.

[0020] The dosage of the premix for improving the urinary tract health of pets is 0.5%-1.5% of the basic diet.

[0021] Furthermore, the amount of the premix for improving the urinary tract health of pets is 0.8% of the basic diet.

[0022] The premix of the present invention is added with the following components: Chinese yam, Poria cocos, dandelion, Plantago seed, Centella asiatica, Polygonatum sibiricum, Cornus officinalis, and Lycium barbarum. Among them, Cornus officinalis nourishes kidney yang, warms and nourishes the liver and kidneys, Polygonatum sibiricum nourishes the spleen and kidney qi, strengthens the spleen and kidneys, Lycium barbarum nourishes liver blood, nourishes the liver and kidneys, and Chinese yam nourishes spleen yin, consolidates the kidneys and improves essence. The four Chinese herbs are used together to nourish the internal organs, strengthen the foundation and replenish the essence, strengthen the functions of the spleen, kidney, and liver, and restore the power of water metabolism. Plantago seed drains kidney turbidity, relieves stranguria and relieves turbidity, Centella asiatica clears the liver and detoxifies, and eliminates spleen dampness and turbidity, Dandelion drains liver fire, clears heat and detoxifies, and Poria drains spleen dampness, strengthens the spleen and eliminates dampness. The four herbs used together can clear damp heat, stones, inflammation, and balance the tonics to avoid deficiency and inability to be replenished. The whole prescription is both attacking and replenishing, strengthening the foundation and replenishing the essence, treating both the symptoms and the root causes, and replenishing both the innate and acquired.

[0023] The beneficial effects achieved by the present invention are:

[0024] Adding the premix of the present invention to a cat's diet reduces blood creatinine, urea nitrogen, and oxalate concentrations, impacting oxalate absorption and excretion, and preventing the formation of calcium oxalate stones. The premix of the present invention can alleviate the nephrotoxicity of sodium oxalate in cats, improve renal physiological parameters, and reduce the formation of calcium oxalate stones, providing a foundation for the treatment of chronic urinary system diseases. The premix of the present invention can improve urinary tract health in pets. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the specific implementation methods.

[0026] Figure 1 Comparison of serum oxalate concentrations in each group, compared with group C, & P<0.05, && P<0.01; compared with group M, * P<0.05, ** P<0.01; compared with S1 group, # P<0.05, ## P<0.01. DETAILED DESCRIPTION

[0027] In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0028] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below with reference to the embodiments.

[0029] The raw materials in the present invention are all purchased from commercial sources.

[0030] Example 1

[0031] A premix for improving the urinary tract health of pets contains the following components in parts by weight: 30 parts of Chinese yam, 30 parts of Poria cocos, 20 parts of dandelion, 20 parts of Centella asiatica, 20 parts of Plantago seed, 10 parts of Polygonatum sibiricum, 10 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0032] The preparation method comprises the following steps: premixing a formula amount of Chinese herbal medicines including Chinese yam, Poria cocos, dandelion, plantain seed, Centella asiatica, Polygonatum sibiricum, Cornus officinalis and wolfberry, crushing the mixture and sieving the mixture to obtain a premix for improving the urinary tract health of pets.

[0033] Example 2

[0034] A premix for improving the urinary tract health of a pet contains the following components in parts by weight: 25 parts of Chinese yam, 35 parts of Poria cocos, 25 parts of dandelion, 25 parts of Centella asiatica, 15 parts of Plantago seed, 15 parts of Polygonatum sibiricum, 5 parts of Cornus officinalis, and 15 parts of Lycium barbarum.

[0035] The preparation method is as in Example 1.

[0036] Example 3

[0037] A premix for improving the urinary tract health of a pet contains the following components in parts by weight: 35 parts of Chinese yam, 25 parts of Poria cocos, 15 parts of dandelion, 15 parts of Centella asiatica, 25 parts of Plantago seed, 5 parts of Polygonatum sibiricum, 15 parts of Cornus officinalis, and 5 parts of Lycium barbarum.

[0038] The preparation method is as in Example 1.

[0039] Example 4

[0040] A premix for improving the urinary tract health of a pet contains the following components in parts by weight: 28 parts of Chinese yam, 25 parts of Poria cocos, 18 parts of dandelion, 16 parts of Centella asiatica, 24 parts of Plantago seed, 8 parts of Polygonatum sibiricum, 15 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0041] The preparation method is as in Example 1.

[0042] Example 5

[0043] A premix for improving the urinary tract health of a pet contains the following components in parts by weight: 32 parts of yam, 24 parts of poria, 20 parts of dandelion, 18 parts of centella asiatica, 20 parts of plantain seeds, 5 parts of polygonatum, 10 parts of cornus officinalis, and 10 parts of wolfberry.

[0044] The preparation method is as in Example 1.

[0045] Example 6

[0046] A premix for improving the urinary tract health of a pet contains the following components in parts by weight: 25 parts of Chinese yam, 33 parts of Poria cocos, 24 parts of dandelion, 22 parts of Centella asiatica, 18 parts of Plantago seed, 6 parts of Polygonatum sibiricum, 6 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0047] The preparation method is as in Example 1.

[0048] Comparative Example 1

[0049] 30 parts of Poria cocos, 20 parts of Herba Taraxaci, 20 parts of Centella asiatica, 20 parts of Plantago seeds, 10 parts of Fructus Corni, 10 parts of Lycium barbarum.

[0050] Compared with Example 1, the difference is that Chinese yam and polygonatum are not contained.

[0051] The preparation method is as in Example 1.

[0052] Comparative Example 2

[0053] 30 parts of Chinese yam, 30 parts of Poria, 20 parts of dandelions, 20 parts of Centella asiatica, 20 parts of Plantago seeds, 10 parts of Polygonatum.

[0054] Compared with Example 1, the difference is that Cornus officinalis and Lycium barbarum are not contained.

[0055] The preparation method is as in Example 1.

[0056] Comparative Example 3

[0057] 30 parts of Chinese yam, 20 parts of Centella asiatica, 20 parts of Plantago seeds, 10 parts of Polygonatum sibiricum, 10 parts of Cornus officinalis, 10 parts of wolfberries.

[0058] Compared with Example 1, the difference is that Poria cocos and Taraxacum mongolicum are not contained.

[0059] The preparation method is as in Example 1.

[0060] Comparative Example 4

[0061] 30 parts of Chinese yam, 30 parts of Poria cocos, 20 parts of dandelions, 10 parts of polygonatum, 10 parts of cornus officinalis, and 10 parts of wolfberries.

[0062] Compared with Example 1, the difference is that Centella asiatica and Plantago seed are not contained.

[0063] The preparation method is as in Example 1.

[0064] Comparative Example 5

[0065] 20 parts of Chinese yam, 20 parts of Poria, 10 parts of Herba Taraxaci, 10 parts of Centella asiatica, 10 parts of Plantago seeds, 20 parts of Polygonatum, 20 parts of Fructus Corni, 20 parts of Lycium barbarum.

[0066] Compared with Example 1, the difference is that the dosage ratio of the raw materials is changed.

[0067] Comparative Example 6

[0068] 30 parts of Chinese yam, 30 parts of Poria, 20 parts of Viola yedoensis, 20 parts of Centella asiatica, 20 parts of Plantago seeds, 10 parts of Rehmannia glutinosa, 10 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

[0069] Compared with Example 1, the difference is that Rehmannia glutinosa is used instead of Polygonatum sibiricum, and Viola yedoensis is used instead of Taraxacum mongolicum.

[0070] Study on the effect of the premix of the present invention on cat urinary tract health

[0071] 1. Experimental Methods

[0072] Fifty healthy pet cats, approximately two years old, were randomly divided into 10 groups of five cats each. Each cat was fed a 100g basal diet daily with ad libitum access to water. A dietary hyperoxalate model was established by adding sodium oxalate at 1% of the diet weight. Successful establishment of the dietary hyperoxalate model was assessed by body weight, hematology, ultrasound, and urinalysis.

[0073] The cats were grouped and fed as follows:

[0074] Group C was the blank control group, fed with the basal diet;

[0075] Group M was the model control group, which was fed with a basal diet supplemented with 1% sodium oxalate by weight;

[0076] Group S1 was fed with 0.8% of the premix of Example 1 and 1% by weight of sodium oxalate in the basal diet;

[0077] Group S2 was fed with 0.8% of the premix of Example 2 and 1% by weight of sodium oxalate in the basal diet;

[0078] Group S3 was fed with 0.8% of the premix of Example 3 and 1% by weight of sodium oxalate in the basal diet;

[0079] Group T1 was supplemented with 0.8% premix of Comparative Example 1 and 1% by weight of sodium oxalate in the basal diet;

[0080] T2 group was fed with 0.8% premix of Comparative Example 2 and 1% sodium oxalate by weight in the basal diet;

[0081] T3 group was fed with 0.8% premix of Comparative Example 3 and 1% sodium oxalate by weight in the basal diet;

[0082] T4 group was fed with 0.8% premix of Comparative Example 4 and 1% sodium oxalate by weight in the basal diet;

[0083] In the T5 group, 0.8% of the premix of Comparative Example 5 was added to the basal diet, and 1% by weight of sodium oxalate was added to the basal diet.

[0084] The basal diet was purchased from Shandong Shuake Pet Products Co., Ltd., and its raw materials included fresh chicken, corn, rice, beef meal, fish meal, duck fat, brewer's yeast powder, chicken liver powder, beet pulp granules, psyllium, kelp powder, and brewer's yeast cell walls; and its additives included natural steroid saponin, taurine, fructooligosaccharides, L-lysine, dl-a-tocopherol, vitamin A, vitamin D3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, folic acid, niacinamide, D-calcium pantothenate, choline chloride, sodium chloride, antioxidants, calcium iodate, zinc glycinate, glycine iron complex, glycine copper complex, and methionine manganese complex.

[0085] The experimental period was 28 days.

[0086] 2. Measurement indicators

[0087] After the experiment, blood was collected from all experimental cats by forearm cephalic vein blood sampling and placed in EDTA tubes. Creatinine, urea nitrogen and oxalate detection kits were used to detect the concentrations of creatinine, urea nitrogen and oxalate in the blood, respectively.

[0088] 3. Data Processing

[0089] GraphPad Prism 7.0 software was used for data processing and the quantitative data were The comparison among the groups was performed using one-way analysis of variance, and the difference was considered statistically significant when P < 0.05.

[0090] 4. Test results

[0091] Effects on cats' blood creatinine, urea nitrogen, and blood oxalate concentrations

[0092] Urea nitrogen can be used to check whether the body's urination function is normal; creatinine is a product of muscle metabolism, its concentration is related to the body's glomerular filtration capacity, and is often used to determine whether the glomerular filtration rate is impaired.

[0093] As shown in Table 1 , compared with group C, the serum creatinine and urea nitrogen concentrations in group M were significantly increased.

[0094] Compared with group M, the serum creatinine and urea nitrogen concentrations in groups S1, S2, and S3 were significantly decreased.

[0095] The effects of S1, S2, and S3 groups in reducing serum creatinine and urea nitrogen concentrations were significantly better than those of T1-T5 groups.

[0096] Table 1 Serum creatinine and urea nitrogen concentrations in each group

[0097]

[0098]

[0099] Note: Compared with group C, & P<0.05, && P < 0.01;

[0100] Compared with group M, * P<0.05, ** P < 0.01;

[0101] Compared with the S1 group, # P<0.05, ## P<0.01.

[0102] like Figure 1 As shown in Figure 3, compared with group C, the serum oxalate concentration in group M was significantly increased.

[0103] Compared with group M, the serum oxalate concentrations in groups S1, S2, and S3 were significantly decreased.

[0104] The effects of S1, S2, and S3 groups in reducing serum oxalic acid concentration were significantly better than those of T1-T5 groups.

[0105] It can be seen from the above experimental results that under the condition of the same premix dosage, changing the raw materials of the premix (Comparative Examples 1-4) and changing the dosage ratio of the premix (Comparative Example 5) will weaken the intervention effect of the premix on cat stones. The raw materials of the premix of the present invention synergize and enhance the therapeutic effect on cat calcium oxalate stones.

[0106] Adding the premix of the present invention to the diet reduces blood creatinine, urea nitrogen, and oxalate concentrations in cats, impacting the absorption and excretion of oxalate and preventing the formation of calcium oxalate stones. The premix of the present invention can alleviate the nephrotoxicity of sodium oxalate in cats, improve renal physiological parameters, and reduce the formation of calcium oxalate stones, providing a foundation for the treatment of chronic urinary system diseases. The premix of the present invention can improve urinary tract health in cats.

[0107] Application of the premix of the present invention in treating chronic urinary tract diseases in cats

[0108] 20 pet cats with chronic urinary tract diseases were selected, the age of the cats being between 3 and 5 years old, and the cats were randomly divided into two groups, namely, Example 1 group and Comparative Example 6 group. There were 10 cats in each group.

[0109] Inclusion criteria: The cat is in good condition; the cat has no other diseases; the cat's body functions are normal.

[0110] Exclusion criteria: cats with organ diseases; cats with abnormal organ function; cats with allergies to the study drugs; cats with abnormal consciousness.

[0111] The Example 1 group was fed with 1.2% of the Example 1 premix in the basal diet, and the Comparative Example 6 group was fed with 1.2% of the Comparative Example 6 premix in the basal diet. The experimental period was 30 days.

[0112] Indicator Observation

[0113] The efficacy evaluation criteria are as follows:

[0114] High efficiency: The cat's disease symptoms disappear, the cat's physical indicators tend to be normal, and the cat has no adverse reactions;

[0115] Markedly effective: The cat's disease symptoms are significantly improved, the cat's physical indicators are effectively improved, and the cat has mild adverse reactions;

[0116] Ineffective: The cat experienced no relief from the disease symptoms.

[0117] Comparison of clinical efficacy

[0118] The total effective rate of Example 1 group was better than that of Comparative Example 6 groups. The results are shown in Table 2.

[0119] Table 2 Comparison of clinical efficacy between the two groups

[0120] Group High efficiency / only Significantly effective / only Invalid / only Effectiveness / % Example 1 group 3 6 1 90 Comparative Example 6 2 5 3 70

[0121] The above specific embodiments are merely explanations of the present invention and are not limitations of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the embodiments as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. A premix for improving the urinary tract health of pets, characterized in that: The premix contains the following components in parts by weight: 25-35 parts of Chinese yam, 25-35 parts of Poria cocos, 15-25 parts of dandelion, 15-25 parts of Centella asiatica, 15-25 parts of Plantago seed, 5-15 parts of Polygonatum sibiricum, 5-15 parts of Cornus officinalis, and 5-15 parts of Lycium barbarum.

2. The premix for improving pet urinary tract health according to claim 1, characterized in that: The premix contains the following components in parts by weight: 30 parts of Chinese yam, 30 parts of Poria cocos, 20 parts of Taraxacum mongolicum, 20 parts of Centella asiatica, 20 parts of Plantago seed, 10 parts of Polygonatum sibiricum, 10 parts of Cornus officinalis, and 10 parts of Lycium barbarum.

3. The premix for improving the urinary tract health of pets according to claim 1, characterized in that: The premix contains the following components in parts by weight: 25 parts of Chinese yam, 35 parts of Poria cocos, 25 parts of dandelion, 25 parts of Centella asiatica, 15 parts of Plantago seed, 15 parts of Polygonatum sibiricum, 5 parts of Cornus officinalis, and 15 parts of Lycium barbarum.

4. The premix for improving the urinary tract health of pets according to claim 1, characterized in that: The premix contains the following components in parts by weight: 35 parts of Chinese yam, 25 parts of Poria cocos, 15 parts of Taraxacum officinale, 15 parts of Centella asiatica, 25 parts of Plantago seed, 5 parts of Polygonatum sibiricum, 15 parts of Cornus officinalis, and 5 parts of Lycium barbarum.

5. The premix for improving the urinary tract health of pets according to claim 1, characterized in that: The preparation method comprises the following steps: premixing a formula amount of Chinese herbal medicines including Chinese yam, Poria cocos, dandelion, plantain seed, Centella asiatica, Polygonatum sibiricum, Cornus officinalis and wolfberry, crushing the mixture and sieving the mixture to obtain a premix for improving the urinary tract health of pets.

6. Use of the premix for improving pet urinary tract health according to any one of claims 1 to 4 in preparing pet feed.

7. The use according to claim 6, characterized in that The pet is a cat or a dog.

8. The use according to claim 6, characterized in that The premix reduces the formation of calcium oxalate stones.

9. The use according to claim 6, characterized in that The amount of the premix for improving the urinary tract health of pets is 0.5%-1.5% of the basic diet.

10. The use according to claim 9, characterized in that The amount of the premix for improving the urinary tract health of pets is 0.8% of the basic diet.

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