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Medicinal composition of piperacillin sodium and sulbactam sodium

A technology of piperacillin sodium and sulbactam sodium, which is applied in the field of pharmaceutical preparations, can solve the problems of affecting clinical efficacy, poor storage stability of preparations, loss of calcium ions, etc., and achieves the effects of optimizing the preparation process, improving stability and using safety.

Active Publication Date: 2016-06-08
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The combined preparation of piperacillin sodium and sulbactam sodium has a large clinical dosage, definite curative effect and good market prospect, but the storage stability of the existing preparation is poor, which seriously affects the clinical curative effect
And in the prior art, in order to overcome the stable new defect of piperacillin sodium sulbactam sodium combination preparation, propose multiple solutions, for example Chinese patent document CN200610015440.X discloses a kind of antibiotic compound, by piperacillin sodium, sulbactam sodium Tan sodium and at least one ion chelating agent that can inhibit the formation of particles, the disadvantage is that the use of ion chelating agents, especially EDTA, can easily cause the loss of sodium, potassium, and calcium ions in bones

Method used

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  • Medicinal composition of piperacillin sodium and sulbactam sodium

Examples

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Embodiment 1

[0021] The preparation method is as follows:

[0022] Preparation of piperacillin sodium: (1) at 20-25°C, add sodium bicarbonate to piperacillin acid and keep stirring, and control the pH of the reaction solution to 5.5-6.0; (2) after the reaction, add ethanol and keep stirring After 10 minutes, irradiate with infrared rays for 3-5 minutes at the same time, and continue stirring for 30-60 minutes to obtain crystals.

[0023]Preparation of sulbactam sodium: (1) Add lysine hydrochloride to sulbactam acid acetone solution at 0-5°C, and control the pH value of the reaction solution at 6.6; (2) Add lysine hydrochloride dropwise After the completion, the temperature of the reaction solution is raised to 10-25 degrees Celsius, and the sodium bicarbonate solution is added to the sulbactamic acid acetone solution, and the pH value of the reaction solution is controlled at 6.7; (3) After the reaction is completed and filtered, it is divided into three stages. In the first stage, contro...

Embodiment 2

[0027] Piperacillin sodium and sulbactam sodium were prepared by the same process as in Example 1, except that the weight ratios of piperacillin sodium and sulbactam sodium were different during powder mixing, as shown in Table 1.

Embodiment 3

[0029] Piperacillin sodium and sulbactam sodium were prepared by the same process as in Example 1, except that the weight ratios of piperacillin sodium and sulbactam sodium were different during powder mixing, as shown in Table 1.

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Abstract

The invention discloses a medicinal composition of piperacillin sodium and sulbactam sodium. The medicinal composition comprises the following components in parts by weight: 2-4 parts of piperacillin sodium and 1 part of sulbactam sodium with specific rotation being from +230 degrees to +235 degrees. The medicinal composition disclosed by the invention has the advantages that the sulbactam sodium with the specific rotation being from +230 degrees to +235 degrees is prepared by optimizing a preparation process of the sulbactam sodium; by optimization of the preparation process of the piperacillin sodium, the stability of the medicinal composition is favorably improved and the use is safer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of piperacillin sodium and sulbactam sodium. Background technique [0002] Piperacillin sodium is a broad-spectrum penicillin antibiotic, which mainly plays a bactericidal effect by interfering with the synthesis of bacterial cell walls. -Drug resistance due to hydrolysis by lactamase; sulbactam sodium has no antibacterial activity against other bacteria except for Neisseriaceae and Acinetobacter, but sulbactam sodium is resistant to β-lactam antibiotics strains Most important β-lactamases are irreversibly inhibited. Sulbactam sodium can prevent drug-resistant bacteria from destroying penicillins and cephalosporins antibiotics, and sulbactam sodium has obvious synergistic effects with penicillins and cephalosporins antibiotics. [0003] The combined preparation of piperacillin sodium and sulbactam sodium has a large clinical dosage, defini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K31/43A61P31/04C07D499/86C07D499/16C07D499/18
CPCA61K31/496C07D499/86A61K31/43C07B2200/07C07D499/16C07D499/18A61K2300/00
Inventor 郁蕾李穿江李家成
Owner SICHUAN PHARMA
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