Pharmaceutical composition containing beta-lactamase restrainer and piperacillin sodium with steady content and preparation method thereof

Abstract

The invention provides a stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium and the preparation method thereof. The drug compound consists of piperacillin sodium, Beta-lactamases inhibitors and pH-value regulators with the weight proportion of 1 to 100:1:0.001 to 2. Diluted and delivered in any proportion with conventional clinical transfusions, the drug compound can have a stable piperacillin sodium content, dissolve rapidly, generate no crystallization or degradation products and receive no effect from the temperature. The preparation method of the stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium has simple preparing method and high efficiency and is fit for a large-scale industrial production.

Description

technical field

[0001] The invention relates to a pharmaceutical composition with stable content of active ingredients. Specifically, it relates to a drug that can maintain stable content of piperacillin sodium when it is diluted with all clinical routine infusion solutions in any ratio, and dissolves quickly, does not produce crystals and degradation products, and is not affected by temperature. A pharmaceutical composition comprising a beta-lactamase inhibitor and piperacillin sodium. Background technique

[0002] Piperacillin sodium is a semi-synthetic penicillin antibiotic with broad antibacterial spectrum and few side effects, and is widely used in clinic. However, in the course of clinical application, it was found that the compound preparation containing piperacillin sodium and β-lactamase inhibitor dissolved in the infusion would often appear turbid, and the content of piperacillin sodium decreased, so the use was terminated. Especially in winter and spring in the ...

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