Compound injection composed of probenecid and penicillin antibiotic

A probenecid sodium and compound formulation technology, applied in the directions of antibacterial drugs, active ingredients of heterocyclic compounds, active ingredients of anhydrides/acids/halides, etc., can solve the problems such as the lack of probenecid

Inactive Publication Date: 2006-08-09
吴晓辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, except for the oral compound preparation composed of probenecid and ampicillin, there is no compound preparation of probenecid and other β-lactam antibiotics (including oral compound preparations and compound prescriptions).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Amoxicillin sodium and probenecid sodium were mixed at a ratio of 3:1 (on a dry basis) to prepare a compound powder injection through a conventional process under conditions consistent with the compound prescription.

Embodiment 2

[0039] Example 2: Piperacillin sodium and probenecid sodium were mixed at a ratio of 5:1 (on a dry basis) through conventional techniques under conditions consistent with compound prescription preparations to prepare compound powder injections.

Embodiment 3

[0040] Example 3: Amoxicillin sodium and probenecid sodium were mixed in a ratio of 3:1 (on a dry basis) through a conventional process under conditions consistent with the compound formulation to prepare a compound freeze-dried injection.

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PUM

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Abstract

The present invention relates to a compound injection preparation formed from probenecid sodium and benzylpenicillin antibiotics, belonging to the field of chemical pharmaceutical technology. The benzylpenicillin antibiotics include amoxicillin sodium and piperacillin sodium. The amoxicillin sodium and piperacillin sodium are mixed according to ratio of 1:3 and 1:5 through a conventional preparation process.

Description

Technical field: [0001] The invention relates to a compound prescription preparation composed of probenecid sodium and penicillin antibiotics, in particular to a novel compound prescription preparation composed of probenecid sodium, amoxicillin sodium and piperacillin sodium, which belongs to the field of chemical pharmacy. Background technique: [0002] Probenecid can competitively inhibit the secretion of many β-lactam antibiotics in renal tubules, prolong the elimination half-life (t1 / 2β) of these antibiotics, increase the area under the curve (AUC), and increase the level of blood drug concentration , so that their blood concentration exceeds the minimum inhibitory concentration (MIC) of the corresponding bacteria significantly prolongs (prolonged T>MIC), thereby increasing their curative effect. At present, except for the oral compound preparation composed of probenecid and ampicillin, there is no compound preparation (including oral compound preparation and compound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K31/43A61K31/431A61K9/19A61P31/04
Inventor 吴晓辉
Owner 吴晓辉
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