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30 results about "Mycinamicins" patented technology
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Mycinamicins, novel macrolide antibiotics were obtained from the culture broth of Micromonospora grisseorubida sp. nov. Isolation of five components, mycinamicins I, II, III, IV and V, was accomplished by silica gel adsorption or partition chromatography.
Rifamycin analogs and uses thereof
InactiveUS20050043298A1Improve permeabilityGood curative effectAntibacterial agentsBiocideMycinamicinsPharmacology
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′-and / or 6′ halo and / or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety.
Owner:ACTIVBIOTICS PHARMA
Rifamycin analogs and uses thereof
InactiveUS20050137189A1Improve permeabilityGood curative effectAntibacterial agentsBiocideBenzeneAcetylation
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, and / or various fused ring systems with the benzene ring at the 4′,5′ or 5′,6′ positions.
Owner:ACTIVBIOTICS PHARMA
Ningnanmycin composition and preparation method thereof
ActiveCN101978827ADelay drug resistanceImprove product qualityBiocideMicroorganism based processesDiseasePlant virus
The invention provides a pesticide composition containing ningnanmycin. The pesticide composition also contains two ningnanmycin analogs which can effectively prevent and control plant virus diseases, fungus diseases and bacteria diseases separately and together. In addition, the invention also provides a preparation method for the pesticide composition, a prepared pesticide preparation and application of the ningnanmycin analogs and the like.
Owner:德强生物股份有限公司
Improved penicillin antibiotic aptamer without fixed point target substance and application thereof
ActiveCN103387991AEasy to fixEasy to operateColor/spectral properties measurementsDNA/RNA fragmentationElutionMISCELLANEOUS ANTIBIOTICS
The invention discloses a penicillin antibiotic aptamer obtained by the screening technology for an improved aptamer without a fixed point target substance in the field of screening a penicillin antibiotic aptamer without a fixed point target substance, and an application thereof. The unfixed nucleic acid is eluted through a fixed oligonucleotide library; the parent nucleus 6-APA (6-aminopenicillanic acid) of the penicillin antibiotic is added in positive screening to act on the fixed nucleic acid; after eluting the nucleic acid molecules which can be combined with 6-APA, PCR (polymerase chain reaction) amplification is directly performed for next screening; and other antibiotics are added in negative screening, and the nucleic acid molecules in non-specific binding with the penicillin antibiotics are removed by elution. Through multiple rounds of positive and negative screening, 10 nucleic acid aptamers with high specificity and strong affinity with 6-APA are obtained; and the nucleic acid aptamer with a stable secondary structure is selected for developing a nucleic acid aptamer sensor for detecting 6-APA.
Owner:SHANGHAI JIAO TONG UNIV
Method for detecting antibiotic residues in water body environment based on solid phase extraction technology and liquid chromatography tandem mass spectrometry technology
PendingCN110726792AReduce signal to noise ratioGood peak shapeComponent separationMycinamicinsMacrolide resistance
The invention provides a method for detecting antibiotic residues in a water body environment based on the solid phase extraction technology and the liquid chromatography tandem mass spectrometry technology. In terms of detection effect, the signal-to-noise ratio is improved by optimizing the mass spectrum conditions, the peak shape is improved, and a lower detection limit of the method of a sample reaches 0.08 to 9.37ng / L; in terms of sample pretreatment, only 50mL water sample is required, thereby shortening the pretreatment time; in terms of the number of antibiotics and the detection time,42 kinds of antibiotics in 5 major categories, such as fluoroquinolones, sulfonamides, macrolides, chloramphenicols and lincomamides, can be separated and detected at one time just within 12min by optimizing the chromatographic conditions.
Owner:ZHEJIANG UNIV OF TECH +1
Method for separation and enrichment of penicillin antibiotics in water
InactiveCN103344715AReduce usageHigh enrichment factorComponent separationMycinamicinsSolid phase extraction
The invention relates to a method for separation and enrichment of penicillin antibiotics in water. The method comprises the following steps of adjusting a pH value of a water sample to 2-4 by an acid; filtering the water sample to obtain a pretreated water sample; activating an HLB solid-phase extraction column by acetone, methanol and a formic acid aqueous solution containing ammonium acetate successively; adding ultrapure water to keep a resin in the HLB solid phase extraction column in an activated state; passing the water sample through the column; drying the HLB solid-phase extraction column under the protection of nitrogen after enrichment is finished; eluting with an eluent; collecting the eluent; blow-drying under a nitrogen flow; adding acetonitrile to dissolve residual materials for detection; and detecting the concentrations of penicillin antibiotics quantitatively. The method is advantageous in that the pretreatment of the water sample is environment-friendly; and the method can be operated easily, has high enrichment coefficient, low detection limit and good repeatability, and can analyze the content of two trace penicillin antibiotics in a water environment rapidly and accurately.
Owner:CHINESE RES ACAD OF ENVIRONMENTAL SCI
Spectinamides as anti-tuberculosis agents
ActiveCN102548552AAntibacterial agentsOrganic active ingredientsTreating tuberculosisPolymicrobial Infections
Novel 3'-deoxy-3'-acylaminospectinomycin compounds are described. Also described are methods of using the 3'-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.
Owner:UNIV OF TENNESSEE RES FOUND
Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same
InactiveUS7125844B2Growth of microbeGrowth inhibitionAntibacterial agentsBiocideMicroorganismAntibiotic Y
The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.
Owner:BIOWEST THERAPEUTICS
Pharmaceutic preparation for livestock and application thereof
ActiveCN102805866AReduce usageIncreased sensitivityAntibacterial agentsOrganic active ingredientsBiotechnologyMycinamicins
The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.
Owner:HENAN XINZHENGHAO BIO ENG
Technology for processing wastewater generated in lincomycin antibiotic production
InactiveCN110981116AImprove B/C ratioImprove dehydration effectWater contaminantsTreatment with aerobic and anaerobic processesMycinamicinsActivated carbon filtration
The invention relates to a technology for processing wastewater generated in lincomycin antibiotic production. Acidic anaerobic bacteria can degrade biologically degradation-resistant polymer organicsubstances into biologically degradable micromolecular organic substances; the B / C ratio of wastewater can be increased to 0.26-0.30; aerobic bacteria can degrade biologically degradable micromolecular organic substances in wastewater into inorganic substances such as CO2, H2O, etc.; thus COD can be effectively removed; through oxidation of ozone, most of residual organic substances can be oxidized and decomposed into inorganic substances; then the wastewater can be filtered by active carbon so as to remove organic substances and inorganic substances such as heavy metals, ammonia nitrogen, etc. in wastewater through filtering and adsorption; and the COD of effluent is less than 100 mg / L. The provided technology can effectively process wastewater generated in lincomycin antibiotic production; the processing effect is good, the water quality of the effluent is stable; the COD concentration of the effluent is smaller than 100 mg / L, and the operation cost is reasonable.
Owner:YANGZHOU UNIV
ELISA detection method for penicillins antibiotic residue
The invention provides a multi-residual enzyme-linked immunoassay method used for antibiotics such as penicillins and the like, belonging to the technical field of immunoassay. The method obtains a polyclonal antibody by utilizing immunogen immunity synthesized by 6-amino penicillanic acid; the antibiotics such as the penicillins and the like are used as standard products and the conjugate of the 6-amino penicillanic acid and OVA is used as coating antigen, thus establishing the indirect ELISA method of antibiotics such as penicillins and the like in animal foods. The method provides a quick and high-efficiency detection means for the residual detection of the antibiotics such as penicillins and the like in the animal foods; as the polyclonal antibody is adopted, the expense is lower and the stability and repeatability are better; furthermore, the method has the advantages of simple predisposal, high sensitiveness, high precision and the like.
Owner:JIANGNAN UNIV
Bovine-derived bacillus cereus and application thereof
ActiveCN111733094AReduce disease lossesShorten diagnostic timeBacteriaMicrobiological testing/measurementMycinamicinsDisease
The invention discloses bovine-derived bacillus cereus M001. The bovine-derived bacillus cereus M001 is collected in the China General Microbiological Culture Collection Center. The strain is separated from blood of cattle suffering from the sudden death disease; and the bacterial colony is a wax drop-like bacterial colony with red center, grey white periphery and irregular periphery. The strain can be seen by microscopic examination, two ends of the strain are flush, the size of the strain is about 1.0x6.0 [mu]m, and the strain is mostly arranged in a long chain mode and is Gram-positive bacteria. After special staining, the strain is placed under a microscope for observation, and parasporal crystals are not observed; a 16SrDNA sequence is as shown in a sequence table; the strain is sensitive to clindamycin and gentamicin drugs, is moderately sensitive to erythromycin, minocycline and other drugs, and is resistant to ceftazidime, aztreonam and other drugs; and the strain has pathogenicity and lethality for the cattle. The strain can be used as a bovine epidemic disease quarantine control sample or a bovine epidemic disease prevention vaccine.
Owner:INNER MONGOLIA UNIV FOR THE NATITIES
Ningnanmycin composition and preparation method thereof
ActiveCN101978827BDelay drug resistanceImprove product qualityBiocideMicroorganism based processesMycinamicinsPlant virus
The invention provides a pesticide composition containing ningnanmycin. The pesticide composition also contains two ningnanmycin analogs which can effectively prevent and control plant virus diseases, fungus diseases and bacteria diseases separately and together. In addition, the invention also provides a preparation method for the pesticide composition, a prepared pesticide preparation and application of the ningnanmycin analogs and the like.
Owner:德强生物股份有限公司
Preparation method of penicillin antibiotic impurity
PendingCN111197064AEasy to operateShort reaction timeOrganic chemistryFermentationFlucloxacillinMycinamicins
The invention relates to a preparation method of a penicillin antibiotic impurity. The penicillin antibiotic impurity has a structure represented by formula (I), and in the formula (I), R represents side chains of penicillin, mezlocillin, piperacillin sodium and flucloxacillin. The method comprises the following steps: (1) mixing penicillin antibiotic, beta-lactamase and water; (2) controlling thetemperature to be 37 DEG C or below; (3) purifying by preparative chromatography, and concentrating; and (3) mixing and reacting with an alcohol solvent. The method is simple to operate and short inreaction time, the purity of the product is 90% or above, and the product can be directly used as a reference substance to qualitatively and quantitatively research penicillin antibiotics, so that theproduct quality is effectively controlled.
Owner:CHONGQING MEDICAL & PHARMA COLLEGE
Yuanjiang mycin analogue as well as preparation method and application thereof
PendingCN112920197AExcellent anti-tumor performanceReduce the cost of separation and purificationOrganic chemistryMicroorganism based processesMycinamicinsStreptomyces
The invention belongs to the technical field of biological medicines, and particularly relates to a Yuanjiang mycin confirmation method, a preparation method and an anti-tumor application of Yuanjiang mycin. The structural formula of the Yuanjiang mycin analogue is shown in the specification. According to the invention, through fermentation culture of Streptomyces sp.CB03234-S, then design of special separation and purification steps, and adoption of specially designed gradient elution and a special eluent, YJM A and YJM B with the purity exceeding 97% can be obtained, and the establishment of the preparation process greatly reduces the separation and purification cost of Yuanjiang mycin. The anti-tumor performance of the YJM A disclosed by the invention is far better than that of similar compounds.
Owner:HAYAO CIHANG PHARM CO LTD +2
Spectinomycinamide as an anti-tuberculosis agent
The present application describes novel 3'-deoxy-3'-acylamino spectinomycin compounds. Also described are methods of using 3'-deoxy-3-acylamino spectinomycin and other spectinomycin analogs for the treatment of tuberculosis and for the treatment of microbial infections.
Owner:UNIV OF TENNESSEE RES FOUND
Pharmaceutic preparation for livestock and application thereof
ActiveCN102805866BReduce usageIncreased sensitivityAntibacterial agentsOrganic active ingredientsBiotechnologyMycinamicins
The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.
Owner:HENAN XINZHENGHAO BIO ENG
Spherical crystal of spiramycin antibiotics and preparation method thereof
The invention relates to a preparation method of a spiramycin antibiotic spherical crystal. The preparation method comprises the following steps: mixing a good solvent dissolved with spiramycin antibiotics with a poor solvent, enabling the mixed solution to form an emulsion-like system under the emulsifying and stirring effects of auxiliary materials, gradually separating out the spiramycin antibiotics along with volatilization of the good solvent, and forming the spherical crystal. Compared with the prior art, the spiramycin antibiotic spherical crystal product provided by the invention has the mean particle size D43 of 200-400 microns, and the uniformity is 0.2 or higher.
Owner:EAST CHINA UNIV OF SCI & TECH
Application of glutathione reductase to binding of penicillin antibiotics
InactiveCN104560903AMicrobiological testing/measurementOxidoreductasesMycinamicinsGlutathione reductase
The invention belongs to the field of biotechnology and particularly discloses an application of glutathione reductase to binding of penicillin antibiotics. A sequence of the glutathione reductase is as shown in SEQ ID NO:1. The glutathione reductase ETAE_3367 is a new penicillin antibiotic binding protein and can be effectively applied to the detection of the penicillin antibiotics, the preparation of detection reagents and further research on effects and drug resistance mechanisms of the penicillin antibiotics.
Owner:SUN YAT SEN UNIV
A method for removing residual penicillin antibiotics in biomedical waste residue
ActiveCN108653971BFast and efficient removal processIn line with the concept of green, coordinated and sustainable developmentChemical protectionMycinamicinsBiochemical engineering
The invention relates to a method for removing residual penicillin antibiotics in biomedical waste residues, comprising the following steps: (1) adding an activator to the biomedical waste residues containing penicillin antibiotics, and obtaining waste residue slurry after slurry mixing and dispersion; 2) Adding a catalyst and an oxidizing agent to the waste residue slurry obtained in step (1), and performing a degradation reaction to complete the removal of the residual penicillin antibiotics in the biomedical waste residue. Compared with the prior art, the present invention can quickly and efficiently remove more than 99% of residual antibiotics, and this method degrades penicillin antibiotics into other non-toxic and non-medicinal substances, and the waste residue obtained from the treatment is solid, which is convenient for storage It can be used for the production of fertilizers and soil conditioners, which conforms to the concept of green, coordinated and sustainable development, and meets the requirements of energy conservation and environmental protection advocated by the state.
Owner:SHANGHAI RES INST OF CHEM IND
A Strain of Chlamydocetes sp. sp. and its Screening and Application
The invention relates to a strain of chlamydocetes sporoconiae and its screening and application, and belongs to the technical field of nematicidal biological resources and microbial strains. The Chlamydobacterium chlamydosporia (Pochonia chlamydosporia) YMF 1.00613 was deposited on May 10, 2010 in the General Microorganism Center of China Committee for the Collection of Microorganisms, with the preservation number CGMCC No.3806. The screening step of the bacterial strain includes: separation and purification of the bacterial strain, and screening of secondary metabolites of aurovertins produced by the bacterial strain. The application of the chlamydobacterium Pochonia chlamydosporia YMF 1.00613 strain of the invention in the preparation of agricultural insecticides for preventing and controlling plant pathogenic nematodes and the fermentation production of biological pesticides. The invention has the effect of significantly suppressing the reproduction of pests and the number of offspring populations. The strain PDB fermentation broth and its secondary metabolites, mainly composed of auromycin compounds, have the ability to kill nematodes, and the nematicide activity can reach more than 90% under experimental conditions, and can be used as biologically active substances such as nematicides and biological pesticides fermentation production.
Owner:YUNNAN UNIV
A kind of friendly mycin compound and its preparation method and application
ActiveCN109824746BFill in research gapsSolve a rare problemSugar derivativesDigestive systemMycinamicinsPharmaceutical drug
The invention discloses an amicetin compound. The structural formula is shown in the formula I which is shown in the description, wherien R1 is H or shown in the description; R2 is H or OH; R3 is CH3or CH2CH3 or is shown in the description. The amicetin compound has the colon cancer resisting activity. The invention further discloses a preparation method of the amicetin compound. The preparationmethod comprises the steps that rice is fermented by marine actinomycete rice to obtain extracts, and the extracts are separated and purified by using the chromatographic technique to obtain the amicetin compound. Operation and implementation are facilitated. The invention further discloses application of the amicetin compound in preparing a drug for inhibiting colon cancer.
Owner:浙江美新控股有限公司
Application of a Streptomyces and its Metabolites Penicillin Compounds in Anti-kidney Cancer
The invention discloses the application of a streptomyces and its metabolites fenopterine compounds in anti-kidney cancer. The Streptomyces sp.HBERC-58855 of the present invention is preserved in the China Center for Type Culture Collection, the preservation address is China. Wuhan. Wuhan University, the preservation date is April 20, 2017, and the preservation number is CCTCC NO: M 2017186. The nucleotide sequence of 16sRNA of Streptomyces sp. HBERC-58855 of the present invention is shown in SEQ ID NO:1. For the first time, the present invention fermented and extracted from Streptomyces sp. HBERC-58855 to obtain piericidin compounds Piericidin A, Piericidin A2, Piericidin C2, IT-143-A, IT-143-B and Piericidin s3a. And applying it to the preparation of anti-kidney cancer drugs provides candidate compounds for the development of new anti-kidney cancer drugs, and is of great significance to the development of marine microbial drug resources.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Penicillin-binding protein Bt-pbp2X and application thereof
ActiveCN106085982AEasy to handleLowering techniqueBacteriaMicrobiological testing/measurementPenicillin bindingPenicillin K
The invention provides a novel penicillin-binding protein Bt-pbp2X and encoding genes thereof. The protein has an amino acid sequence shown in SEQ ID No.2, or has the amino acid sequence obtained through substitution, deletion and / or increase of one or more amino acids from the amino acid sequence shown in SEQ ID No.2 with equal activity. The protein can be used for preparing a penicillin antibiotic detection reagent and can be applied to rapid detection of penicillin antibiotic residues. A complex instrument is not needed, the sample pretreatment process is very simple, specific requirements are made for technological and knowledge level of detection people, and the protein is very suitable for spot rapid detection.
Owner:岩璟生物科技武汉有限公司
Improved penicillin antibiotic aptamer without fixed point target substance and its application
ActiveCN103387991BEasy to fixEasy to operateColor/spectral properties measurementsDNA/RNA fragmentationAptamerMycinamicins
Owner:SHANGHAI JIAOTONG UNIV
Application of rifamycin antibiotics in preparation of drugs against yellow fever virus infections
The invention relates to the technical field of medicine, and relates to an application of rifamycin antibiotics in the preparation of drugs against yellow fever virus infections. The rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, and include a variety of broad-spectrum antibiotics of the rifamycin family, the curative effect for treating bacterial infections is sure, side effects are low, and the safety is good. The application of the rifamycin antibiotics in the drugs against yellow fever virus infections is reported for the first time in the world.
Owner:THE NAVAL MEDICAL UNIV OF PLA
A kind of pyridone tetramycin and preparation method thereof and application in the preparation of anticancer drugs
The present invention discloses a pyridonone powder butterin and its preparation methods and the application of anticancer drugs.Piericidin N, pyrine powder butterflycol -butterflycin, which is the invention, is as shown in the formula (i) as shown in the formula (i).The present invention revealed that Piericidin N has obvious selective inhibitory activity on HL‑60, a human early younger granular leukemia cell HL‑60. This type of pyrine powder can be used to prepare a special anti -leukemia drug.Therefore, the present invention provides alternative compounds for the development of new anti -white hem diseased drugs, which is of great significance to the development of my country's microbial drug resources.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI +1
Application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection drugs
The invention relates to the technical field of medicine, and relates to the application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection medicines. Rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, including a variety of broad-spectrum antibiotics of the rifamycin family, which are effective in treating bacterial infections, with low side effects and good safety. . This patent reports the application of rifamycin antibiotics in anti-yellow fever virus infection drugs, which is the first report in the world.
Owner:THE NAVAL MEDICAL UNIV OF PLA
Dab9 DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME
The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.
Owner:BIOWEST THERAPEUTICS
Mycoplasma culture identification and medicine sensitive detection plate and method for identifying truth of result of C+ hole
InactiveCN102676378ABioreactor/fermenter combinationsBiological substance pretreatmentsAntifungalMycinamicins
The invention discloses a mycoplasma medicine sensitive test plate, which is provided with an identification area on the basis of the common medicine sensitive test plate and can identify the truth of a result of a C+ hole while performing mycoplasma culture and medicine sensitive tests. The invention also discloses a method for identifying the truth of the result of a mycoplasma positive control hole (C+ hole). According to the method, a culture result property identifying area is increased on the basis of the mycoplasma medicine sensitive test plate, a broad-spectrum antibiotic medicine of non anti-mycoplasma microorganisms is enveloped in the identification area, and sundry bacteria which easily cause false positive and false negative in the positive control hole (C+ hole) are inhibited from growing or directly inactivated, so that a culture result is identified; and the medicine enveloped can be one or more of beta-lactam medicines, sulfanilamide medicines, rifamycins, vancomycin, antifungal medicines and the like.
Owner:武汉菁华时间科技有限公司
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