13 results about "Mycinamicins" patented technology

The present invention relates to novel rufamycin analogs that target the ClpC1 protease. The compounds of the present invention have antibacterial activity, e.g., with anti-tuberculosis properties, and are useful in the treatment of e.g. Tuberculosis.

The invention belongs to the field of biological pharmacy, and particularly relates to a chalcanthicidin compound and application thereof. The invention discloses a chalcanthicidin compound which is separated from a secondary metabolite of marine actinomycetes Streptomyces sp. KCB-132 (marine actinomycetes sp. KCB-132). Pharmacological activity experiments show that the compound has a moderate inhibition effect on ESKAPE pathogenic bacteria with multiple drug resistance, such as enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii and escherichia coli. Therefore, the compound has the potential of being developed into a novel antibacterial agent.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application has the use in preparing the product for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

The invention discloses a solid-phase extraction process method for detecting veterinary drug residues in an animal-derived sample, and belongs to the technical field of analysis of harmful residues in food. The method comprises the steps of sample pretreatment, solid-phase extraction column activation balance, sample loading, multi-stage washing and core collaborative elution. Especially, core collaborative elution adopts a collaborative elution method combining three-stage pH gradient elution and two-time competitive acetone pulse injection. The method comprises the following steps: firstly, eluting sulfonamides and quinolones under an acidic condition; then injecting acetone to competitively remove phospholipid; then, the tetracycline and macrolide drugs are eluted under the neutral condition; injecting acetone again for deep purification; and finally, eluting the chloramphenicol medicine under an alkaline condition. According to the method, the problem that the recovery rate and the purification degree are difficult to consider when multiple types of veterinary drug residues in the egg high-phospholipid complex matrix are synchronously detected is effectively solved, and the accuracy, the sensitivity and the reproducibility of subsequent LC-MS / MS analysis are remarkably improved.

The application belongs to the technical field of medicine, and discloses a kind of amidine compound and its preparation method and application in treating bacterial infection, specifically discloses a kind of amidine compound and its pharmaceutically acceptable salt and preparation method and application in treating bacterial infection as shown in the following general formula (I).The amidine compound of the application is used in the preparation of products for enhancing the activity of other antibiotics.The antibiotics include macrolide drugs, pleuromutilin drugs, quinolone drugs, rifamycin drugs, dihydrofolate reductase inhibitor drugs, oxazolidinone drugs, lincosamide drugs, capreomycin drugs, mupirocin drugs and fusidic acid drugs.

To provide a novel antimicrobial product that enables the management of animal diseases while reducing reliance on conventional antibiotics. [Solution] The present invention relates to an antimicrobial composition comprising an extract of a coffee composition and an antibiotic, and to the use of the antimicrobial composition in the manufacture of antimicrobial drugs. The extract of the coffee composition comprises a solid component and water, the solid component comprising coffee beans and auxiliary materials. The antibiotic is selected from the group consisting of penicillin antibiotics, cephalosporin antibiotics, fluoroquinolone antibiotics, tetracycline antibiotics, chloramphenicol antibiotics, aminoglycoside antibiotics and combinations thereof, and the weight ratio of the coffee composition to the antibiotic is from 1.5:1 to 25000:1. The antimicrobial composition of the present invention can exhibit a superior antibacterial effect compared to the use of antibiotics alone, and this antibacterial effect can also be exerted against drug-resistant bacteria.

The present invention concerns antibody-conjugates which are especially suitable for the targeting of PTK7-expressing cells, in particular tumour cells. The antibody-conjugates according to the invention have structure (1):Herein, AB is an antibody capable of targeting PTK7-expressing tumours; L is a linker that links Z to D; Z is a connecting group; L6 is -GlcNAc(Fuc)w-(G)j-S-(L7)w′-, wherein G is a monosaccharide, j is an integer in the range of 0-10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine and Fuc is fucose, w is 0 or 1, w′ is 0, 1 or 2 and L7 is —N(H)C(O)CH2—, —N(H)C(O)CF2— or —CH2—; D is selected from the group consisting of anthracyclines, camptothecins, tubulysins, enediynes, amanitins, duocarmycins, maytansinoids, auristatins, eribulins, BCL-XL inhibitors, hemiasterlins, KSP inhibitors, TLR agonists, indolinobenzodiazepine dimers or pyrrolobenzodiazepine dimers (PBDs), and analogues or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further concerns a method for preparing the antibody-conjugates of structure (1) and application of the antibody-conjugates of structure (1).

The invention belongs to the technical field of plant protection, and discloses application of novomycin and a composition thereof in mite killing. It is found for the first time that the novomycin compound has an acaricidal effect, when the novomycin compound is combined with antibiotic insecticidal and acaricidal agents for use, the novomycin compound has a synergistic effect, the activity of acaricidal drugs on drug-resistant acarid can be remarkably improved, the drug resistance of existing acaricidal agents is delayed, the use of the acaricidal agents is reduced, and the novomycin compound can be used for preventing and treating agricultural acarid harm and has a broad application prospect. The method has a good application prospect in plant protection.

The invention discloses a beta-substituted phosphinamine mycin analogue as well as a preparation method and application thereof, and belongs to the field of plant protection. The molecular structure of the beta-substituted phosphinamine mycin analogue is formed by connecting two pharmacophores of phosphonic acid (ester) and hydroximic acid of phosphinamine mycin through a beta-substituent-containing propyl chain, the beta-substituted phosphinamine mycin analogue is obtained through beta-substituent structure optimization, and the structural general formula of the beta-substituted phosphinamine mycin analogue is as shown in formula (I). The compound acts on 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) in a 2-C-methyl-D-erythritol 4-phosphate path (MEP), is a herbicidal active compound with a new action mode, is high in herbicidal activity and safe to crops, and can be applied as a novel herbicide. Formula (I)