To provide a novel
antimicrobial product that enables the management of animal diseases while reducing reliance on conventional
antibiotics. [Solution] The present invention relates to an
antimicrobial composition comprising an extract of a coffee composition and an antibiotic, and to the use of the
antimicrobial composition in the manufacture of antimicrobial drugs. The extract of the coffee composition comprises a
solid component and water, the
solid component comprising coffee beans and auxiliary materials. The antibiotic is selected from the group consisting of
penicillin antibiotics,
cephalosporin antibiotics, fluoroquinolone antibiotics,
tetracycline antibiotics,
chloramphenicol antibiotics,
aminoglycoside antibiotics and combinations thereof, and the weight ratio of the coffee composition to the antibiotic is from 1.5:1 to 25000:1. The antimicrobial composition of the present invention can exhibit a superior
antibacterial effect compared to the use of antibiotics alone, and this
antibacterial effect can also be exerted against
drug-
resistant bacteria.