30 results about "Mycinamicins" patented technology

The invention discloses a penicillin antibiotic aptamer obtained by the screening technology for an improved aptamer without a fixed point target substance in the field of screening a penicillin antibiotic aptamer without a fixed point target substance, and an application thereof. The unfixed nucleic acid is eluted through a fixed oligonucleotide library; the parent nucleus 6-APA (6-aminopenicillanic acid) of the penicillin antibiotic is added in positive screening to act on the fixed nucleic acid; after eluting the nucleic acid molecules which can be combined with 6-APA, PCR (polymerase chain reaction) amplification is directly performed for next screening; and other antibiotics are added in negative screening, and the nucleic acid molecules in non-specific binding with the penicillin antibiotics are removed by elution. Through multiple rounds of positive and negative screening, 10 nucleic acid aptamers with high specificity and strong affinity with 6-APA are obtained; and the nucleic acid aptamer with a stable secondary structure is selected for developing a nucleic acid aptamer sensor for detecting 6-APA.

The invention relates to a technology for processing wastewater generated in lincomycin antibiotic production. Acidic anaerobic bacteria can degrade biologically degradation-resistant polymer organicsubstances into biologically degradable micromolecular organic substances; the B / C ratio of wastewater can be increased to 0.26-0.30; aerobic bacteria can degrade biologically degradable micromolecular organic substances in wastewater into inorganic substances such as CO2, H2O, etc.; thus COD can be effectively removed; through oxidation of ozone, most of residual organic substances can be oxidized and decomposed into inorganic substances; then the wastewater can be filtered by active carbon so as to remove organic substances and inorganic substances such as heavy metals, ammonia nitrogen, etc. in wastewater through filtering and adsorption; and the COD of effluent is less than 100 mg / L. The provided technology can effectively process wastewater generated in lincomycin antibiotic production; the processing effect is good, the water quality of the effluent is stable; the COD concentration of the effluent is smaller than 100 mg / L, and the operation cost is reasonable.

The invention provides a multi-residual enzyme-linked immunoassay method used for antibiotics such as penicillins and the like, belonging to the technical field of immunoassay. The method obtains a polyclonal antibody by utilizing immunogen immunity synthesized by 6-amino penicillanic acid; the antibiotics such as the penicillins and the like are used as standard products and the conjugate of the 6-amino penicillanic acid and OVA is used as coating antigen, thus establishing the indirect ELISA method of antibiotics such as penicillins and the like in animal foods. The method provides a quick and high-efficiency detection means for the residual detection of the antibiotics such as penicillins and the like in the animal foods; as the polyclonal antibody is adopted, the expense is lower and the stability and repeatability are better; furthermore, the method has the advantages of simple predisposal, high sensitiveness, high precision and the like.

The invention provides a pesticide composition containing ningnanmycin. The pesticide composition also contains two ningnanmycin analogs which can effectively prevent and control plant virus diseases, fungus diseases and bacteria diseases separately and together. In addition, the invention also provides a preparation method for the pesticide composition, a prepared pesticide preparation and application of the ningnanmycin analogs and the like.

The present application describes novel 3'-deoxy-3'-acylamino spectinomycin compounds. Also described are methods of using 3'-deoxy-3-acylamino spectinomycin and other spectinomycin analogs for the treatment of tuberculosis and for the treatment of microbial infections.

The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.

The invention relates to a preparation method of a spiramycin antibiotic spherical crystal. The preparation method comprises the following steps: mixing a good solvent dissolved with spiramycin antibiotics with a poor solvent, enabling the mixed solution to form an emulsion-like system under the emulsifying and stirring effects of auxiliary materials, gradually separating out the spiramycin antibiotics along with volatilization of the good solvent, and forming the spherical crystal. Compared with the prior art, the spiramycin antibiotic spherical crystal product provided by the invention has the mean particle size D43 of 200-400 microns, and the uniformity is 0.2 or higher.

The invention relates to a method for removing residual penicillin antibiotics in biomedical waste residues, comprising the following steps: (1) adding an activator to the biomedical waste residues containing penicillin antibiotics, and obtaining waste residue slurry after slurry mixing and dispersion; 2) Adding a catalyst and an oxidizing agent to the waste residue slurry obtained in step (1), and performing a degradation reaction to complete the removal of the residual penicillin antibiotics in the biomedical waste residue. Compared with the prior art, the present invention can quickly and efficiently remove more than 99% of residual antibiotics, and this method degrades penicillin antibiotics into other non-toxic and non-medicinal substances, and the waste residue obtained from the treatment is solid, which is convenient for storage It can be used for the production of fertilizers and soil conditioners, which conforms to the concept of green, coordinated and sustainable development, and meets the requirements of energy conservation and environmental protection advocated by the state.

The invention relates to a strain of chlamydocetes sporoconiae and its screening and application, and belongs to the technical field of nematicidal biological resources and microbial strains. The Chlamydobacterium chlamydosporia (Pochonia chlamydosporia) YMF 1.00613 was deposited on May 10, 2010 in the General Microorganism Center of China Committee for the Collection of Microorganisms, with the preservation number CGMCC No.3806. The screening step of the bacterial strain includes: separation and purification of the bacterial strain, and screening of secondary metabolites of aurovertins produced by the bacterial strain. The application of the chlamydobacterium Pochonia chlamydosporia YMF 1.00613 strain of the invention in the preparation of agricultural insecticides for preventing and controlling plant pathogenic nematodes and the fermentation production of biological pesticides. The invention has the effect of significantly suppressing the reproduction of pests and the number of offspring populations. The strain PDB fermentation broth and its secondary metabolites, mainly composed of auromycin compounds, have the ability to kill nematodes, and the nematicide activity can reach more than 90% under experimental conditions, and can be used as biologically active substances such as nematicides and biological pesticides fermentation production.

The invention discloses an amicetin compound. The structural formula is shown in the formula I which is shown in the description, wherien R1 is H or shown in the description; R2 is H or OH; R3 is CH3or CH2CH3 or is shown in the description. The amicetin compound has the colon cancer resisting activity. The invention further discloses a preparation method of the amicetin compound. The preparationmethod comprises the steps that rice is fermented by marine actinomycete rice to obtain extracts, and the extracts are separated and purified by using the chromatographic technique to obtain the amicetin compound. Operation and implementation are facilitated. The invention further discloses application of the amicetin compound in preparing a drug for inhibiting colon cancer.

The invention discloses the application of a streptomyces and its metabolites fenopterine compounds in anti-kidney cancer. The Streptomyces sp.HBERC-58855 of the present invention is preserved in the China Center for Type Culture Collection, the preservation address is China. Wuhan. Wuhan University, the preservation date is April 20, 2017, and the preservation number is CCTCC NO: M 2017186. The nucleotide sequence of 16sRNA of Streptomyces sp. HBERC-58855 of the present invention is shown in SEQ ID NO:1. For the first time, the present invention fermented and extracted from Streptomyces sp. HBERC-58855 to obtain piericidin compounds Piericidin A, Piericidin A2, Piericidin C2, IT-143-A, IT-143-B and Piericidin s3a. And applying it to the preparation of anti-kidney cancer drugs provides candidate compounds for the development of new anti-kidney cancer drugs, and is of great significance to the development of marine microbial drug resources.

The invention discloses a penicillin antibiotic aptamer obtained by the screening technology for an improved aptamer without a fixed point target substance in the field of screening a penicillin antibiotic aptamer without a fixed point target substance, and an application thereof. The unfixed nucleic acid is eluted through a fixed oligonucleotide library; the parent nucleus 6-APA (6-aminopenicillanic acid) of the penicillin antibiotic is added in positive screening to act on the fixed nucleic acid; after eluting the nucleic acid molecules which can be combined with 6-APA, PCR (polymerase chain reaction) amplification is directly performed for next screening; and other antibiotics are added in negative screening, and the nucleic acid molecules in non-specific binding with the penicillin antibiotics are removed by elution. Through multiple rounds of positive and negative screening, 10 nucleic acid aptamers with high specificity and strong affinity with 6-APA are obtained; and the nucleic acid aptamer with a stable secondary structure is selected for developing a nucleic acid aptamer sensor for detecting 6-APA.

The present invention discloses a pyridonone powder butterin and its preparation methods and the application of anticancer drugs.Piericidin N, pyrine powder butterflycol -butterflycin, which is the invention, is as shown in the formula (i) as shown in the formula (i).The present invention revealed that Piericidin N has obvious selective inhibitory activity on HL‑60, a human early younger granular leukemia cell HL‑60. This type of pyrine powder can be used to prepare a special anti -leukemia drug.Therefore, the present invention provides alternative compounds for the development of new anti -white hem diseased drugs, which is of great significance to the development of my country's microbial drug resources.

The invention relates to the technical field of medicine, and relates to the application of rifamycin antibiotics in the preparation of anti-yellow fever virus infection medicines. Rifamycin antibiotics refer to semi-synthetic or synthetic antibiotics containing rifamycin derivatives, including a variety of broad-spectrum antibiotics of the rifamycin family, which are effective in treating bacterial infections, with low side effects and good safety. . This patent reports the application of rifamycin antibiotics in anti-yellow fever virus infection drugs, which is the first report in the world.

The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.