A kind of friendly mycin compound and its preparation method and application

A compound, the technology of yomycin, which is applied in the field of yomycin compounds and its preparation, achieves the effects of high product abundance, easy large-scale industrial cultivation, and easy operation and implementation

A compound, the technology of yomycin, which is applied in the field of yomycin compounds and its preparation, achieves the effects of high product abundance, easy large-scale industrial cultivation, and easy operation and implementation

CN109824746BActive Publication Date: 2021-02-26浙江美新控股有限公司
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  • A kind of friendly mycin compound and its preparation method and application
  • A kind of friendly mycin compound and its preparation method and application
  • A kind of friendly mycin compound and its preparation method and application

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Embodiment Construction

[0034] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed.

[0035] 1. Fermentation of compounds

[0036] The actinomycete used was the SS-A28 strain isolated from marine sediments, which was identified as Streptomyces sp.BNCC337575;

[0037] 1) Inoculate actinomycetes into 500mL Erlenmeyer flasks, each bottle is pre-filled with 250mL Gaoshi No. 1 liquid medium, and culture them in a shaker at 28°C and 180rpm for 3 days to obtain spherical actinomycetes. the seed liquid of the bacteria;

[0038] 2) Connect the seed liquid with actinomycetes in step 1) to the rice culture medium, the compositi...

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Abstract

The invention discloses an amicetin compound. The structural formula is shown in the formula I which is shown in the description, wherien R1 is H or shown in the description; R2 is H or OH; R3 is CH3or CH2CH3 or is shown in the description. The amicetin compound has the colon cancer resisting activity. The invention further discloses a preparation method of the amicetin compound. The preparationmethod comprises the steps that rice is fermented by marine actinomycete rice to obtain extracts, and the extracts are separated and purified by using the chromatographic technique to obtain the amicetin compound. Operation and implementation are facilitated. The invention further discloses application of the amicetin compound in preparing a drug for inhibiting colon cancer.

Description

technical field [0001] The invention relates to the technical field of marine microbial medicines, in particular to a friendmycin compound and its preparation method and application. Background technique [0002] In 1953, Amicetin was discovered for the first time from a soil-derived Streptomyces secondary metabolite. Researchers found that Amicetin had a good inhibitory effect on Escherichia coli and Mycobacterium tuberculosis, so it can be used as a A good potential prodrug for follow-up studies. [0003] Since then, researchers have successively discovered pyrimidine nucleoside compounds, such as cytosaminomycin, oxyplicacetin, streptcytosine, etc., from soil sources or from marine sources of Streptomyces. The structure of this nucleoside pyrimidine compound is similar, with a monosaccharide cytosine as the core, and the difference is that the substituent groups at the amino terminal of cytosine and the 4' position of the sugar ring are different. [0004] According to ...

Claims

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Application Information

Patent Timeline
26 Feb 2021
Publication
CN109824746B
IPC
C07H19/06; C07H1/06; A61P35/00; A61P1/00; C12P19/38; C12R1/465
Inventors
马忠俊; 徐成栋