Refining method for piperacillin sodium

Abstract

The invention discloses a refining method for a piperacillin sodium crude product, wherein the method is mainly a method for removing polymers in the crude product. The method is performed according to the following steps: heating a piperacillin sodium crude product, and dissolving in water and DMSO; carrying out a treatment with active carbon; filtering; adding acetone in a dropwise manner; cooling; carrying out thermal insulation crystallization; and filtering to obtain the piperacillin sodium refined product. Compared with the polymer removing method and other methods reported in traditional literatures, the method of the present invention has characteristics of simple operation, low production cost, and high finished product purity, and can be used for industrial purification production of piperacillin sodium crude products, wherein the method reported in the traditional literatures adopts an ion exchange manner.

Description

technical field

[0001] The invention relates to a refining method of crude piperacillin sodium, in particular to a method for removing polymers. technical background

[0002] Piperacillin sodium (piperacilin sodium), the chemical name is (2S, 5R, 6R)-6-[2-(2R)-4-(4-ethyl-2,3-dioxo-1-piperazinyl) ) Sodium formamido-2-phenylacetamido] penicillanate. Structural formula:

[0003]

[0004] This product is developed by Japan Toyama Chemical Industry Co., Ltd. It is clinically applicable to sepsis caused by sensitive Enterobacteriaceae bacteria, Pseudomonas aeruginosa, Acinetobacter, upper urinary tract and complicated urinary tract infection, respiratory tract infection, and biliary tract infection , abdominal infection, pelvic infection, and skin and soft tissue infection. The combination of piperacillin sodium / sulbactam sodium and piperacillin sodium / tazobactam sodium has good stability, and shows strong antibacterial activity against common clinical enzyme-producing bacte...

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