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Cefmetazole sodium liposome freeze-dried preparation and preparation method

A technology of cefmetazole sodium lipid and freeze-dried preparations, which is applied in the field of cefmetazole sodium liposome freeze-dried preparations and preparations, can solve the problem of temperature, light, and humidity instability, which can easily cause quality changes and increase the safety of clinical medication Sex and other issues, to achieve a good stability effect

Inactive Publication Date: 2012-07-04
张宏民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because this product is unstable to temperature, light, and humidity, it is prone to precipitation during use, and it is easy to cause quality changes during production, transportation, and use, which increases the safety of clinical medication.

Method used

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  • Cefmetazole sodium liposome freeze-dried preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Cefmetazole Sodium 1.0 weight unit

[0026] Sodium chloride 1.5 weight units

[0027] Egg yolk lecithin, distearic acid lecithin, soybean lecithin 1:1 mix 2.5 weight units

[0028] Mannitol 1.0 weight unit

[0029] Sodium hydrogen phosphate 0.5~3.0 weight units

[0030] Weigh the prescription amount of cefmetazole sodium, sodium chloride, and mannitol, mix and dissolve in water, stir evenly, and set aside; weigh an appropriate amount of sodium hydrogen phosphate to prepare a 10% buffer salt solution, and mix the prescription amount of egg yolk lecithin and double hard Fatty acid lecithin and soybean lecithin are dispersed and dissolved, dried under reduced pressure to form a blank film material, added to the above aqueous solution, and ultrasonically processed to a cefmetazole sodium liposome suspension with the desired particle size and uniformity; Containing, filling, and vacuum freeze-drying to obtain cefmetazole sodium liposome freeze-dried preparation.

Embodiment 2

[0032] Cefmetazole Sodium 1.0 weight unit

[0033] Sodium chloride 1.5 weight units

[0034] Lecithin Dipalmitate 5.0 weight units

[0035] Mannitol 1.0 weight unit

[0036] Calcium hydrogen phosphate 0.5~3.0 weight units

[0037] Weigh the prescription amount of Cefmetazole Sodium, Sodium Chloride, and Mannitol, mix them and dissolve in water, stir evenly, and set aside; Weigh an appropriate amount of calcium hydrogen phosphate to prepare a 10% buffer salt solution, and mix the prescription amount of Lecithin with double palmitate Disperse and dissolve, dry under reduced pressure to form a blank film material, add it to the above aqueous solution, and ultrasonically treat it to the required particle size and uniformity of the cefmetazole sodium liposome suspension; constant volume, filling, and vacuum freezing After drying, the lyophilized preparation of cefmetazole sodium liposome is obtained.

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Abstract

The invention provides a cefmetazole sodium liposome freeze-dried preparation and a preparation method. The method comprises the following steps of: adding cefmetazole sodium, a stabilizing agent and an excipient into a blank membrane material made of a liposome carrier, performing ultrasonic processing, fixing volume, filling, and freeze drying to obtain the cefmetazole sodium liposome freeze-dried preparation. The cefmetazole sodium liposome freeze-dried preparation prepared by the method overcomes the defect of formulations appear on the market, has improved stability and is safer in clinical application of medicaments.

Description

Technical field: [0001] The present invention relates to a method for treating infections caused by Staphylococcus aureus, Escherichia coli, Pneumoniae bacillus, Proteus, Morganella morganii, Providencia, Peptostreptococcus, and Bacteroides A cephalosporin drug, in particular, relates to a cefmetazole sodium liposome freeze-dried preparation and a preparation method. Background technique: [0002] Cefmetazole sodium, chemical name: (6R, 7R)-7-[2-[(cyanomethyl)sulfur]acetamido]-7-methoxy-3-[(1-methyl-1H-tetra (Azol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. [0003] Chemical Structure: [0004] [0005] Molecular formula: C 15 H 16 N 7 NaO 5 S 3 Molecular weight: 493.52 [0006] Cefmetazole sodium is the second-generation cephalosporin, a semi-synthetic antimicrobial drug for parenteral applications. It was first introduced into the clinic in Japan, and a large number of animal and clinical studies have also been conducted in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K9/127A61K31/546A61K47/24A61P31/04
Inventor 张宏民
Owner 张宏民
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