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Cefmetazole-containing pharmaceutical composition

A technology of cefmetazole sodium and its composition, which is applied in the field of new pharmaceutical preparation compositions, can solve the problems of unsatisfactory dissolution speed, increase of dissolution speed, and stability problems, and achieve rapid dissolution, ensure stability, and durability Good effect

Active Publication Date: 2012-10-17
哈药集团股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, cefmetazole sodium is mainly in the form of powder injection, but due to the influence of various factors, the dissolution rate of existing products is not satisfactory. Since it does not contain preservatives, it must be used immediately after dissolution
Therefore, it is beneficial for patients to develop a convenient freeze-dried injection of cefmetazole sodium to increase the dissolution rate and avoid the stability problems caused by long-term storage.

Method used

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  • Cefmetazole-containing pharmaceutical composition

Examples

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Effect test

Embodiment 1

[0052] Cefmetazole sodium 500g;

[0053] Mannitol 150g;

[0054] Calcium EDTA 2g;

[0055] Vitamin C 1.5g,

[0056] 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4,

[0057] Add water for injection to 4000ml

[0058]

[0059] 1000 bottles

[0060] Preparation: First mix 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packaged, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium hydrogen citrate 13g,...

Embodiment 2

[0062] Cefmetazole sodium 1000g;

[0063] Mannitol 200g;

[0064] Calcium EDTA 3g;

[0065] Vitamin C 2g,

[0066] Disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4 2000ml

[0067] Add water for injection to 4L

[0068]

[0069] 1000 bottles

[0070]Preparation: First mix 1000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packed, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium hydrogen citrate 13g, trisodiu...

Embodiment 3

[0072] Cefmetazole sodium 500g;

[0073] Mannitol 100g;

[0074] Calcium EDTA 1g;

[0075] Vitamin C 1g,

[0076] Disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4 2000ml

[0077] Add water for injection to 4L

[0078]

[0079] 1000 bottles

[0080] Preparation: First mix 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packaged, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium h...

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Abstract

The invention relates to a novel pharmaceutic preparation composition, especially to an injection preparation of cefmetazole. The injection preparation comprises the following components: cefmetazole, mannitol, EDTA-Ca, vitamin C, sodium hydrogen citrate, a trisodium citrate buffer solution and water for injection.

Description

Technical field: [0001] The invention relates to a new pharmaceutical preparation composition, in particular to an injection preparation of cefmetazole sodium, its prescription, application and preparation method. Background technique: [0002] Cefmetazole sodium (Cefmetazole), also known as cyanazol-methoxycephalosporin, cefmetazol, vanguard metabolite, vanguard dense forest, cefmetazole sodium, cefmethoxazole, is a second-generation cephalosporin. The broad-spectrum β-lactamases produced by the negative bacilli had better stability. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Shigella, Salmonella and other negative bacilli have good sensitivity to this product. Staphylococcus aureus, Group A hemolytic streptococcus, and Brahamella catarrh are highly sensitive to this product. It is used for respiratory system infection, biliary tract infection, urinary system infection, obstetrics and gynecology bacterial infection, skin and soft tissue infection and other...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/546A61K47/26A61K47/18A61K47/22A61K47/12A61P31/04
Inventor 孙志嘉杨新春王喜军陈桂芹
Owner 哈药集团股份有限公司
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