The invention relates to a large-thickness Q500GJCD high-strength steel plate for a building structure, and a manufacturing method thereof. The chemical components of the steel plate comprise, by mass, 0.12%-0.17% of C, 0.20%-0.50% of Si, 1.10%-1.60% of Mn, no more than 0.015% of P, no more than 0.005% of S, 0.10%-0.30% of Cr, no more than 0.30% of Mo, 0.10%-0.30% of Ni, no more than 0.30% of Cu, 0.02%-0.04% of Al, 0.020%-0.060% of Nb, 0.01%-0.02% of Ti, no more than 0.20% of V+Nb+Ti, no more than 0.006% of N and unavoidable impurity elements, and the carbon equivalent is no more than 0.46%. The technological process comprises the steps of hot metal pretreatment, converter steel making, LF refining, RH furnace refining, blank casting of a continuous casting machine, blank heating, control rolling of a rolling mill, and Acc cooling and finishing. The steel plate for the building structure, provided by the application, has the advantages of uniform performance, excellent comprehensive performance, short production cycle and low production cost.