The invention discloses an ammonium chloride neutralization reaction kettle which comprises a reaction kettle body, wherein a plurality of U-shaped grooves are uniformly distributed in the outer wall of the reaction kettle body, a layer of shell is arranged at the outer part of the reaction kettle body, a stirring device is arranged inside the reaction kettle body, a cooling liquid inlet is formed in one side at the upper part of the shell, a feed opening is formed in the other side at the upper part of the shell, a cooling liquid outlet is formed in one side at the lower part of the shell, a discharge opening is formed in the other side at the lower part of the shell, a gap is reserved between the reaction kettle body and the shell and fully filled with a fiber ball filler; the reaction kettle is arranged to have a double layer structure, so that the cooling liquid flow rate can be controlled, the temperature of the reaction kettle can be regulated, neutralization reaction of ammonium chloride can be facilitated, and a stirring shaft is arranged to have a hollow structure, therefore the reaction kettle can be cleaned more conveniently and safely, and at the same time, as specifically prepared titanium alloy is taken as the material of the reaction kettle, the reaction kettle has not only a good mechanical property, but also excellent corrosion resistance and heat resistance, the service cycle of the reaction kettle is prolonged, and long-term cost input of manufacturing enterprises can also be reduced.