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Pharmaceutical composition and application thereof in preparing medicine for treating multidrug resistance of tumors

A composition and drug technology, applied in the field of biomedicine, to achieve the effect of reversing drug resistance, solving drug resistance, and reversing drug resistance well

Active Publication Date: 2018-06-15
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although dacarbazine, gemcitabine and Opdivo can be used to treat cancer, drug resistance will also appear as the drug time increases, and once drug resistance occurs, the effect of the drug will be significantly reduced. Therefore, it is urgent to develop new drugs to efficiently reverse drug resistance

Method used

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  • Pharmaceutical composition and application thereof in preparing medicine for treating multidrug resistance of tumors
  • Pharmaceutical composition and application thereof in preparing medicine for treating multidrug resistance of tumors
  • Pharmaceutical composition and application thereof in preparing medicine for treating multidrug resistance of tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1 Oral preparation prescription of pharmaceutical composition of the present invention

[0052] 1. Prescription one

[0053] Chlorogenic acid 1000g, coumaroylquinic acid 1g.

[0054] Preparation method: aseptically weigh chlorogenic acid and coumaroylquinic acid according to the prescription, mix them evenly, and aseptically pack them into powders.

[0055] 2, prescription two

[0056] Chlorogenic acid 1000g, coumaroylquinic acid 5g, filler 500g, binder 5g.

[0057] Preparation method: Weigh chlorogenic acid, coumaroylquinic acid, filler and binder according to the prescription, granulate, granulate, and divide into granules.

[0058] 3, prescription three

[0059] Chlorogenic acid 1000g, coumaroylquinic acid 1g, filler 500g, binder 5g, lubricant 3g.

[0060]Preparation method: weighing chlorogenic acid, coumaroylquinic acid, filler and binder according to the prescription, granulating, sizing, adding lubricant, pressing into tablets to obtain tablets. ...

Embodiment 2

[0062] Embodiment 2 The prescription of the pharmaceutical composition injection preparation of the present invention

[0063] 1. Prescription one

[0064] Chlorogenic acid 1000g, coumaroylquinic acid 1g.

[0065] Preparation method (1): aseptically weigh chlorogenic acid and coumaroylquinic acid according to the prescription, mix them uniformly, and aseptically pack them into powder injections.

[0066] Preparation method (2): according to the prescription, chlorogenic acid and coumaroylquinic acid are weighed, dissolved in water for injection, sterilized by filtration, and freeze-dried to obtain freeze-dried powder for injection.

[0067] 2, prescription two

[0068] Chlorogenic acid 1000g, coumaroylquinic acid 1g, stent agent 2667g, antioxidant 67g.

[0069] Preparation method: weigh chlorogenic acid, coumaroylquinic acid, stent agent and antioxidant according to the prescription, dissolve in water for injection, filter sterilize, freeze-dry, and obtain freeze-dried powd...

experiment example 1

[0072] Experimental Example 1 The composition of the present invention and its monomeric compounds reverse the resistance of human melanoma to the chemical drug dacarbazine in vitro 1. Materials

[0073] 1.1 Test drugs

[0074] Test Drug 1: Chlorogenic Acid

[0075] Test Drug 2: Coumaroylquinic Acid

[0076] Test Drug 3: Chlorogenic Acid and Coumaroylquinic Acid Composition (100:0.01)

[0077] Test Drug 4: Chlorogenic Acid and Coumaroylquinic Acid Composition (100:0.05)

[0078] Test Drug 5: Chlorogenic Acid and Coumaroylquinic Acid Composition (100:0.1)

[0079] Test drug 6: Chlorogenic acid and coumaroylquinic acid composition (100:0.5)

[0080] Positive drug: dacarbazine (5-(3,3-dimethyl-1-triazenyl)-4-amidoimidazole citrate).

[0081] 1.2 Cell lines

[0082] The melanoma cell line A375 is a routinely cultured strain in the laboratory. It is passaged before use, and the cells with good growth state and growth in logarithmic phase are used for future use.

[0083] 2. ...

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Abstract

The invention discloses a pharmaceutical composition and an application thereof in preparing a medicine for treating multidrug resistance of tumors and belongs to the field of biomedicines. The pharmaceutical composition is prepared from chlorogenic acid and tonka-bean quinic acid and can be used for preparing a reversal agent and a PD-1 / PD-L1 inhibitor for the multidrug resistance of the tumors.The pharmaceutical composition and the application disclosed by the invention have the beneficial effects that by combined use of the chlorogenic acid and the tonka-bean quinic acid, the synergistic interaction can be exerted, the drug-resistance reversal action on the tumor cell strain generating multidrug resistance for chemotherapeutic drugs and immunotherapeutic drugs is good, the expression of PD-1 / PD-L1 of tissues of transplanted tumors of mice with drug-resistant B16 melanoma and drug-resistant Lewis lung cancer can be effectively suppressed, and a role in proliferating CD4+T and CD8+Tcells of the mice with the drug-resistant B16 melanoma and the drug-resistant Lewis lung cancer can be effectively played.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a pharmaceutical composition and its use in preparing a medicine for treating tumor multidrug resistance. Background technique [0002] Cancer is a major public health problem that needs to be solved urgently in China and all regions of the world. On average, millions of people are diagnosed with cancer every year, including more than 200 types of cancer. Currently, cancer is the main cause of death. one of the diseases. However, due to the poor selectivity of anti-cancer drugs, single drug therapy has the defects of large toxic and side effects or poor therapeutic effect, so the research of a new generation of low-toxic and efficient drugs has become a top priority in the treatment of malignant tumors. [0003] The chemical name of dacarbazine is: 5-(3,3-dimethyl-1-triazenyl)-4-amidoimidazole citrate. Alias, aminodimine. This product can be decomposed in the body to rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P35/00
CPCA61K31/216A61K2300/00A61K9/0019A61K9/19A61K9/2018A61K31/655A61K31/7068A61K47/26A61P35/00C07K16/2818
Inventor 张洁陈晓光杨华蓉黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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