Application of interleukin 21 (IL-21) in preparation of anti-hepatitis B virus (HBV) medicine preparations

A hepatitis B virus, IL-21 technology, applied in the fields of genetic engineering and biomedicine, can solve the problems of large adverse reactions, inability to clear cccDNA of liver cell nucleus, and low patient response rate, so as to improve the conversion rate and reduce hepatitis B. Viral DNA load, effect of durable protection
CN108324930AInactive Publication Date: 2018-07-27FUDAN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUDAN UNIV
Publication Date
2018-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the fields of genetic engineering and biomedicines and relates to a novel medicinal application of interleukin 21 (IL-21), and particularly relates to an application of the IL-21 in preparation of an anti-HBV preparation. Tests prove that by using the IL-21 for intervening in a HBV chronically infected mouse model, conversion rate of hepatitis B surface antigen (HBsAg) andhepatitis B e antigen (HBeAg) can be significantly increased, and meanwhile, DNA carrying quantity of HBV in serum is significantly reduced. The IL-21 can be used as a medicine precursor for developing a novel anti-hepatitis B virus medicine.
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Description

technical field

[0001] The invention belongs to the field of genetic engineering and biomedicine, and relates to the new medicinal use of interleukin-21 (Interleukin-21, IL-21), in particular to the use of interleukin-21 in the preparation of anti-hepatitis B virus (Hepatitis B Virus, HBV) pharmaceutical preparations use. Background technique

[0002] The prior art discloses that hepatitis B caused by hepatitis B virus (HBV) infection is mainly hepatic inflammatory lesions, and may be complicated by multiple organ damage. Studies have shown that after HBV infection becomes chronic hepatitis B (CHB), it can also lead to liver fibrosis, cirrhosis, primary hepatocellular carcinoma (HCC) and liver failure, eventually leading to death. According to statistics, with the maturity of HBV vaccine and the promotion of vaccination, the rate of new HBV infection has dropped significantly, but there are still about 350 million chronic carriers of HBV in the world, and about 1 million pa...

Claims

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