Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of forsythiaside A in preparing hepatitis B therapeutic drug

A technology of forsythiaside and hepatitis B, applied in the field of medicine, can solve the problem that the antiviral pharmacological activity of forsythiaside A is few and other problems

Active Publication Date: 2010-06-30
SHANDONG NEWTIME PHARMA
View PDF5 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few studies on the antiviral pharmacological activity of forsythiaside A in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of forsythiaside A in preparing hepatitis B therapeutic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1 (forsythiaside A anti-hepatitis B virus test in vitro)

[0011] 1. Purpose of the test:

[0012] To observe the pharmacodynamic effect of forsythiaside A against hepatitis B virus.

[0013] 2. Test materials:

[0014] Test drug: Forsythiaside A freeze-dried powder injection, provided by Shanghai Yusen New Drug Development Co., Ltd., batch number: 060909.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of forsythiaside A in preparing a hepatitis B therapeutic drug. An anti-hepatitis B virus test in vitro of the forsythiaside A shows that the forsythiaside A can effectively inhibit hepatitis B antigen and hepatitis B viruses, which is characterized by the following aspects: using a HepG2.2.2.15 cell model, TC50 cytotoxicity of the forsythiaside A in vitro is equal to 739mu g / mL; IC50 of inhabitation on S antigen is equal to 149.4mu g / mL; IC50 of inhabitation on e antigen is equal to 139.6mu g / mL; and IC50 of inhabitation on a cell HBV-DNA is equal to 56.3mu g / mL.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new medicine application of forsythiaside A. Background technique [0002] Forsythoside A (Forsythoside A) is an active ingredient extracted from the plant Forsythia (Fructus Forsythiae) of Oleaceae. In the past, forsythiaside was used as an index to investigate the extraction process of forsythia. In recent years, with the deepening of research on the active ingredients of forsythia, it was found that forsythin has no antibacterial activity, and forsythiaside A has the antibacterial activity. Its structural formula is as follows: [0003] [0004] In recent years, it has been reported in the literature that forsythiaside has a good antibacterial effect: For example, Wang Hongjun et al. reported that forsythiaside has antibacterial effects on Staphylococcus aureus, Streptococcus dysgalactia, and nongalactiae in vitro and in vivo that cause mastitis in dairy cows...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P1/16A61P31/12
CPCA61K31/7028A61P1/16A61P31/12A61P31/20
Inventor 玄振玉
Owner SHANDONG NEWTIME PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products