159results about How to "High molar extinction coefficient" patented technology

The invention discloses a new green synthesizing process for a ketocoumaran compound. The synthesizing process comprises the following steps: in the absence of a solvent, performing condensation reaction of a mandelic acid compound and hydroquinol under the action of a little amount of acid catalyst to obtain a full condensed intermediate, wherein the acid catalyst is selected from one of 10 to 37 percent concentrated hydrochloric acid, 60 to 98 percent concentrated sulfuric acid, fuming sulfuric acid, 80 to 98 percent phosphoric acid, polyphosphoric acid, p-toluenesulfonic acid, trifloromethanesulfonic acid, benzoic acid, ammonium acetate, ammonium chloride, KF, TiC14, NiCl2, CuSO4, Cu(OAc)2, ZnCl2, AlCl3, Fe(NO3)3, FeCl3 and SnCl2; and performing oxidation reaction of full condensed intermediate under the action of an oxidant to obtain a final product ketocoumaran compound. The synthesizing process of the invention is simple, and has low energy consumption and little environmental pollution.

The invention provides a pure organic dye containing conjugated units of different heterocyclic rings and derivatives thereof and application thereof in a dye-sensitized solar cell. The pure organic dye belongs to molecules of a D-phi-A structure. Segments of a donor, a phi conjugated system and a receptor are properly adjusted and controlled respectively to form the pure organic dye with wide spectral response and high molar extinction coefficient. The absorption spectrum of the pure organic dye is over 570 nanometers already close to the absorption of ruthenium dye; and when the pure organic dye is applied to the dye-sensitized solar cell, the photoelectric conversion efficiency of more than 10 percent is obtained, so the dye is the current most efficient and stable pure organic dye.

Belong to synthesis of functional dyes and their application as fluorescent dyes in the field of fine chemicals, the invention relates to synthesis and application of an indole hemicyanine dye. The compound is formed by condensation of an indole quaternary ammonium salt and corresponding aldehyde, and has the advantages of large molar extinction coefficient, good light stability, and easy synthesis, etc. According to different substituent groups and anions, the molecule involved in the invention can have pH probe properties, solid-state fluorescence properties and the performance to combine with biomacromolecules. When serving as a pH probe, the compound can adjust probe pKa according to different substituent groups, and can be used for bi-color living cell imaging; when serving as a solid-state emission dye, the compound can adjust its solid-state emission wavelength according to different substituent groups and anions; and when serving as a biomolecular probe, the compound has good response to biological molecules and live cell membrane permeability, and can be used for cell staining. Due to its long absorption and emission wavelength, the compound can avoid the interference of biomass autofluorescence, and also reduce the damage of excitation light on cells or biological tissues.

The invention discloses heterocycle alkaline-washable carboxylic acid ethyl ester type disperse dye. The molecular structure of the disperse dye comprises carboxylic acid ethyl ester groups, and the structural general formula of the carboxylic acid ethyl ester groups is D-COOC2H5, wherein the D refers to a color body with a heterocycle azo structure. The invention further provides a preparation method of the heterocycle alkaline-washable carboxylic acid ethyl ester type disperse dye, existing cyanophoric disperse dye is selected as a raw material, and an alcoholysis method is applied to preparation of the heterocycle alkaline-washable carboxylic acid ethyl ester type disperse dye. The disperse dye has good dyeing property, and has high dye-uptake rate and color fastness when being applied to Dacron dyeing; during post-treatment of PET (polyethylene terephthalate) fiber dyeing, acid dye containing water soluble groups and harmfulless ethyl alcohol are generated only through alkaline solution treatment of fibers to achieve ester group hydrolysis, and the obtained acid dye can be recycled through acidification and the like.

The invention relates to a (methylbenzotriazole) phenol benzoate compound. The compound has a structure shown in the Formula I. The (methylbenzotriazole) phenol benzoate compound designed and synthesized has excellent ultraviolet absorption performance due to a relatively wide ultraviolet absorption wave band and a relatively large molar extinction coefficient. Besides, the (methylbenzotriazole) phenol benzoate compound designed and synthesized by the invention has relatively large molecular weight, thus being not easy to migrate and lose during the processing process of a high molecular polymer (served as an additive). In the Formula I, R1 is -OH, R2 and R3 are respectively selected from one of H or an electron-attracting group.

The invention relates to design synthesis and application of a near-infrared two-window fluorescence probe based on Aza-BODIPY, and belongs to the field of organic fluorescence probes. A near-infraredtwo-area dyestuff (NIR-II, 1000-1700nm) has a long emission wavelength and less light scattering and tissue autofluorescence interference so as to obtain better resolution ratio and imaging depth inbioimaging. An Aza-BODIPY fluorescent dye has a longer absorption emission wavelength, a narrower peak width at half height and a larger molar extinction coefficient, and is widely applied to the fields such as photodynamic therapy. The structural formula of the near-infrared two-window fluorescence probe designed and synthesized by the invention is as shown in the figure (I). According to the probe, electron-donating group julolidine is introduced onto the classic Aza-BODIPY structure, and the molecular rigidity is improved. The probe has excellent light stability and a capacity of resistingdisturbance. The probe successfully realizes near-infrared two-window imaging during the mice imaging experiment.

The present invention relates to a nano immunomagnetic bead-near infrared fluorescence notation labeling method-based mycobacterium tuberculosis lipoarabinomannan (LMA) detection kit, a near-infrared fluorescence dye is used for labeling of a monoclonal antibody targeted to LAM, and nano magnetic bead surface is coated with a polyclonal antibody targeted to LAM, by use of the principle of double antibody sandwich method, a conjugate and free substances are magnetically separated, a a portable high sensitivity and low noise excitation fluorescence detector is used to detect the fluorescence intensity of the magnetic conjugate so as to detect the LAM content of a sample to be tested. The detection kit is applicable to the LAM detection in clinical and pathological specimens, and has the characteristics of being rapid, sensitive, anti-stray fluorescence interference, and long in emission fluorescence save time.

Provided is an image recording material capable of being directly recorded by various kinds of lasers, excellent in alkali-developability by alkaline developer and capable of forming an image which is good in curability by exposure. The image recording material is characterized by including on a support: an image recording layer containing a binder polymer (A); a compound (B) having a polymerizable unsaturated group, and a polymerization initiator (C); and a layer containing an organic ionic polymer (a) formed of a non-metallic element and an inorganic layered compound (b) that are layered in this order. It is preferable that the image recording layer further contains a dye (D) having an absorption maximum in a region of 300 to 1,200 nm, and it is preferable that the binder polymer (A) is a polymer having an alkali-soluble group.

The invention discloses a fluorescence probe based on BODIPY type singlet oxygen. The fluorescence probe has the characteristics of high sensitivity, high selectivity and fast response in a neutral environment for detection of singlet oxygen. The fluorescence probe has no fluorescence, fluorescence is obviously enhanced after response with the singlet oxygen, the fluorescence intensity and the concentration of the singlet oxygen have good linear relation, the fluorescence probe can be used for quantitative detection, and other active oxygen substances do not interfere detection. The prepared fluorescence probe has classic BODIPY spectral characteristic, can detect mercury ions in chemical samples, biological samples or medical samples on the basis of fluorescence enhancement or chromaticity enhancement, and is suitable for fluorescence imaging.

The invention belongs to the technical field of biological materials, and particularly relates to a near-infrared window II emission type fluorescent dye as well as a preparation method and application thereof. The near-infrared fluorescent dye provided by the invention has the advantages of being large in molar extinction coefficient, long in absorption and emission wavelength and wide in adjustable range, and therefore the dye can be applied to deep-tissue multi-channel imaging, fluorescent encoding microspheres and the like; and in addition, the dye is not liable to generate solvatochromismin a polar solvent, has better stability in water compared with an existing common near-infrared window II heptamethine cyanine fluorescent dye and has very good chemical stability within a relatively large acid-base range.

The invention discloses a red temporary water-soluble disperse dye and a manufacturing method and use thereof. The structure formula of the dye is shown below. The chromatographic peak of the dye disclosed by the invention is wide, the dyeing exhaust property of the dye is better, the raffinate is almost colorless, the molar extinction coefficient of the dye is high, and the color of the dye is bright; the yield of the dye is close to a theoretical value, and waste water treatment is convenient; and color fastness to light and color fastness to washing are greatly improved than before. The dye can be used for preparing ink for ink-jet printers. When the ink is used, the dye separated out on printing paper does not dissolve again, nor disperse upon contact with water, and thus, the application range of the ink-jet printers is expanded.

The invention discloses a triphenyldioxinimide diploid compound and a preparation method thereof, and belongs to the technical field of organic synthesis. A triphenyldioxinmide diploid is synthesizedand obtained by adopting monobromotriphenyldioxinimide and reacting with a monoboric acid aromatic hydrocarbon, a monopinacol borate aromatic hydrocarbon or a monotributyltin aromatic hydrocarbon under the action of a catalyst and an alkali through a C-C coupling method. Through the introduction of an aliphatic side chain of the triphenyldioxazine imide diploid, the dissoluvability of the triphenyldioxinimide diploid is effectively ameliorated; a conjugately bridged diploid structure can generate spatial warping to inhibit molecular aggregation and the triphenyldioxinimide diploid compound canshow excellent photoelectric performance when being applied to an organic photoelectric device.

The invention provides a taurine substituted bodipy fluorescent compound, and further provides a preparation method of the taurine substituted bodipy fluorescent compound. The method comprises the following steps: reacting 8-(4-position substituted phenyl)-3, 5-diiodo-1, 2, 6, 7-tetra-substituted bodipy and 1,2-disubstituted taurine under the conditions of an additive, a catalyst and a solvent toobtain 8-(4-position substituted phenyl) 3-iodo-5-(2-ethanesulfonic acid) amine)-1,2,6,7-tetra-substituted bodipy and 8-(4-position substituted phenyl) 3,5-bis((2-ethanesulfonic acid) amine)-1,2,6,7-tetra-substituted bodipy. According to the taurine substituted bodipy fluorescent compound, by a cheap metal catalyzed direct C-X/N-H activating method, taurine with biological activity is introducedat a 3,5 activated site of star fluorescent molecule bodipy, and therefore, a novel fluorescent molecule framework is formed.

The invention belongs to the technical field of disperse dyes and particularly relates to a polylactic acid fiber dyeing azo structured lactate type disperse dye and a preparation method and dyeing process thereof. The polylactic acid fiber dyeing azo structured lactate type disperse dye is prepared by taking a hydroxyl group-containing disperse dye as the raw material for reflux reaction with lactic acid. The polylactic acid fiber dyeing azo structured lactate type disperse dye introduces lactate groups which are similar in structure to fiber and high in polarity to improve the compatibilitywith polylactic acid fiber and increase the dyeing rate; meanwhile, hydroxyl of the lactate groups can increase the boiling point of the polylactic acid fiber dyeing azo structured lactate type disperse dye and help form intermolecular hydrogen bonds to improve the color fastness to sublimation of the polylactic acid fiber dyeing azo structured lactate type disperse dye. Therefore, the polylacticacid fiber dyeing azo structured lactate type disperse dye is bright in color, high in color intensity and fastness and good in dyeing effects.

The invention relates to phthalocyanine-azo double-chromophore activated dye having a high fixation rate and a preparing method and application thereof. The method includes copper phthalocyanine chlorosulfonation to prepare a phthalocyanine turquoise blue base, a first time of condensation, a second time of condensation, diazotization and a coupling reaction to obtain the activated dye having a high fixation rate. The dye is suitable for pattern printing for cotton, artificial cotton, linen, regenerated fibers and textiles thereof, and has a high fixation rate, bright color, excellent improving performance, good washable fastness, good color fastness to rubbing and a good application prospect.

The invention relates to the field of photo-functional materials, in particular to a red light excited fluorescent dye. The red light excited fluorescent dye has a structure shown as the formula (I) in the description. The red light excited fluorescent dye has quite wide excitation spectrum, is good in photostability and high in sensitivity, realizes trace detection, can be used in different application fields such as cell imaging, fluorescence probes, laser dyes, fluorescence sensors and the like, and shows good practicability. According to the preparation method, raw material cost is low, nopollution is produced, the process is simple, and yield is high; the prepared fluorescent dye is novel in structure, good in performance and suitable for being widely applied in the fields of biology, environment and the like.

The invention relates to near infrared quinoline type heptamethine cyanine dye and a preparation method thereof and belongs to the field of chemical organic dye synthesis. Synthetic near infrared dyehas the advantages of excellent optical performance such as in a near infrared region 2, large compound Stokes shift, high photostability, few synthesis step and convenience for purification. The mostobvious characteristics of the dye include high absorptivity in the near infrared zone 2, excellent penetrability to environment and biological tissue and high quantum yield in an organic solvent like dichloromethane. The dye can be used in the field of biomolecular marking and fluorescence imaging. A probe preparation method is simple and easy to implement, low in cost, good in economic benefitand suitable for industrial production.

The invention discloses a near-infrared two-zone squaric acid quinoline dye and a preparation method thereof, and belongs to the field of organic dye synthesis. The prepared squaric acid quinoline dyeis of a symmetrical chemical structure, looks like a brown to black solid, has a melting point of 200 to 400 DEG C. The R alkyl group is a C1-C8 alkyl chain, and changing the length of the R alkyl chain does not affect the wavelength of fluorescence and can meet different use requirements, so that the dye is applied more widely. The near-infrared two-zone squaric acid quinoline dye prepared by the preparation method has a fluorescence emission wavelength of 900 to 1,100 nm, a high molar extinction coefficient, good light stability, can effectively avoid biological background fluorescence interference, has the advantages of high fluorescence quantum yield, short synthesis steps and the like, has excellent penetrability to the environment and biological tissues, and provides a good application prospect for biomolecular markers, solar cells, fluorescent imaging and the like.

The invention relates to a method for detecting aflatoxin M1. According to the method, aflatoxin B1 marked by enzyme is taken as a competitive antigen, and on the basis of a dynamic light scattering technology, the aflatoxin M1 is detected through a direct competitive enzyme linked immunoassay analysis method. The method reduces the affinity between the competitive antigen and a monoclonal antibody of the aflatoxin M1, and the problem is solved that the sensitivity is reduced due to the fact that the competitive antigen is not easily competed by s target competitive antigen; the detection of an output signal is performed by means of the dynamic light scattering method, compared with a traditional direct competitive enzyme linked immunoassay analysis method, the detection sensitivity can beimproved, and the trace detection of the aflatoxin M1 can be achieved.