New raw material for extracting fructus schizandrae total lignans and preparation technique and use

A technology of total lignans and preparation process, applied in the field of medicine, can solve the problems of rising prices, reduction of Schisandra chinensis resources, plucking of green leaves, etc., and achieve the effect of alleviating the shortage of supply

Inactive Publication Date: 2008-07-09
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the market demand for Schisandra chinensis is very large, which is far from meeting the requirements of domestic and foreign markets. Extinct vine harvesting and destruction of wild resources have occurred, and the phenomenon of plundering greens has generally occurred in some areas, which has caused Schisandra chinensis resources to be affected to varying degrees. Destruction, leading to the reduction of available resources of Schisandra chinensis, the decline of quality, and the rising price

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Schisandra schisandra leaves 2Kg, pulverized, refluxed with water to extract twice, each time kept in a slightly boiling state for 1.5 hours, filtered, and the combined filtrate was discarded. After the residue was dried, 14L of 80% ethanol was added, extracted under reflux for 3 times, each time for 2 hours, filtered, and the filtrates were combined and concentrated under reduced pressure to obtain 610 g of a concentrated solution with a density of 0.93. Enriched with a macroporous adsorption resin column, gradient eluted with water, 60% ethanol, and 90% ethanol respectively, collected the 90% ethanol eluate, recovered ethanol under reduced pressure, enriched with a macroporous adsorption resin column again, and used water, 75% ethanol respectively. % ethanol, eluting with 90% ethanol, collecting the 90% ethanol eluate, recovering ethanol under reduced pressure to obtain 15 g of extract. The total lignan content is 60%.

Embodiment 2

[0017] Schisandra schisandra leaves 2Kg, pulverized, refluxed with water to extract twice, each time kept in a slightly boiling state for 1.5 hours, filtered, and the combined filtrate was discarded. After the residue was dried, 14L of 80% ethanol was added, heated and refluxed for 3 times, each time for 2 hours, filtered, the filtrates were combined, and the ethanol was recovered under reduced pressure to obtain 130 g of dry extract. Reflux extraction with petroleum ether for 3 times, combine the extracts, concentrate under reduced pressure to a small volume of 10ml, enrich through silica gel column chromatography, elute with petroleum ether: ethyl acetate (20:1), then use petroleum ether: acetic acid Ethyl ester (2:1) was eluted, and petroleum ether: ethyl acetate (2:1) eluate was collected and concentrated under reduced pressure to obtain 10 g of extract. The total lignan content is 65%.

Embodiment 3

[0019] Schisandra schisandra fruit stem (stalk) 2Kg, pulverized, added water and refluxed for extraction twice, each time kept in a slightly boiling state for 1.5 hours, filtered, and the combined filtrate was discarded. After the residue was dried, 12L of 90% ethanol was added, heated and refluxed for 3 times for 2 hours each time, filtered, and the filtrates were combined and concentrated under reduced pressure to obtain 650 g of a concentrated solution with a density of 0.91. Enriched with a macroporous adsorption resin column, gradient eluted with water, 70% ethanol, and 90% ethanol respectively, collected 90% ethanol eluate, recovered ethanol under reduced pressure to obtain 20 g of extract. The total lignan content is 63%.

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Abstract

The present invention pertains to the art of medical technology and discloses a novel raw material for Schisandraceae lignans extracted substance and a preparation method thereof. The process takes Chinese medicine Schisandraceae stem (fruit stalk) and Schisandraceae leave as the raw material and adopts one or a plurality of solvent extraction method, resin absorption method, positive-phase column chromatography, reverse-phase column chromatography, etc. after grinding, so as to prepare the extracted substance with 30 to 95 percent of total lignans content. The preparation method has simple process, stable content and good repeatability. The extracted substance can be used as medicine or health food instead of Schisandraceae lignans extracted substance, which makes full use of Schisandraceae resource and releases the short supply of Schisandraceae fruit.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new raw material of Schisandra chinensis total lignan extract and a preparation process thereof. The extract obtained according to the preparation process has a total content of lignans in 30-95%. For the prevention and treatment of hepatitis. Background technique [0002] The fat-soluble active ingredients of Schisandra chinensis are mainly lignans. Its pharmacological effects involve various aspects such as digestive system, cardiovascular system, central nervous system, reproductive system, anti-oxidation and anti-aging (Chinese herbal medicine, volume 28, phase 2, February 2005). [0003] Schisandra chinensis (Turcz.) Baill., Schisandra chinensis (Turcz.) Baill., Schisandra sphenanthera Rehd.et Wils. and other plants of the genus Schisandra. . [0004] Foreign scholars applied high performance liquid chromatography to detect the CO content of Schisandra cotyledon 2 The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P1/16A23L1/30C07B63/00A61K127/00A61K131/00
Inventor 殷军胡荻刘雪寒刘志惠
Owner SHENYANG PHARMA UNIVERSITY
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