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49 results about "Oxygen tension" patented technology
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The Oxygen tension is the amount of oxygen that is dissolved in the liquid portion of blood (plasma). It can be measured accurately by taking a sample of arterial blood and putting it into an analyzer that gives you a measurement in mm of mercury.
Biosensor having improved hematocrit and oxygen biases
ActiveUS7501053B2Accurate responseDesensitizationImmobilised enzymesBioreactor/fermenter combinationsQuinoneManganese
A biosensor that utilizes a mediator, i.e., an isomer of phenanthroline quinone, 1,10-phenanthroline-5,6-dione, and a metal ion, such as manganese, with an enzyme dependent upon NAD(P)+, such as, for example, glucose dehydrogenase, for improving the hematocrit bias and oxygen bias of biosensors. The electrodes of the biosensors employing this mediator and a metal ion provide an accurate clinical response over a hematocrit range that ranges from about 20% to about 70% and over an oxygen tension range that ranges from about 1 kPa to about 20 kPa.
Owner:ABBOTT DIABETES CARE INC
Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids
ActiveUS20180177458A1Avoid problemsUseful in detectionMedical devicesCatheterEngineeringPleural spaces
Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids are described which are capable of sensing physiologic data based on sensors incorporated into a catheter adapted to reside in any of a urinary tract, gastrointestinal tract, rectal location, pre-peritoneal, pleural space or other body cavity. The devices aid emptying of the bladder, measure urine output and various urine parameters such as oxygen tension, urine conductance and urine specific gravity, monitor renal function, analyze urine parameters, including urine content, including the presence of infection, and track and / or control fluid administration.
Owner:POTRERO MEDICAL
Process for extracting vanadium form oxygen tension pickle liquor of high ferro vanadium-containing stone coal
InactiveCN101289703AHigh recovery rateReduce consumptionProcess efficiency improvementKeroseneSolvent
The invention provides a method for extracting vanadium from ferri containing vanadium bone coal oxygen pressure acid leach solution. The invention relates to a method for extracting vanadium from ferri containing vanadium bone coal oxygen pressure acid leach solution, belonging to the metallurgic-chemical technical field. The method is characterized in that according to the content of iron impurity (Fe<3+>) in leach solution and the percentage needed for completion of the reaction, inorganic salt reducing agents are added, which reduce Fe<3+> in the leach solution into Fe<2+>, and the leach solution is cooled to the room temperature, and the pH value of the leach solution is adjusted by NaOH solution, and the synergistic extraction of vanadium is made by mixing kerosene solvent of P204 and TBP. The method has the advantages of simple technical process, little reagent consumption, low disposal cost, high recovery rate of vanadium and high purity, etc., and is widely applied to the process of extracting vanadium from stone coal acid leach solution.
Owner:KUNMING UNIV OF SCI & TECH
Methods of generating functional human tissue
Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and / or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and / or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Modulation of mitochondrial oxygen consumption for therapeutic purposes
InactiveUS20070212360A1Increased blood vessel formationReduced activityBiocideAntibody ingredientsPhysiologyTherapeutic intent
The HIF-1 transcription factor drives gene expression changes in hypoxia. While HIF-1 stimulates glycolysis, it also actively represses mitochondrial function and oxygen consumption by inducing pyruvate dehydrogenase kinase 1 (PDK1). PDK1 phosphorylates and inhibits pyruvate dehydrogenase from converting pyruvate to acetyl-CoA to fuel the mitochondrial TCA cycle. This causes a drop in mitochondrial oxygen utilization and results in a relative increase in intracellular oxygen tension.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
System for estimating state of critically ill patient in obstetrical department
InactiveCN101554322AImprove the level of treatmentReduce mortalitySurgeryDiagnostic recording/measuringNervous systemCritically ill
The invention discloses a system for estimating the state of a critically ill patient in an obstetrical department, which comprises an input end, an output end and a data processing module. Firstly, measured heart rate, blood pressure, body temperature, breathing rate, pH, blood HCO-3 concentration, oxygen partial pressure, alveolar arterial blood oxygen tension difference, potassium ion concentration, hematokrit, white cell count, platelet count, fibrinogen, glutamic-oxaloacetic transaminase, albumin, bilirubin, creatinine, blood glucose concentration and nervous system grading data are input the system through the input end; the data processing module evaluates a death risk factor; and at last, the output end directly reflects the result of the patient and the expert suggestion. The invention can not only accurately evaluate the critical degree of the state of the patient and predict the death risk, but also can provide quantitative indexes for changing to a three-class hospital, and is beneficial to improve the treatment level of the critical state of the obstetrical department and lower the death rate of pregnant and lying-in women and perinatal infants.
Owner:陈敦金 +1
Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids
Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids are described which are capable of sensing physiologic data based on sensors incorporated into a catheter adapted to reside in any of a urinary tract, gastrointestinal tract, rectal location, pre-peritoneal, pleural space or other body cavity. The devices aid emptying of the bladder, measure urine output and various urine parameters such as oxygen tension, urine conductance and urine specific gravity, monitor renal function, analyze urine parameters, including urine content, including the presence of infection, and track and / or control fluid administration.
Owner:POTRERO MEDICAL
In vitro fertilisation
InactiveUS20050239040A1Quality improvementIncrease probabilityBioreactor/fermenter combinationsBiological substance pretreatmentsMammalCoendou speratus
The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension. Stem cells are produced from the multicellular pre-embryo.
Owner:REGION HOVEDSTADEN VHERLEV HOSPITAL
Bioreactor for cell growth and associated methods
InactiveUS20090155908A1Promote cell growthPromote growthBioreactor/fermenter combinationsBiological substance pretreatmentsThree dimensional matrixHydrostatic pressure
Apparatuses, systems, and methods are provided for growing and maintaining cells. A three-dimensional matrix, such as a hydrogel material, is seeded with cells and placed in a bioreactor having two compartments. The matrix is supported between the two compartments by first and second porous materials, which engage opposing surfaces of the matrix. A first media stream having certain properties is propagated through the first compartment, where it contacts one surface of the matrix via the first porous material. A second media stream having different properties is propagated through the second compartment such that it contacts the opposite surface of the matrix via the second porous material. Through migration of each stream at least partially into the matrix, various controlled gradients may be established within the matrix, encouraging growth of the cells. Such gradients include osmotic pressure, oscillating osmotic pressure, hydrostatic pressure, oxygen tension, and / or nutrient gradients.
Owner:HALBERSTADT CRAIG DR
Bioreactor Device, and Method and System for Fabricating Tissues in the Bioreactor Device
InactiveUS20090215104A1Increase sample sizeBioreactor/fermenter combinationsBiological substance pretreatmentsFluid shearHydrostatic pressure
A bioreactor device, and a method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 μL) of local medium volume but sample sizes of about 100 μL or greater. The bioreactor device includes a bioreactor chamber for containing a sample, where sample growth in response to mechanical, electrical, and biofactor stimulation is monitored through one or more optical ports. Embedded sensors are provided for measuring fluid pressure, pH, temperature, and oxygen tension. The bioreactor device can receive different types of mechanical loadings, including fluid shear, hydrostatic pressure, matrix compression, and clinorotation.
Owner:UNITED STATES OF AMERICA
Compositions of stem cells and stem cell factors and methods for their use and manufacture
Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture.
Owner:STEMEDICA CELL TECH
Multimode neurobiophysiology probe
InactiveUS20120035583A1Convenient treatmentSave livesHead electrodesDiagnostics using spectroscopyDiseaseClosed loop
Deep Brain Stimulation (DBS) is taking off and will be part of the main treatment for brain diseases such as movement disorders, epilepsy, psychiatric diseases and many others. There is a need for more sophisticated devices that can do more in one penetration, not just stimulate. Once there is a probe in the brain, it is used for multiple passive measurements, without harming the brain further. It provides better understanding the brain and real time closed loop improved treatment. An apparatus and method are disclosed, which allow simultaneous monitoring of multiple parameters inside the human brain, such as: pH, temperature, pressure, seizure activity (EEG), degree of metabolism, oxygen tension in the brain, degree of excitotoxicity and others. The ability to measure those parameters during treatment and stimulation procedures makes the difference between success and failure of the patient.
Owner:SEPKUTY JEHUDA PETER
Parthenogenic activation of human oocytes for the production of human embryonic stem cells
Methods of producing human stem cells by parthenogenetically activating human oocytes by manipulation of oxygen tension, including manipulation of Ca2+ under high 02 tension using anionophore and contacting oocytes with serine threonine kinase inhibitors (DMAP) under low 02 tension, isolating inner cell masses (ICMs) from the activated oocytes, and culturing the cells of the isolated ICMs under high 02 tension. Moreover, methods are described for the production of stems cells from activated oocytes in the absence of non-human animal products, including the use of human feeder cells / products for culturing ICM / stem cells. Stem cells produced by the disclosed methods are also described.
Owner:INT STEM CELL CORP
Device and method for processing waste water with high COD concentration through catalytic wet oxidation
ActiveCN103043774AAchieve recyclingWell mixedWater/sewage treatment by oxidationChemical oxygen demandReaction temperature
The invention relates to the technical field of processing of organic waste water in environmental conservation, in particular to a device and a method for processing waste water with high COD (Chemical Oxygen Demand) concentration through catalytic wet oxidation. The method is characterized in that transition metal salt is taken as reaction catalyst, an air and liquid mixer is adopted in a reaction system so as to realize the cyclic utilization of oxidizing gases, reaction is performed under the temperature of 110 to 150 DEG C and the oxygen tension of 0.25 to 1 MPa, the reaction time is 1.5 to 2.5 hours, under the standard state, the volume ratio of the oxygen and the waste water is (10 to 15):1, and the dosage of the catalyst ranges from 0.006-0.06 mol / L as per the ratio of moles of the transition metal ions and the waste water volume. The transition metal salt is one of copper sulfate, diiron trisulfate, ferrous sulfate, manganese sulfate and cobalt acetate. Compared with the prior art, the invention has the advantages of mild reaction conditions, low reaction temperature, lowered gas tension, and more than 90% of removal rate of COD in waste water.
Owner:SICHUAN YUECHENG ENVIRONMENTAL PROTECTION & ENERGY SAVING TECH CO LTD
Selective cell therapy for the treatment of renal failure
Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein the cells have been expanded in vitro. The kidney cells preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells express EPO in vivo in an oxygen tension-dependent manner.
Owner:WAKE FOREST UNIV HEALTH SCI INC
Microfluidic array platform for simultaneous cell culture under oxygen tensions
The present invention relates to a microfluidic array platform comprising a substrate and two layers between which one membrane is sandwiched, wherein a plurality of cell culture wells are constructed in the top layer and one or more microfluidic channels for oxygen scavenging reactions or / and oxygen generating reactions to control the oxygen tensions are constructed in the bottom player. The microfluidic array platform is capable of simultaneously performing cell culture under different oxygen tensions and compatible with existing cell incubators and high-throughput instruments for cost-effective setup and straightforward operation.
Owner:ACAD SINIC
Bioreactor device, and method and system for fabricating tissues in the bioreactor device
InactiveUS8709793B2Bioreactor/fermenter combinationsBiological substance pretreatmentsFluid shearEngineering
Owner:UNITED STATES OF AMERICA
Silicone-peroxide compositions for long-term, controlled oxygen release
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The polymer support can exhibit an oxygen tension value of at least 40 mmHg for a period of 14 days. The weight ratio of biocompatible polymeric support to solid peroxide particles can range from 1:1 to 99:1. Also disclosed is a method of using the composite to deliver oxygen to cells in both in vivo and in vitro environments.
Owner:UNIV OF MIAMI +1
System and method for measuring oxygenation parameters
Systems and methods are described for calculating, in real-time, various oxygenation parameters including total oxygen transport (DO 2), mixed venous blood oxygen tension (RO 2) and mixed venous blood oxyhemoglobin saturation (SvO 2) in a patient. The system preferably uses a computer (140), an arterial pressure line (160) and a blood chemistry monitor (150) to assist a physician in accurately determining when to give a patient a blood transfusion or otherwise alter the clinical management of the patient.
Owner:联合药品公司
Low oxygen tension enhances endothelial fate of human pluripotent stem cells
ActiveUS20170009204A1Lower oxygen partial pressureInduces endothelial commitmentCulture processArtificial cell constructsInduced pluripotent stem cellEndothelial NOS
Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (EVC) derivation induces endothelial commitment and maturation of pluripotent stem cells. Inhibition of reactive oxygen species generation during the early stages of differentiation abrogates the endothelial inductive effects of the low oxygen environments. Methods of generating various types of cells from pluripotent stem cells (PSCs) are described, as well as compositions and methods of use thereof. In particular, generation of EVCs, bicellular vascular populations, early endothelial cells (ECs) and pericytes via culture in a low oxygen environment is described.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Method For Supplying Oxygenated Water To Promote Internal Healing
InactiveUS20080262413A1ElectrotherapyInorganic active ingredientsHydrogen peroxide breakdownDecomposition
Owner:LADIZINSKY DANIEL A
Methods and compositions to modulate the gut microbiota and to manage weight
ActiveUS20180147167A1Good effectIncreasing oxygen tensionPeptide/protein ingredientsMetabolism disorderIntestinal microorganismsLarge intestine
Methods of weight management for a subject are provided. Generally the methods comprising: administering an effective amount to the small intestine and / or large intestine of the subject of at least one agent that increases oxygen tension and / or redox potential and / or pH in the colon of the subject to thereby manage the weight of the subject. Also provided are compositions comprising at least one agent that increases oxygen tension and / or redox potential and / or pH, wherein the composition is formulated for delivery of an effective amount of the at least one agent to the small intestine and / or large intestine of a subject following oral ad ministration of the composition to the subject.
Owner:XENO BIOSCI INC
Secondary metabolite congener distribution modulation
The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distribution.
Owner:KOSAN BIOSCI
Methods and compositions to modulate the gut microbiota and to manage weight
ActiveUS10945974B2Increased riskImprove the quality of lifePeptide/protein ingredientsMetabolism disorderBiotechnologyMicroorganism
Methods of weight management for a subject are provided. Generally the methods comprising: administering an effective amount to the small intestine and / or large intestine of the subject of at least one agent that increases oxygen tension and / or redox potential and / or pH in the colon of the subject to thereby manage the weight of the subject. Also provided are compositions comprising at least one agent that increases oxygen tension and / or redox potential and / or pH, wherein the composition is formulated for delivery of an effective amount of the at least one agent to the small intestine and / or large intestine of a subject following oral ad ministration of the composition to the subject.
Owner:XENO BIOSCI INC
Stem cells and stem cell factors for inhibiting the progression of alzheimer's disease
PendingUS20160143950A1Increase speedHigh yieldBiocideMicrobiological testing/measurementDiseaseOxygen tension
Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. The invention also contemplates the use of such stem cells in the treatment of neurodegenerative disorders including Alzheimer's disease and stroke.
Owner:STEMEDICA INT
In vitro fertilisation
InactiveUS7547541B2Quality improvementIncrease probabilityBioreactor/fermenter combinationsBiological substance pretreatmentsMammalBiology
Owner:REGION HOVEDSTADEN VHERLEV HOSPITAL
In vitro fertilisation
InactiveUS20090281370A1Quality improvementIncrease probabilityBioreactor/fermenter combinationsBiological substance pretreatmentsMammalBiology
The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension Stem cells are produced from the multicellular pre-embryo.
Owner:REGION HOVEDSTADEN VHERLEV HOSPITAL
Plaster for treating ulcer of lower limbs
InactiveCN105535335AQuick resultsShort course of treatmentHeavy metal active ingredientsAnthropod material medical ingredientsBarbed Skullcap HerbSide effect
The invention belongs to the technical field of traditional Chinese medicines and particularly provides a plaster for treating ulcer of lower limbs. The plaster for treating the ulcer of the lower limbs is prepared from angelica roots, pangolins, honeysuckles, a barbed skullcap herb, radix angelicae sinensis, radix rehmanniae, garden balsam stems, radix sileris, gallnuts, fructus forsythiae, stiff silkworms, peach kernels, cassia twigs, Chinese honeylocust spine, radix cyathulae, folium artemisiae argyi, long pepper, radix bupleuri, frankincense, myrrh, calomel, dragon's blood, camphor, borneol, musk, minium and sesame oil. The plaster follows the theory of 'removing necrotic tissues to promote tissue regeneration and removing pus to promote tissue regeneration' of Chinese medicine, enables the Chinese herbal medicines to be externally coated on affected parts, makes the medicine effects act on the local parts, conditions the oxygen tension of the affected parts and angiogenesis, facilitates dissolution of necrotic tissues and fibrous protein, promotes release of multiple growth factors and further achieves the purposes of relieving pain and accelerating wound healing, and clinical trials show that the plaster is remarkable in curative effect, economic, practical, free of side effects and worthy of clinical popularization and application.
Owner:许诚章
Silicone-peroxide compositions for long-term, controlled oxygen release
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The polymer support can exhibit an oxygen tension value of at least 40 mmHg for a period of 14 days. The weight ratio of biocompatible polymeric support to solid peroxide particles can range from 1:1 to 99:1. Also disclosed is a method of using the composite to deliver oxygen to cells in both in vivo and in vitro environments.
Owner:UNIV OF MIAMI +1
Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity
InactiveUS20140286910A1Increase speedHigh yieldBiocideNervous system cellsOxygen tensionStem cell culture
Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. The invention also contemplates the use of such stem cells in the treatment of neurodegenerative disorders including Alzheimer's disease and stroke.
Owner:STEMEDICA INT +1
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