The invention relates to a biodegradable nanometer
fiber diaphragm applied to
neurosurgery indirect vascular bypass. The biodegradable nanometer
fiber diaphragm can be produced through the following steps: dissolving a
biodegradable polymer material in a polar and volatile
organic solvent, carrying out electrostatic
spinning to produce a diaphragm composed of ultrafine fibers with the nano-scale diameters; and loading growth factors for promoting
brain tissue blood vessel regeneration and / or promoting nerve regeneration to the diaphragm through a layer and layer self-assembling technology, and
drying the factor growth supported diaphragm. The biodegradable nanometer
fiber diaphragm has the advantages of no
toxicity, no generation of harmful substances after
in vivo degradation, and good
biocompatibility. The biodegradable nanometer fiber diaphragm can avoid
growth factor inactivation caused by organic solvents,
strong acids, strong alkalis and high temperature, and an assembled polyelectrode can guarantee the good activity of the
growth factor supported on the diaphragm. The biodegradable nanometer fiber diaphragm can realize long-term
controlled release of VEGF, NGF and other growth factors in the brain
blood vessel obstruction position in order to induce
blood vessel regeneration and nerve regeneration of the
brain tissue blood vessel obstruction position.